Petrine Wellendorph

Petrine Wellendorph

Professor

ORCID: 0000-0002-5455-8013

Publication year:
All
1 - 50 out of 109Page size: 50
Sort by: Title
  1. Published

    (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction

    Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 357-366

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes

    Karim, N., Gavande, N., Wellendorph, Petrine, Johnston, G. A. R., Hanrahan, J. R. & Chebib, M., 15 Dec 2011, In: Biochemical Pharmacology. 82, 12, p. 1971-1983

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    A CLASS OF SMALL-MOLECULE COMPOUNDS AND THEIR PRODRUGS FOR INTERVENTION WITH CAMK2A, AND THEIR USE IN ACUTE BRAIN INJURIES AND CENTRAL HYPERSOMNIAS

    Frølund, Bente, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2020, Patent No. WO2020151795, 30 Jul 2020, Priority date 21 Jan 2019, Priority No. DK2019PA70040 20190121

    Research output: Patent

  4. Published

    A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues

    Wellendorph, Petrine, Jaroszewski, J. W., Hansen, S. H. & Franzyk, Henrik, 2003, In: European Journal of Medicinal Chemistry. 38, 1, p. 117-22 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24

    Christiansen, B., Wellendorph, Petrine & Bräuner, Hans, 24 Apr 2006, In: European Journal of Pharmacology. 536, 1-2, p. 98-101

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling

    Andersen, Jens Velde, Schousboe, Arne & Wellendorph, Petrine, 2023, In: Essays in Biochemistry. 67, 1, p. 77-91

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs

    Schousboe, Arne, Wellendorph, Petrine, Frølund, Bente, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 283-296 14 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  8. Published

    Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using (3)H-HOCPCA

    Klein, A. B., Bay, T., Villumsen, I. S., Falk-Petersen, C. B., Marek, A., Frølund, Bente, Clausen, Rasmus Prætorius, Hansen, H. D., Knudsen, Gitte Moos & Wellendorph, Petrine, Nov 2016, In: Neurochemistry International. 100, p. 138-145 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

    Griem-Krey, Nane, Klein, A. B., Herth, Matthias Manfred & Wellendorph, Petrine, 12 Mar 2019, In: Journal of visualized experiments : JoVE. 145, 11 p., e58879.

    Research output: Contribution to journal › Journal article › Communication

  10. Published

    Boganmeldelse: Bogsalonen Kubulus Alumni

    Wellendorph, Petrine, 2012

    Research output: Other contribution › Net publication - Internet publication › Communication

  11. Published

    CaMK2 modulators and their use in medicine

    Frølund, Bente, Shehata, M. A., Wellendorph, Petrine, Gauger, Stine Juul, Kuriyan, J., McSpadden, E. D., Poulsen, Lasse Brokmose, Fougiaxis, V. & Daraj, K., 2023, IPC No. A61K31/4164, A61K31/4178, A61P25/00, C07D277/06, C07D277/12, C07D277/56, C07D417/04, C07D417/10, Patent No. WO2023170024A1, 1 Jan 1970, Priority No. US202263318852P

    Research output: Patent

  12. Published

    CaMKIIα as a Promising Drug Target for Ischemic Grey Matter

    Griem-Krey, Nane, Clarkson, A. N. & Wellendorph, Petrine, 2022, In: Brain Sciences. 12, 12, 21 p., 1639.

    Research output: Contribution to journal › Review › Research › peer-review

  13. Published

    Characterization of GPRC6A: a 7TM receptor activated by L-alpha-amino acids and positively modulated by divalent cations

    Wellendorph, Petrine, Hansen, K. B., Christiansen, B., Burhenne, N., Balsgaard, A., Greenwood, J. R., Walter, B., Schmale, H., Egebjerg, J. & Bräuner, Hans, 2008, In: Fundamental and Clinical Pharmacology. Suppl. 2, p. 19

    Research output: Contribution to journal › Conference abstract in journal › Research

  14. Published

    Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor

    Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Thomsen, A. R. B., Phonekeo, K., Pedersen, D. S. & Bräuner, Hans, 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1489-1498

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Compounds for the treatment of acute brain injury

    Klein, A. B., Leurs, U., Houlton, J., Clausen, Rasmus Prætorius, Frølund, Bente, Clarkson, A. & Wellendorph, Petrine, 2020, Patent No. CN111989094, 24 Nov 2020, Priority date 1 Feb 2019, Priority No. PCT/DK2019/050041

    Research output: Patent

  16. Published

    Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefacts

    Jaroszewski, J. W., Olafsdottir, E. S., Wellendorph, Petrine, Christensen, J. L., Franzyk, Henrik, Somanadhan, B., Budnik, B. A., Jørgensen, L. B. & Clausen, V., 2002, In: Phytochemistry. 59, 5, p. 501-11 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Accepted/In press

    Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex

    Andersen, Jens Velde, Westi, Emil Winther, Griem-Krey, Nane, Skotte, Niels Henning, Schousboe, Arne, Aldana, Blanca & Wellendorph, Petrine, 2023, (Accepted/In press) In: Journal of Neurochemistry.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Delineation of the GPRC6A Receptor Signaling Pathways Using a Mammalian Cell Line Stably Expressing the Receptor

    Jacobsen, S. E., Nørskov-Lauritsen, L., Thomsen, A. R. B., Smajilovic, S., Wellendorph, Petrine, Larsson, N. H. P., Lehmann, A., Bhatia, V. K. & Bräuner, Hans, Nov 2013, In: Journal of Pharmacology and Experimental Therapeutics. 347, 2, p. 298-309 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Demonstration of the dynamic mass redistribution label-free technology as a useful cell-based pharmacological assay for endogenously expressed GABAA receptors

    Klein, A. B., Nittegaard-Nielsen, M., Christensen, J. T., Al-Khawaja, A. & Wellendorph, Petrine, 19 Nov 2015, In: MedChemComm. 7, p. 426-432 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids

    Wellendorph, Petrine, Hansen, K. B., Balsgaard, A., Greenwood, J. R., Egebjerg, J. & Bräuner, Hans, Mar 2005, In: Molecular Pharmacology. 67, 3, p. 589-97

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites

    Sabbatini, P., Wellendorph, Petrine, Høg, S., Pedersen, M. H. F., Bräuner, Hans, Martiny, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2010, In: Journal of Medicinal Chemistry. 53, 17, p. 6506-6510

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties

    Jensen, Anders A., Plath, N., Pedersen, M. H. F., Isberg, V., Krall, J., Wellendorph, Petrine, Stensbøl, T. B., Gloriam, David E., Krogsgaard-Larsen, Povl & Frølund, Bente, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1211-27 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes

    Falk-Petersen, C. B., Søgaard, R., Madsen, Kenneth Lindegaard, Klein, A. B., Frølund, Bente & Wellendorph, Petrine, Aug 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 2, p. 119-129 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Development of a medium throughput whole-cell microtiter plate Thr286 autophosphorylation assay for CaMKIIα using ELISA

    Palmelund, L. B., van Woerden, G. M., Bräuner, Hans & Wellendorph, Petrine, 2022, In: Journal of Pharmacological and Toxicological Methods. 118, 8 p., 107226.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain

    Tian, Yongsong, Shehata, M. A., Gauger, Stine Juul, Ng, C. K. L., Solbak, Sara Marie Øie, Thiesen, L., Bruus-Jensen, J., Krall, J., Bundgaard, C., Gibson, K. M., Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 9, p. 6656-6676

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

    Krall, J., Bavo, Francesco, Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Yongsong, Anglani, V., Kongstad, Kenneth Thermann, Petersen, Louise Piilgaard, Nielsen, Birgitte, Gloriam, David E., Kehler, J., Jensen, Anders A., Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 14 Mar 2019, In: Journal of Medicinal Chemistry. 62, 5, p. 2798-2813

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors

    Falk-Petersen, C. B., Tsonkov, T. M., Nielsen, M. S., Harpsøe, Kasper, Bundgaard, C., Frølund, Bente, Kristiansen, Uffe, Gloriam, David E. & Wellendorph, Petrine, 22 Jun 2020, In: Scientific Reports. 10, 1, 12 p., 10078.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Elucidating Pathway and Anesthetic Mechanism of Action of Clove Oil Nanoformulations in Fish

    Kheawfu, K., Pikulkaew, S., Wellendorph, Petrine, Jørgensen, Louise von Gersdorff, Rades, Thomas, Mullertz, Anette & Okonogi, S., 2022, In: Pharmaceutics. 14, 5, 13 p., 919.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Exploring the NCS-382 Scaffold for CaMKII alpha Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKII alpha Hub Domain

    Tian, Yongsong, Shehata, M. A., Gauger, Stine Juul, Veronesi, C., Hamborg, L., Thiesen, L., Bruus-Jensen, J., Royssen, J. S., Leurs, U., Larsen, A. S. G., Krall, J., Solbak, Sara Marie Øie, Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 22, p. 15066–15084

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Exploring the molecular determinants for subtype-selectivity of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogs as betaine/GABA transporter 1 (BGT1) substrate-inhibitors

    Kickinger, S., Al-Khawaja, A., Haugaard, A. S., Lie, M. E. K., Bavo, Francesco, Loeffler, R., Damgaard, M., Ecker, G. F., Frølund, Bente & Wellendorph, Petrine, 2020, In: Scientific Reports. 10, 1, 15 p., 12992.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex

    Andersen, Jens Velde, Jakobsen, Emil, Westi, Emil Winther, Lie, M. E. K., Voss, C. M., Aldana, Blanca, Schousboe, Arne, Wellendorph, Petrine, Bak, Lasse Kristoffer, Pinborg, Lars Hageman & Waagepetersen, Helle S., 2020, In: Glia. 68, 12, p. 2601-2612

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

    Giraudo, A., Krall, J., Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Fra forældreløs ligand til receptor kernefamilie

    Villumsen, I. S. & Wellendorph, Petrine, 2012, Årsskrift 2011-2012 Det Unge Akademi. København: Det Kongelige Danske Videnskabernes Selskab, Vol. 2012. p. 28-31

    Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Communication

  34. Published

    Functional modulation of a pH-sensitive ion channel by a transporter family

    Poulsen, Mette Homann, Xue, F., Maurya, S. R., Kickinger, Stefanie, Usher, Samuel George, Wellendorph, Petrine, Lundby, Alicia & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 249a

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  35. Published

    GABA transport cycle: beyond a GAT feeling

    Shahsavar, Azadeh & Wellendorph, Petrine, 2023, In: Nature Structural and Molecular Biology. 30, p. pages863–865

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  36. Published

    GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep

    Lie, M. E. K., Falk-Petersen, C. B., Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice

    Lie, M. E., Gowing, E. K., Johansen, N. B., Dalby, N. O., Thiesen, L., Wellendorph, Petrine & Clarkson, A. N., 1 Jan 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 1, p. 74-88 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    GHB receptor targets in the CNS: Focus on high-affinity binding sites

    Bay, T., Eghorn, L. F., Klein, A. B. & Wellendorph, Petrine, 2014, In: Biochemical Pharmacology. 87, 2, p. 220-228 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  40. Published

    Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function

    Jorgensen, S., Have, C. T., Underwood, C. R., Johansen, L. D., Wellendorph, Petrine, Gjesing, A. P., Jorgensen, C. V., Quan, S., Rui, G., Inoue, A., Linneberg, Allan René, Grarup, Niels, Jun, W., Pedersen, Oluf Borbye, Hansen, Torben & Bräuner, Hans, 2017, In: The Journal of Biological Chemistry. 292, 4, p. 1524-1534 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke

    Lie, M. E. K., Al-Khawaja, A., Damgaard, M., Haugaard, A. S., Schousboe, Arne, Clarkson, A. N. & Wellendorph, Petrine, 2017, Advances in Neurobiology. Vol. 16. p. 137-167 31 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  42. Published

    Hvordan virker Fantasy i hjernen?

    Høg, S., Wellendorph, Petrine, Greenwood, J. & Clausen, Rasmus Prætorius, 2005, In: Lægemiddelforskning. 2005, p. 16-17

    Research output: Contribution to journal › Journal article › Communication

  43. Hvorfor er det fedt at være forsker: Mysteriet som drivkraft: Blogindlæg

    Wellendorph, Petrine, 2012

    Research output: Other contribution › Net publication - Internet publication › Communication

  44. Published

    Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

    Lolli, M. L., Hansen, S. L., Rolando, B., Nielsen, Birgitte, Wellendorph, Petrine, Madsen, K., Larsen, O. M., Kristiansen, Uffe, Fruttero, R., Gasco, A. & Johansen, Tommy Nørskov, 2006, In: J. Med. Chem.. 49, p. 4442-4446 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method

    Frandsen, I. O., Boesgaard, M. W., Fidom, K., Hauser, Alexander Sebastian, Isberg, V., Bräuner, Hans, Wellendorph, Petrine & Gloriam, David E., 6 Jul 2017, In: Scientific Reports. 7, 1, 10 p., 4829.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Identification of the first highly selective inhibitor of human GABA transporter GAT3

    Damgaard, M., Al-Khawaja, A., Vogensen, S. B., Jurik, A., Sijm, M., Lie, M., Bæk, M. I., Rosenthal, E., Jensen, Anders A., Ecker, G. F., Frølund, Bente, Wellendorph, Petrine & Clausen, Rasmus Prætorius, 2015, In: A C S Chemical Neuroscience. 6, p. 1591-1599 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    In vitro and in vivo evidence for active brain uptake of the GHB analogue HOCPCA by the monocarboxylate transporter subtype 1

    Thiesen, L., Kehler, J., Clausen, Rasmus Prætorius, Frølund, Bente, Bundgaard, C. & Wellendorph, Petrine, 2015, In: Journal of Pharmacology and Experimental Therapeutics. 354, 2, p. 166-174 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia

    Lie, M. E., Gowing, E. K., Clausen, Rasmus Prætorius, Wellendorph, Petrine & Clarkson, A. N., 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 1, p. 166-173

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Kemogenomik: Receptoren set fra lægemiddelstoffets synspunkt

    Johansson, H., Jørgensen, T. B., Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Pedersen, D. S. & Bräuner, Hans, 2011, In: Dansk Kemi. 92, 11, p. 22-26

    Research output: Contribution to journal › Journal article › Research

  50. Published

    Kemogenomik: receptoren set fra lægemiddelstoffets synspunkt

    Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Pedersen, D. S. & Bräuner, Hans, Dec 2010, In: Lægemiddelforskning. 2010, p. 28-30

    Research output: Contribution to journal › Journal article › Communication

Previous 1 2 3 Next

ID: 1301791