Petrine Wellendorph
Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- Published
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction
Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 357-366Research output: Contribution to journal › Journal article › Research › peer-review
- Published
3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes
Karim, N., Gavande, N., Wellendorph, Petrine, Johnston, G. A. R., Hanrahan, J. R. & Chebib, M., 15 Dec 2011, In: Biochemical Pharmacology. 82, 12, p. 1971-1983Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A CLASS OF SMALL-MOLECULE COMPOUNDS AND THEIR PRODRUGS FOR INTERVENTION WITH CAMK2A, AND THEIR USE IN ACUTE BRAIN INJURIES AND CENTRAL HYPERSOMNIAS
Frølund, Bente, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2020, Patent No. WO2020151795, 30 Jul 2020, Priority date 21 Jan 2019, Priority No. DK2019PA70040 20190121Research output: Patent
- Published
A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues
Wellendorph, Petrine, Jaroszewski, J. W., Hansen, S. H. & Franzyk, Henrik, 2003, In: European Journal of Medicinal Chemistry. 38, 1, p. 117-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24
Christiansen, B., Wellendorph, Petrine & Bräuner, Hans, 24 Apr 2006, In: European Journal of Pharmacology. 536, 1-2, p. 98-101Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling
Andersen, Jens Velde, Schousboe, Arne & Wellendorph, Petrine, 2023, In: Essays in Biochemistry. 67, 1, p. 77-91Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs
Schousboe, Arne, Wellendorph, Petrine, Frølund, Bente, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 283-296 14 p. (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using (3)H-HOCPCA
Klein, A. B., Bay, T., Villumsen, I. S., Falk-Petersen, C. B., Marek, A., Frølund, Bente, Clausen, Rasmus Prætorius, Hansen, H. D., Knudsen, Gitte Moos & Wellendorph, Petrine, Nov 2016, In: Neurochemistry International. 100, p. 138-145 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
Griem-Krey, Nane, Klein, A. B., Herth, Matthias Manfred & Wellendorph, Petrine, 12 Mar 2019, In: Journal of visualized experiments : JoVE. 145, 11 p., e58879.Research output: Contribution to journal › Journal article › Communication
- Published
Boganmeldelse: Bogsalonen Kubulus Alumni
Wellendorph, Petrine, 2012Research output: Other contribution › Net publication - Internet publication › Communication
- Published
CaMK2 modulators and their use in medicine
Frølund, Bente, Shehata, M. A., Wellendorph, Petrine, Gauger, Stine Juul, Kuriyan, J., McSpadden, E. D., Poulsen, Lasse Brokmose, Fougiaxis, V. & Daraj, K., 2023, IPC No. A61K31/4164, A61K31/4178, A61P25/00, C07D277/06, C07D277/12, C07D277/56, C07D417/04, C07D417/10, Patent No. WO2023170024A1, 1 Jan 1970, Priority No. US202263318852PResearch output: Patent
- Published
CaMKIIα as a Promising Drug Target for Ischemic Grey Matter
Griem-Krey, Nane, Clarkson, A. N. & Wellendorph, Petrine, 2022, In: Brain Sciences. 12, 12, 21 p., 1639.Research output: Contribution to journal › Review › Research › peer-review
- Published
Characterization of GPRC6A: a 7TM receptor activated by L-alpha-amino acids and positively modulated by divalent cations
Wellendorph, Petrine, Hansen, K. B., Christiansen, B., Burhenne, N., Balsgaard, A., Greenwood, J. R., Walter, B., Schmale, H., Egebjerg, J. & Bräuner, Hans, 2008, In: Fundamental and Clinical Pharmacology. Suppl. 2, p. 19Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor
Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Thomsen, A. R. B., Phonekeo, K., Pedersen, D. S. & Bräuner, Hans, 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1489-1498Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compounds for the treatment of acute brain injury
Klein, A. B., Leurs, U., Houlton, J., Clausen, Rasmus Prætorius, Frølund, Bente, Clarkson, A. & Wellendorph, Petrine, 2020, Patent No. CN111989094, 24 Nov 2020, Priority date 1 Feb 2019, Priority No. PCT/DK2019/050041Research output: Patent
- Published
Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefacts
Jaroszewski, J. W., Olafsdottir, E. S., Wellendorph, Petrine, Christensen, J. L., Franzyk, Henrik, Somanadhan, B., Budnik, B. A., Jørgensen, L. B. & Clausen, V., 2002, In: Phytochemistry. 59, 5, p. 501-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex
Andersen, Jens Velde, Westi, Emil Winther, Griem-Krey, Nane, Skotte, Niels Henning, Schousboe, Arne, Aldana, Blanca & Wellendorph, Petrine, 2023, (Accepted/In press) In: Journal of Neurochemistry.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delineation of the GPRC6A Receptor Signaling Pathways Using a Mammalian Cell Line Stably Expressing the Receptor
Jacobsen, S. E., Nørskov-Lauritsen, L., Thomsen, A. R. B., Smajilovic, S., Wellendorph, Petrine, Larsson, N. H. P., Lehmann, A., Bhatia, V. K. & Bräuner, Hans, Nov 2013, In: Journal of Pharmacology and Experimental Therapeutics. 347, 2, p. 298-309 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Demonstration of the dynamic mass redistribution label-free technology as a useful cell-based pharmacological assay for endogenously expressed GABAA receptors
Klein, A. B., Nittegaard-Nielsen, M., Christensen, J. T., Al-Khawaja, A. & Wellendorph, Petrine, 19 Nov 2015, In: MedChemComm. 7, p. 426-432 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids
Wellendorph, Petrine, Hansen, K. B., Balsgaard, A., Greenwood, J. R., Egebjerg, J. & Bräuner, Hans, Mar 2005, In: Molecular Pharmacology. 67, 3, p. 589-97Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites
Sabbatini, P., Wellendorph, Petrine, Høg, S., Pedersen, M. H. F., Bräuner, Hans, Martiny, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2010, In: Journal of Medicinal Chemistry. 53, 17, p. 6506-6510Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties
Jensen, Anders A., Plath, N., Pedersen, M. H. F., Isberg, V., Krall, J., Wellendorph, Petrine, Stensbøl, T. B., Gloriam, David E., Krogsgaard-Larsen, Povl & Frølund, Bente, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1211-27 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes
Falk-Petersen, C. B., Søgaard, R., Madsen, Kenneth Lindegaard, Klein, A. B., Frølund, Bente & Wellendorph, Petrine, Aug 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 2, p. 119-129 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a medium throughput whole-cell microtiter plate Thr286 autophosphorylation assay for CaMKIIα using ELISA
Palmelund, L. B., van Woerden, G. M., Bräuner, Hans & Wellendorph, Petrine, 2022, In: Journal of Pharmacological and Toxicological Methods. 118, 8 p., 107226.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain
Tian, Yongsong, Shehata, M. A., Gauger, Stine Juul, Ng, C. K. L., Solbak, Sara Marie Øie, Thiesen, L., Bruus-Jensen, J., Krall, J., Bundgaard, C., Gibson, K. M., Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 9, p. 6656-6676Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites
Krall, J., Bavo, Francesco, Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Yongsong, Anglani, V., Kongstad, Kenneth Thermann, Petersen, Louise Piilgaard, Nielsen, Birgitte, Gloriam, David E., Kehler, J., Jensen, Anders A., Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 14 Mar 2019, In: Journal of Medicinal Chemistry. 62, 5, p. 2798-2813Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors
Falk-Petersen, C. B., Tsonkov, T. M., Nielsen, M. S., Harpsøe, Kasper, Bundgaard, C., Frølund, Bente, Kristiansen, Uffe, Gloriam, David E. & Wellendorph, Petrine, 22 Jun 2020, In: Scientific Reports. 10, 1, 12 p., 10078.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elucidating Pathway and Anesthetic Mechanism of Action of Clove Oil Nanoformulations in Fish
Kheawfu, K., Pikulkaew, S., Wellendorph, Petrine, Jørgensen, Louise von Gersdorff, Rades, Thomas, Mullertz, Anette & Okonogi, S., 2022, In: Pharmaceutics. 14, 5, 13 p., 919.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the NCS-382 Scaffold for CaMKII alpha Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKII alpha Hub Domain
Tian, Yongsong, Shehata, M. A., Gauger, Stine Juul, Veronesi, C., Hamborg, L., Thiesen, L., Bruus-Jensen, J., Royssen, J. S., Leurs, U., Larsen, A. S. G., Krall, J., Solbak, Sara Marie Øie, Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 22, p. 15066–15084Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the molecular determinants for subtype-selectivity of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogs as betaine/GABA transporter 1 (BGT1) substrate-inhibitors
Kickinger, S., Al-Khawaja, A., Haugaard, A. S., Lie, M. E. K., Bavo, Francesco, Loeffler, R., Damgaard, M., Ecker, G. F., Frølund, Bente & Wellendorph, Petrine, 2020, In: Scientific Reports. 10, 1, 15 p., 12992.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex
Andersen, Jens Velde, Jakobsen, Emil, Westi, Emil Winther, Lie, M. E. K., Voss, C. M., Aldana, Blanca, Schousboe, Arne, Wellendorph, Petrine, Bak, Lasse Kristoffer, Pinborg, Lars Hageman & Waagepetersen, Helle S., 2020, In: Glia. 68, 12, p. 2601-2612Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters
Giraudo, A., Krall, J., Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fra forældreløs ligand til receptor kernefamilie
Villumsen, I. S. & Wellendorph, Petrine, 2012, Årsskrift 2011-2012 Det Unge Akademi. København: Det Kongelige Danske Videnskabernes Selskab, Vol. 2012. p. 28-31Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Communication
- Published
Functional modulation of a pH-sensitive ion channel by a transporter family
Poulsen, Mette Homann, Xue, F., Maurya, S. R., Kickinger, Stefanie, Usher, Samuel George, Wellendorph, Petrine, Lundby, Alicia & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 249aResearch output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
GABA transport cycle: beyond a GAT feeling
Shahsavar, Azadeh & Wellendorph, Petrine, 2023, In: Nature Structural and Molecular Biology. 30, p. pages863–865Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep
Lie, M. E. K., Falk-Petersen, C. B., Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice
Lie, M. E., Gowing, E. K., Johansen, N. B., Dalby, N. O., Thiesen, L., Wellendorph, Petrine & Clarkson, A. N., 1 Jan 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 1, p. 74-88 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, , 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GHB receptor targets in the CNS: Focus on high-affinity binding sites
Bay, T., Eghorn, L. F., Klein, A. B. & Wellendorph, Petrine, 2014, In: Biochemical Pharmacology. 87, 2, p. 220-228 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function
Jorgensen, S., Have, C. T., Underwood, C. R., Johansen, L. D., Wellendorph, Petrine, Gjesing, A. P., Jorgensen, C. V., Quan, S., Rui, G., Inoue, A., Linneberg, Allan René, Grarup, Niels, Jun, W., Pedersen, Oluf Borbye, Hansen, Torben & Bräuner, Hans, 2017, In: The Journal of Biological Chemistry. 292, 4, p. 1524-1534 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke
Lie, M. E. K., Al-Khawaja, A., Damgaard, M., Haugaard, A. S., Schousboe, Arne, Clarkson, A. N. & Wellendorph, Petrine, 2017, Advances in Neurobiology. Vol. 16. p. 137-167 31 p. (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Hvordan virker Fantasy i hjernen?
Høg, S., Wellendorph, Petrine, Greenwood, J. & Clausen, Rasmus Prætorius, 2005, In: Lægemiddelforskning. 2005, p. 16-17Research output: Contribution to journal › Journal article › Communication
Hvorfor er det fedt at være forsker: Mysteriet som drivkraft: Blogindlæg
Wellendorph, Petrine, 2012Research output: Other contribution › Net publication - Internet publication › Communication
- Published
Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds
Lolli, M. L., Hansen, S. L., Rolando, B., Nielsen, Birgitte, Wellendorph, Petrine, Madsen, K., Larsen, O. M., Kristiansen, Uffe, Fruttero, R., Gasco, A. & Johansen, Tommy Nørskov, 2006, In: J. Med. Chem.. 49, p. 4442-4446 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method
Frandsen, I. O., Boesgaard, M. W., Fidom, K., Hauser, Alexander Sebastian, Isberg, V., Bräuner, Hans, Wellendorph, Petrine & Gloriam, David E., 6 Jul 2017, In: Scientific Reports. 7, 1, 10 p., 4829.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of the first highly selective inhibitor of human GABA transporter GAT3
Damgaard, M., Al-Khawaja, A., Vogensen, S. B., Jurik, A., Sijm, M., Lie, M., Bæk, M. I., Rosenthal, E., Jensen, Anders A., Ecker, G. F., Frølund, Bente, Wellendorph, Petrine & Clausen, Rasmus Prætorius, 2015, In: A C S Chemical Neuroscience. 6, p. 1591-1599 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro and in vivo evidence for active brain uptake of the GHB analogue HOCPCA by the monocarboxylate transporter subtype 1
Thiesen, L., Kehler, J., Clausen, Rasmus Prætorius, Frølund, Bente, Bundgaard, C. & Wellendorph, Petrine, 2015, In: Journal of Pharmacology and Experimental Therapeutics. 354, 2, p. 166-174 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia
Lie, M. E., Gowing, E. K., Clausen, Rasmus Prætorius, Wellendorph, Petrine & Clarkson, A. N., 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 1, p. 166-173Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kemogenomik: Receptoren set fra lægemiddelstoffets synspunkt
Johansson, H., Jørgensen, T. B., Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Pedersen, D. S. & Bräuner, Hans, 2011, In: Dansk Kemi. 92, 11, p. 22-26Research output: Contribution to journal › Journal article › Research
- Published
Kemogenomik: receptoren set fra lægemiddelstoffets synspunkt
Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Pedersen, D. S. & Bräuner, Hans, Dec 2010, In: Lægemiddelforskning. 2010, p. 28-30Research output: Contribution to journal › Journal article › Communication
ID: 1301791
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Kemogenomik: Receptoren set fra lægemiddelstoffets synspunkt
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Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor
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Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method
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