Osman Asghar Mirza
Associate Professor
Biopharmaceuticals
Jagtvej 162, 2100 København Ø
- 2007
- Published
Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains
Tanabe, M., Mirza, Osman Asghar, Bertrand, T., Atkins, H. S., Titball, R. W., Iwata, S., Brown, K. A. & Byrne, B., 2007, In: Acta Crystallographica. Section D: Biological Crystallography. 63, 11, p. 1185-1193Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter
Weyand, S., Shimamura, T., Yajima, S., Suzuki, S., Mirza, Osman Asghar, Krusong, K., Carpenter, E. P., Rutherford, N. G., Hadden, J. M., O'Reilly, J., Ma, P., Saidijam, M., Patching, S. G., Hope, R. J., Norbertczak, H. T., Roach, P. C. J., Iwata, S., Henderson, P. J. F. & Cameron, A. D., 2008, In: Science. 322, 5902, p. 709-713Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency
Beich-Frandsen, M., Pickering, Darryl S, Mirza, Osman Asghar, Johansen, Tommy Nørskov, Greenwood, J., Vestergaard, Bente, Schousboe, Arne, Gajhede, Michael, Liljefors, T. & Kastrup, Jette Sandholm Jensen, 2008, In: Journal of Medicinal Chemistry. 51, 5, p. 1459-63Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit
Paës, G., Skov, L. K., O'Donohue, M. J., Rémond, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2008, In: Biochemistry. 47, 28, p. 7441-7451Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides
Ernst, H. A., Pham, A., Hald, H., Kastrup, Jette Sandholm Jensen, Rahman, M. & Mirza, Osman Asghar, 2009, In: Biochemical and Biophysical Research Communications. 389, 1, p. 112-116Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove
Champion, E., Remaud-Simeon, M., Skov, L. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2009, In: Acta Crystallographica. Section D: Biological Crystallography. 65, 12, p. 1309-1314Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus
Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Mirza, Osman Asghar, 2010, In: Protein Expression and Purification. 71, 2, p. 179-183Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Strukturer af membranproteiner: nøglen til rationelt lægemiddeldesign
Hald, H. & Mirza, Osman Asghar, Dec 2010, In: Lægemiddelforskning. 2010, p. 13-15Research output: Contribution to journal › Journal article › Communication
- 2012
- Published
Probing the putative active site of YjdL: an unusual proton-coupled oligopeptide transporter from E. coli
Jensen, J. M., Ismat, F., Szakonyi, G., Rahman, M. & Mirza, Osman Asghar, 2012, In: P L o S One. 7, 10, p. e47780Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional investigation of conserved membrane-embedded glutamate residues in the proton-coupled peptide transporter YjdL
Jensen, J. M., Ernst, H. A., Wang, X., Hald, H., Ditta, A. C., Ismat, F., Rahman, M. & Mirza, Osman Asghar, Mar 2012, In: Protein and Peptide Letters. 19, 3, p. 282-287Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the proton-coupled oligopeptide transporter YjdL
Jensen, J. M., Simonsen, F. C., Mastali, A., Hald, H., Lillebro, I., Diness, Frederik, Olsen, L. & Mirza, Osman Asghar, Nov 2012, In: Peptides. 38, 1, p. 89-93 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology
Skov, L. K., Pizzut-Serin, S., Remaud-Simeon, M., Ernst, H. A., Gajhede, Michael & Mirza, Osman Asghar, Sep 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, Pt 9, p. 973-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
New insights into the substrate specificities of proton-coupled oligopeptide transporters from E. coli by a pH sensitive assay
Prabhala, B. K., Aduri, N. G., Jensen, J. M., Ernst, H. A., Iram, N., Rahman, M. & Mirza, Osman Asghar, 16 Jan 2014, In: FEBS Letters. 588, 4, p. 560-565Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL
Jensen, J. M., Aduri, N. G., Prabhala, B. K., Jahnsen, R., Franzyk, Henrik & Mirza, Osman Asghar, 24 Sep 2014, In: International Journal of Biochemistry & Cell Biology. 55, p. 311-17 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
A functional EXXEK motif is essential for proton coupling and active glucosinolate transport by NPF2.11
Jørgensen, M. E., Olsen, C. E., Geiger, D., Mirza, Osman Asghar, Halkier, Barbara Ann & Nour-Eldin, Hussam Hassan, 2015, In: Plant and Cell Physiology. 56, 12, p. 2340-2350 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of putative multidrug resistance transporters of the major facilitator-superfamily expressed in Salmonella Typhi
Shaheen, A., Ismat, F., Iqbal, M., Haque, A., De Zorzi, R., Mirza, Osman Asghar, Walz, T. & Rahman, M., 2015, In: Journal of Infection and Chemotherapy. 21, 5, p. 357–362 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of synthetic peptides by mass spectrometry
Prabhala, B. K., Mirza, Osman Asghar, Højrup, P. & Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibiodies. Springer, p. 77-82Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Investigation of the substrate specificity of the proton coupled peptide transporter PepTSo from Shewanella oneidensis
Prabhala, B. K., Aduri, N. G., Hald, H. & Mirza, Osman Asghar, 2015, In: International Journal of Peptide Research and Therapeutics. 15, 21, p. 1-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Salt-bridge Swapping in the EXXERFXYY Motif of Proton Coupled Oligopeptide Transporters
Aduri, N. G., Prabhala, B. K., Ernst, H. A., Jørgensen, Flemming Steen, Olsen, L. & Mirza, Osman Asghar, 2015, In: The Journal of Biological Chemistry. 290, 50, p. 29931-29940 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Monitoring mammary tumor progression and effect of tamoxifen treatment in MMTV-PymT using MRI and magnetic resonance spectroscopy with hyperpolarized [1-(13) C]pyruvate
Asghar Butt, S., Søgaard, L. V., Ardenkjaer-Larsen, J. H., Lauritzen, M. H., Engelholm, L. H., Paulson, Olaf B., Mirza, Osman Asghar, Holck, S., Magnusson, P. & Akeson, P., 16 Jan 2015, In: Magnetic Resonance in Medicine. 73, p. 51-58 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Activity of the Human Rhinovirus 3C Protease Studied in Various Buffers, Additives and Detergents Solutions for Recombinant Protein Production
Ullah, R., Shah, M. A., Tufail, S., Ismat, F., Imran, M., Iqbal, M., Mirza, Osman Asghar & Rhaman, M., 2016, In: PloS one. 11, 4, 13 p., e0153436.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptide Selectivity of the Proton-Coupled Oligopeptide Transporter from Neisseria meningitidis
Sharma, N., Aduri, N. G., Iqbal, A., Prabhala, B. K. & Mirza, Osman Asghar, 2016, In: Journal of Molecular Microbiology and Biotechnology. 26, 5, p. 312-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Origin and evolution of transporter substrate specificity within the NPF family: [with Correction]
Jørgensen, M. E., Xu, Deyang, Crocoll, C., Ernst, H. A., Ramírez, D., Motawie, Mohammed Saddik, Olsen, C. E., Mirza, Osman Asghar, Nour-Eldin, Hussam Hassan & Halkier, Barbara Ann, 2017, In: eLife. 6, 30 p., e19466.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression, purification and characterization of the human MTA2-RBBP7 complex
Brasen, C., Dorosz, J., Wiuf, A., Boesen, T., Mirza, Osman Asghar & Gajhede, Michael, 4 Feb 2017, In: Biochimica et biophysica acta. 1865, 5, p. 531-538 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR
Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In: Research in Microbiology. 168, 5, p. 443-449Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302772
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Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
275
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Origin and evolution of transporter substrate specificity within the NPF family: [with Correction]
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
243
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Activity of the Human Rhinovirus 3C Protease Studied in Various Buffers, Additives and Detergents Solutions for Recombinant Protein Production
Research output: Contribution to journal › Journal article › Research › peer-review
Published