Petrine Wellendorph

Petrine Wellendorph

Professor

ORCID: 0000-0002-5455-8013

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  1. Published

    Boganmeldelse: Bogsalonen Kubulus Alumni

    Wellendorph, Petrine, 2012

    Research output: Other contribution › Net publication - Internet publication › Communication

  2. Published

    Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain

    Wellendorph, Petrine, Høg, S., Greenwood, J. R., de Lichtenberg, A., Nielsen, Birgitte, Frølund, Bente, Brehm, L., Clausen, Rasmus Prætorius & Bräuner, Hans, Oct 2005, In: Journal of Pharmacology and Experimental Therapeutics. 315, 1, p. 346-51

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    The emerging role of promiscuous 7TM receptors as chemosensors for food intake

    Wellendorph, Petrine, Johansen, L. D. & Bräuner, Hans, 1 Jan 2010, Incretins and insulin secretion. Litwack, G. (ed.). Amsterdam: Elsevier Editora, Vol. 84. p. 151-184 (Vitamins & hormones, Vol. 84).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  4. Published

    gamma-Aminobutyric Acid and Glycine Neurotransmitter Transporters

    Wellendorph, Petrine, Jacobsen, Julie, Skovgaard-Petersen, J., Jurik, A., Vogensen, S. B., Ecker, G., Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2017, Transporters As Drug Targets.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  5. Published

    Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids

    Wellendorph, Petrine, Hansen, K. B., Balsgaard, A., Greenwood, J. R., Egebjerg, J. & Bräuner, Hans, Mar 2005, In: Molecular Pharmacology. 67, 3, p. 589-97

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Characterization of GPRC6A: a 7TM receptor activated by L-alpha-amino acids and positively modulated by divalent cations

    Wellendorph, Petrine, Hansen, K. B., Christiansen, B., Burhenne, N., Balsgaard, A., Greenwood, J. R., Walter, B., Schmale, H., Egebjerg, J. & Bräuner, Hans, 2008, In: Fundamental and Clinical Pharmacology. Suppl. 2, p. 19

    Research output: Contribution to journal › Conference abstract in journal › Research

  7. Published

    A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues

    Wellendorph, Petrine, Jaroszewski, J. W., Hansen, S. H. & Franzyk, Henrik, 2003, In: European Journal of Medicinal Chemistry. 38, 1, p. 117-22 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Molecular basis for amino acid sensing by family C G-protein-coupled receptors

    Wellendorph, Petrine & Bräuner, Hans, 2009, In: British Journal of Pharmacology. 156, 6, p. 869-884

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    TREATMENT OF CNS DISORDERS WITH SLEEP DISTURBANCES

    Wellendorph, Petrine, Kornum, Birgitte Rahbek & Frølund, Bente, 2020, Patent No. WO2020259787 , 30 Dec 2020, Priority date 28 Jun 2019, Priority No. DK2019PA70415 20190628

    Research output: Patent

  10. Published

    Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor

    Wellendorph, Petrine, Goodman, M. W., Burstein, E. S., Nash, N. R., Brann, M. R. & Weiner, D. M., Jun 2002, In: Neuropharmacology. 42, 7, p. 929-40 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain

    Wellendorph, Petrine, Høg, S., Skonberg, C. & Bräuner, Hans, 2009, In: Fundamental and Clinical Pharmacology. 23, 2, p. 207-213 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients

    Wellendorph, Petrine, Johansen, L. D. & Bräuner, Hans, 2009, In: Molecular Pharmacology. 76, 3, p. 453-465

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor

    Wellendorph, Petrine & Bräuner, Hans, 23 Jun 2004, In: Gene. 335, p. 37-46

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions

    Wellendorph, Petrine, Johansen, L. D., Jensen, Anders A., Casanova, E., Gassmann, M., Deprez, P., Clément-Lacroix, P., Bettler, B. & Bräuner, Hans, 2009, In: Journal of Molecular Endocrinology. 42, 3, p. 215-223

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Novel radioiodinated γ-hydroxybutyric acid analogues for radiolabeling and photolinking of high-affinity γ-hydroxybutyric acid binding sites

    Wellendorph, Petrine, Høg, S., Sabbatini, P., Pedersen, M. H. F., Martiny, L., Knudsen, Gitte Moos, Frølund, Bente, Clausen, Rasmus Prætorius & Bräuner, Hans, 2010, In: Journal of Pharmacology and Experimental Therapeutics. 335, 2, p. 458-464

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Hvorfor er det fedt at være forsker: Mysteriet som drivkraft: Blogindlæg

    Wellendorph, Petrine, 2012

    Research output: Other contribution › Net publication - Internet publication › Communication

  17. Published

    The rat GPRC6A: cloning and characterization

    Wellendorph, Petrine, Burhenne, N., Christiansen, B., Walter, B., Schmale, H. & Bräuner, Hans, 15 Jul 2007, In: Gene. 396, 2, p. 257-267 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Selective mGAT2 (BGT-1) GABA Uptake Inhibitor: Design, synthesis and pharmacological characterization

    Vogensen, S. B., Jørgensen, L., Madsen, K. K., Borkar, N. N., Wellendorph, Petrine, Skovgaard-Petersen, J., Schousboe, Arne, White, H. S., Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 11 Feb 2013, In: Journal of Medicinal Chemistry. 56, 5, p. 2160-2164 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites

    Vogensen, S. B., Marek, A., Bay, T., Wellendorph, Petrine, Kehler, J., Bundgaard, C., Frølund, Bente, Pedersen, M. H. F. & Clausen, Rasmus Prætorius, 2013, In: Journal of Medicinal Chemistry. 56, 20, p. 8201–8205

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Målrettet fisketur i hjernen giver ny viden om Fantasy’s virkningssted

    Villumsen, I. S., Vogensen, S. B., Frølund, Bente, Clausen, Rasmus Prætorius & Wellendorph, Petrine, 2011, In: Lægemiddelforskning. 2011, p. 26-28

    Research output: Contribution to journal › Journal article › Communication

  21. Published

    Fra forældreløs ligand til receptor kernefamilie

    Villumsen, I. S. & Wellendorph, Petrine, 2012, Årsskrift 2011-2012 Det Unge Akademi. København: Det Kongelige Danske Videnskabernes Selskab, Vol. 2012. p. 28-31

    Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Communication

  22. Published

    Målrettet fisketur i hjernen giver ny viden om Fantasys virkningssted

    Villumsen, I. S., Vogensen, S. B., Frølund, Bente, Clausen, Rasmus Prætorius & Wellendorph, Petrine, Dec 2011, In: Lægemiddelforskning. 2011, p. 26-28

    Research output: Contribution to journal › Journal article › Communication

  23. Published

    Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes

    Villumsen, I. S., Wellendorph, Petrine & Smart, T. G., 2015, In: BMC Neuroscience. 16, 8, p. 1-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Exploring the NCS-382 Scaffold for CaMKII alpha Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKII alpha Hub Domain

    Tian, Yongsong, Shehata, M. A., Gauger, Stine Juul, Veronesi, C., Hamborg, L., Thiesen, L., Bruus-Jensen, J., Royssen, J. S., Leurs, U., Larsen, A. S. G., Krall, J., Solbak, Sara Marie Øie, Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 22, p. 15066–15084

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain

    Tian, Yongsong, Shehata, M. A., Gauger, Stine Juul, Ng, C. K. L., Solbak, Sara Marie Øie, Thiesen, L., Bruus-Jensen, J., Krall, J., Bundgaard, C., Gibson, K. M., Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 9, p. 6656-6676

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4

    Thiesen, L., Belew, Zeinu Mussa, Griem-Krey, Nane, Pedersen, Stine Helene Falsig, Crocoll, C., Nour-Eldin, Hussam Hassan & Wellendorph, Petrine, 15 Feb 2020, In: European Journal of Pharmaceutical Sciences. 143, p. 1-9 105203.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    In vitro and in vivo evidence for active brain uptake of the GHB analogue HOCPCA by the monocarboxylate transporter subtype 1

    Thiesen, L., Kehler, J., Clausen, Rasmus Prætorius, Frølund, Bente, Bundgaard, C. & Wellendorph, Petrine, 2015, In: Journal of Pharmacology and Experimental Therapeutics. 354, 2, p. 166-174 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Lack of evidence for synaptic high-affinity γ-hydroxybutyric acid (GHB) transport in rat brain synaptosomes and 11 Na+ -dependent SLC neurotransmitter transporters

    Thiesen, L., Frølund, Bente & Wellendorph, Petrine, Apr 2019, In: Journal of Neurochemistry. 149, 2, p. 195-210 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids

    Smajilovic, S., Wellendorph, Petrine & Bräuner, Hans, 2014, In: Current Pharmaceutical Design. 20, p. 2693-702 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release

    Smajilovic, S., Clemmensen, Christoffer, Johansen, L. D., Wellendorph, Petrine, Holst, Jens Juul, Thams, P. G., Ogo, E. & Bräuner, Hans, 2013, In: Amino Acids. 44, 2, p. 383-390 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    GABA transport cycle: beyond a GAT feeling

    Shahsavar, Azadeh & Wellendorph, Petrine, 2023, In: Nature Structural and Molecular Biology. 30, p. pages863–865

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  32. Published

    Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs

    Schousboe, Arne, Wellendorph, Petrine, Frølund, Bente, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 283-296 14 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  33. Published

    Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites

    Sabbatini, P., Wellendorph, Petrine, Høg, S., Pedersen, M. H. F., Bräuner, Hans, Martiny, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2010, In: Journal of Medicinal Chemistry. 53, 17, p. 6506-6510

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors

    Rostrup, F., Falk-petersen, C. B., Harpsøe, Kasper, Buchleithner, S., Conforti, I., Jung, S., Gloriam, David E., Schirmeister, T., Wellendorph, Petrine & Frølund, Bente, 22 Apr 2021, In: Journal of Medicinal Chemistry. 64, 8, p. 4730-4743 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Functional modulation of a pH-sensitive ion channel by a transporter family

    Poulsen, Mette Homann, Xue, F., Maurya, S. R., Kickinger, Stefanie, Usher, Samuel George, Wellendorph, Petrine, Lundby, Alicia & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 249a

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  36. Published

    Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model

    Petersen, Louise Piilgaard, Rose, Laura, Justinussen, Jessica, Hviid, C. G., Lemcke, René, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2023, In: Sleep. 46, 9, 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Radioiododestannyllation of novel GHB neuroreceptor ligands

    Pedersen, M. H. F., Høg, S., Wellendorph, Petrine & Martiny, L., 2010, In: Journal of Labelled Compounds and Radiopharmaceuticals. 5-6, p. 318-320

    Research output: Contribution to journal › Conference article › Research › peer-review

  38. Published

    (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction

    Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 357-366

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Development of a medium throughput whole-cell microtiter plate Thr286 autophosphorylation assay for CaMKIIα using ELISA

    Palmelund, L. B., van Woerden, G. M., Bräuner, Hans & Wellendorph, Petrine, 2022, In: Journal of Pharmacological and Toxicological Methods. 118, 8 p., 107226.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers

    Olsen, Christian Adam, Mellor, I. R., Wellendorph, Petrine, Usherwood, P. N. R., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2006, In: ChemMedChem. 1, 3, p. 303-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Synthesis of gamma-Aminobutyric Acid (GABA) Analogues Conformationally Restricted by Bicyclo[3.1.0]hexane/hexene or [4.1.0]Heptane/heptene Backbones as Potent Betaine/GABA Transporter Inhibitors

    Mitsui, K., Lie, M. E. K., Saito, N., Fujiwara, K., Watanabe, M., Wellendorph, Petrine & Shuto, S., 2022, In: Organic Letters. 24, 23, p. 4151-4154

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

    Lolli, M. L., Hansen, S. L., Rolando, B., Nielsen, Birgitte, Wellendorph, Petrine, Madsen, K., Larsen, O. M., Kristiansen, Uffe, Fruttero, R., Gasco, A. & Johansen, Tommy Nørskov, 2006, In: J. Med. Chem.. 49, p. 4442-4446 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Transmembrane transporter proteins: Capturing transport in motion

    Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  44. Published

    GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep

    Lie, M. E. K., Falk-Petersen, C. B., Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia

    Lie, M. E., Gowing, E. K., Clausen, Rasmus Prætorius, Wellendorph, Petrine & Clarkson, A. N., 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 1, p. 166-173

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice

    Lie, M. E., Gowing, E. K., Johansen, N. B., Dalby, N. O., Thiesen, L., Wellendorph, Petrine & Clarkson, A. N., 1 Jan 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 1, p. 74-88 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

    Lie, M. E. K., Kickinger, S., Skovgaard-Petersen, J., Ecker, G. F., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Wellendorph, Petrine, 2020, In: Neurochemical Research. 45, p. 1551–1565

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke

    Lie, M. E. K., Al-Khawaja, A., Damgaard, M., Haugaard, A. S., Schousboe, Arne, Clarkson, A. N. & Wellendorph, Petrine, 2017, Advances in Neurobiology. Vol. 16. p. 137-167 31 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  49. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Synthesis and Pharmacological Evaluation of [C-11]4-Methoxy-N-[2-(thiophen-2-yl) imidazo[1,2-a] pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the delta-Subunit-Containing gamma-Aminobutyric Acid Type A Receptors

    L'Estrade, E. T., Hansen, H. D., Falk-Petersen, C., Haugaard, A., Griem-Krey, Nane, Jung, S., Lueddens, H., Schirmeister, T., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, May 2019, In: ACS Omega. 4, 5, p. 8846-8851

    Research output: Contribution to journal › Journal article › Research › peer-review

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