Povl Krogsgaard-Larsen

Povl Krogsgaard-Larsen

Professor, emeritus


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  1. Published

    (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors

    Ahmadian, H., Nielsen, Birgitte, Bräuner, Hans, Johansen, Tommy Nørskov, Stensbøl, T. B., Sløk, F. A., Sekiyama, N., Nakanishi, S., Krogsgaard-Larsen, Povl & Madsen, Ulf, 24 Oct 1997, In: Journal of Medicinal Chemistry. 40, 22, p. 3700-5

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity

    Bolvig, T., Larsson, O. M., Pickering, Darryl S, Nelson, N., Falch, E., Krogsgaard-Larsen, Povl, Schousboe, Arne & Pickering, Darryl S, 1999, In: European Journal of Pharmacology. 375, 1-3, p. 367-74 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABA(A) receptors

    Brehm, L., Ebert, B., Kristiansen, Uffe, Wafford, K. A., Kemp, J. A. & Krogsgaard-Larsen, Povl, 1997, In: European Journal of Medicinal Chemistry. 32, 4, p. 357-363 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology

    Brehm, L., Greenwood, J. R., Hansen, K. B., Nielsen, Birgitte, Egebjerg, J., Stensbøl, T. B., Bräuner, Hans, Sløk, F. A., Kronborg, T. T. A. & Krogsgaard-Larsen, Povl, 10 Apr 2003, In: Journal of Medicinal Chemistry. 46, 8, p. 1350-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Crystal Structure and Quantum Chemical Ab Initio Calculations of Ibotenic Acid, an Excitatory Amino Acid Receptor Agonist

    Brehm, L., Frydenvang, Karla Andrea, Krogsgaard-Larsen, Povl & Liljefors, T., 1998, In: Structural Chemistry. 9, 2, p. 149-155 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Structural and stereochemical requirements for interactions with subtypes of central excitatory amino acid receptors

    Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B., Madsen, Ulf, Jørgensen, Flemming Steen, Hansen, J. J. & Krogsgaard-Larsen, Povl, 1990, Frontiers in Drug Research; Alfred Benzon Symposium 28. Jensen, B., Jørgensen, F. S. & Kofod, H. (eds.). Copenhagen: Munksgaard , p. 92-105 14 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  7. Published

    Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA

    Brehm, L., Greenwood, J. R., Sløk, F. A., Holm, M. M., Nielsen, Birgitte, Geneser, U., Stensbøl, T. B., Bräuner, Hans, Begtrup, M., Egebjerg, J. & Krogsgaard-Larsen, Povl, Aug 2004, In: Chirality. 16, 7, p. 452-66

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors

    Brier, T. J., Mellor, I. R., Tikhonov, D. B., Neagoe, I., Shao, Z., Brierley, M. J., Strømgaard, Kristian, Jaroszewski, J. W., Krogsgaard-Larsen, Povl & Usherwood, P. N. R., Oct 2003, In: Molecular Pharmacology. 64, 4, p. 954-964 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain

    Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., O'Hara, P. & Krogsgaard-Larsen, Povl, 1999, In: Journal of Biological Chemistry. 274, 26, p. 18382-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D

    Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., Larsen, Birger Brodin, Krogsgaard-Larsen, Povl & O'Hara, P., 2001, In: BBA General Subjects. 1518, 3, p. 237-48 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor

    Bräuner, Hans, Jensen, Anders A. & Krogsgaard-Larsen, Povl, 1999, In: NeuroReport. 10, 18, p. 3923-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Ligands for glutamate receptors: design and therapeutic prospects

    Bräuner, Hans, Egebjerg, J., Nielsen, E. O., Madsen, Ulf & Krogsgaard-Larsen, Povl, 13 Jul 2000, In: Journal of Medicinal Chemistry. 43, 14, p. 2609-45

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2

    Bräuner, Hans, Hermit, M. B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl & Johansen, Tommy Nørskov, 6 Oct 2000, In: European Journal of Pharmacology. 406, 1, p. 41-4

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Functional partial agonism at cloned human muscarinic acetylcholine receptors

    Bräuner, Hans, Ebert, B., Brann, M. R., Falch, E. & Krogsgaard-Larsen, Povl, 10 Oct 1996, In: European Journal of Pharmacology. 313, 1-2, p. 145-50

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors

    Bräuner, Hans, Ebert, B., Brann, M. R., Falch, E. & Krogsgaard-Larsen, Povl, 9 Jun 1995, In: Journal of Medicinal Chemistry. 38, 12, p. 2188-95

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid

    Bräuner, Hans, Sløk, F. A., Skjaerbaek, N., Ebert, B., Sekiyama, N., Nakanishi, S. & Krogsgaard-Larsen, Povl, 2 Aug 1996, In: Journal of Medicinal Chemistry. 39, 16, p. 3188-94

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain

    Bräuner, Hans & Krogsgaard-Larsen, Povl, 15 Apr 2000, In: Genomics. 65, 2, p. 121-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Functional pharmacology of cloned heterodimeric GABA-B receptors expressed in mammalian cells

    Bräuner, Hans & Krogsgaard-Larsen, Povl, Dec 1999, In: British Journal of Pharmacology. 128, 7, p. 1370-4

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors

    Bräuner, Hans, Nielsen, Birgitte, Stensbøl, T. B., Johansen, Tommy Nørskov, Skjaerbaek, N. & Krogsgaard-Larsen, Povl, 24 Sep 1997, In: European Journal of Pharmacology. 335, 2-3, p. R1-3

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors

    Bräuner, Hans, Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 5 Jun 1998, In: European Journal of Pharmacology. 350, 2-3, p. 311-6

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors

    Bräuner, Hans & Krogsgaard-Larsen, Povl, Jan 1998, In: British Journal of Pharmacology. 123, 2, p. 269-74

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol

    Bunch, Lennart, Norrby, P., Frydenvang, Karla Andrea, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2001, In: Organic Letters. 3, 3, p. 433-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Synthesis and receptor binding affinity of new selective GluR5 ligands

    Bunch, Lennart, Johansen, T. H., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl & Madsen, Ulf, Apr 2001, In: Bioorganic & Medicinal Chemistry. 9, 4, p. 875-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Subtype selective kainic acid receptor agonists: discovery and approaches to rational design

    Bunch, Lennart & Krogsgaard-Larsen, Povl, 2009, In: Medicinal Research Reviews. 29, 1, p. 3-28

    Research output: Contribution to journal › Review › Research › peer-review

  25. Published

    Mixed cyano-gilman cuprates - Advances in conjugate addition to alpha,beta-unsaturated pyroglutaminol

    Bunch, Lennart, Krogsgaard-Larsen, Povl & Madsen, Ulf, Jan 2002, In: Synthesis. 1, p. 31-33

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: Application to the synthesis of thioibotenic acid

    Bunch, Lennart, Krogsgaard-Larsen, Povl & Madsen, Ulf, 5 Apr 2002, In: Journal of Organic Chemistry. 67, 7, p. 2375-2377

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue

    Bunch, Lennart, Liljefors, T., Greenwood, J. R., Frydenvang, Karla Andrea, Bräuner, Hans, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2003, In: Journal of Organic Chemistry. 68, 4, p. 1489-95 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Conformational analysis and molecular modelling of a partial GABA(A) agonist and a glycine antagonist related to the GABA(A) agonist, THIP

    Byberg Buur, J. R., Hjeds, H., Krogsgaard-Larsen, Povl & Jørgensen, Flemming Steen, 1 Dec 1993, In: Drug Design and Discovery. 10, 3, p. 213-229 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Excitatory amino acid agonists and partial agonists

    Christensen, I. T., Reinhardt, A., Nielsen, B., Ebert, B., Madsen, Ulf, Nielsen, E. O., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: Drug Design and Delivery. 5, 1, p. 57-71 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid

    Christensen, I. T., Ebert, B., Madsen, Ulf, Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 18 Sep 1992, In: Journal of Medicinal Chemistry. 35, 19, p. 3512-3519 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Excitatory Amino acid agonists and parital agonists

    Christensen, I. T., Reinhardt, A., Nielsen, Birgitte, Ebert, B., Madsen, Ulf, Nielsen, E. Ø., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: drug design and delivery. 5, p. 57-71 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Preparations of deuterium labelled guvacine and isoguvacine

    Christensen, Søren Brøgger & Krogsgaard-Larsen, Povl, 1 Jan 1980, In: Journal of Labelled Compounds and Radiopharmaceuticals. 17, 2, p. 191-202 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid

    Clausen, Rasmus Prætorius, Bräuner, Hans, Greenwood, J. R., Hermit, M. B., Stensbøl, T. B., Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 12 Sep 2002, In: Journal of Medicinal Chemistry. 45, 19, p. 4240-5

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Design, synthesis, and characterisation of selective GABA transport inhibitors

    Clausen, Rasmus Prætorius, Moltzen, E., Perregaard, J., Lenz, S., Sanchez, S., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O., White, H., Schousboe, Arne & Krogsgaard-Larsen, Povl, Aug 2005, In: Journal of Neurochemistry. 94, p. 150-150

    Research output: Contribution to journal › Conference abstract in journal › Research

  35. Published

    Structure-Activity Relationship and Pharmacology of γ-Aminobutyric Acid (GABA) Transport Inhibitors

    Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 1 Dec 2006, GABA. Enna, S. J. (ed.). p. 265-284 20 p. (Advances in Pharmacology, Vol. 54).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  36. Published

    Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino- 4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues

    Clausen, Rasmus Prætorius, Moltzen, E. K., Perregaard, J., Lenz, S., Sanchez, C., Falch, E., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 2005, In: Bioorganic & Medicinal Chemistry. 13, p. 895–908

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Et bud på fremtidens lægemidler mod epilepsi.

    Clausen, Rasmus Prætorius, Larsson, O. M., Greenwood, J. & Krogsgaard-Larsen, Povl, 2001, In: Lægemiddelforskning. p. 20-21

    Research output: Contribution to journal › Journal article › Communication

  38. Published

    Structure–Activity Relationship and Pharmacology of γ‐Aminobutyric Acid Transport Inhibitor

    Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, GABA. Enna, S. (ed.). Vol. 54. p. 265–284 (Advances in Pharmacology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  39. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

    Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Synthesis and pharmacology of 2-amino-4-(4-hydroxy-1,2,5-thiadiazol-3-yl)butyric acid.

    Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, Aug 2001, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 222, p. U660-U660

    Research output: Contribution to journal › Conference article › Research

  41. Published

    Analogues of the low-efficacy partial GABAA agonist 4-PIOL. Syntheses and in vitro pharmacological studies

    De Amici, M., Frølund, Bente, Hjeds, H. & Krogsgaard-Larsen, Povl, Sep 1991, In: European Journal of Medicinal Chemistry. 26, 6, p. 625-631 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Analogues of the Low-efficacy Partial GABA-A Agonist 4-PIOL. Synthesis and in vitro Pharmacological Studies

    De Amici, M., Frølund, Bente, Hjeds, H. & Krogsgaard-Larsen, Povl, 1991, In: European Journal of Medicinal Chemistry. 26, p. 625–631

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Subtype-selective excitatory amino acid receptor agonists and antagonists derived from ibotenic acid

    Ebert, B., Lund, Trine Meldgaard, Madsen, Ulf, Brehm, L. & Krogsgaard-Larsen, Povl, 1992, New leads and targets in drug research: Alfred Benzon Symposium 33. Krogsgaard-Larsen, P., Christensen, S. B. & Kofod, H. (eds.). Copenhagen, p. 340-351 11 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  44. Published

    Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA

    Ebert, B., Madsen, Ulf, Lund, Trine Meldgaard, Lenz, S. M. & Krogsgaard-Larsen, Povl, Jun 1994, In: Neurochemistry International. 24, 6, p. 507-15 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Molecular pharmacology of cortical and spinal AMPA receptors

    Ebert, B., Madsen, Ulf, Lund, Trine Meldgaard, Holm, T. & Krogsgaard-Larsen, Povl, 1 Jan 1992, In: Molecular Neuropharmacology. 2, 1, p. 47-49 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Equilibrium binding characteristics of [3H]thiomuscimol

    Ebert, B., Frølund, Bente, Diemer, N. & Krogsgaard-Larsen, Povl, 1999, In: Neurochemistry International. 34, p. 427–434

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and Analogues

    Falch, E., Frølund, Bente, Perregaard, Sanchez, C., Søkilde, B., Buur, A., Hansen, A., Frydenvang, Karla Andrea, Brehm, L., Bolvig, T., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 1999, In: Journal of Medicinal Chemistry. 42, p. 5402–5414

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships

    Falch, E., Brehm, L., Mikkelsen, I., Johansen, Tommy Nørskov, Skjærbæk, N., Nielsen, Birgitte, Stensbøl, T. B., Ebert, B. & Krogsgaard-Larsen, Povl, 1998, In: Journal of Medicinal Chemistry. 41, p. 2513-2523 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    (-)-(R)-5,5-dimethylmorpholinyl-2-acetic acid ethyl ester hydrochloride, C10H20NO3+.Cl-

    Frydenvang, Karla Andrea, Enna, S. J. & Krogsgaard-Larsen, Povl, 15 Aug 1997, In: Acta Crystallographica Section C: Crystal Structure Communications. 53, 8, p. 1088-1091 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Structural characteristics of isoxazol-3-ol and isothiazol-3-ol, carboxy group bioisosteres examined by X-ray crystallography and ab initio calculations

    Frydenvang, Karla Andrea, Matzen, L., Norrby, P. O., Sløk, F. A., Liljefors, T., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Sep 1997, In: Journal of the Chemical Society. Perkin Transactions 2. 9, p. 1783-1791 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Stereospecific GABA-B receptor antagonism

    Frydenvang, Karla Andrea, Frølund, Bente, Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 1996, GABA, receptors, transporters and metabolism. Tanaka, C. & Bowery, N. G. (eds.). Basel: Birkhäuser Verlag

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  52. Published

    GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer

    Frydenvang, Karla Andrea, Kristiansen, Uffe, Frølund, Bente, Herdeis, C. & Krogsgaard-Larsen, Povl, 1995, In: Chirality. 7, p. 526–533

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    GABAB antagonists: resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen

    Frydenvang, Karla Andrea, Hansen, J. J., Krogsgaard-Larsen, Povl, Mitrovic, A., Tran, H., Drew, C. A. & Johnston, G. A., 1994, In: Chirality. 6, 7, p. 583-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid

    Frydenvang, Karla Andrea, Pickering, Darryl S, Greenwood, J. R., Krogsgaard-Larsen, N., Brehm, L., Nielsen, Birgitte, Vogensen, S. B., Hald, H., Kastrup, Jette Sandholm Jensen, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 10 Nov 2010, In: Journal of Medicinal Chemistry. 53, 23, p. 8354-8361

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Peptide and protein drug delivery : proceedings of a symposium held at the Royal Danish Academy of Sciences and Letters, August 17-21, 1997: Alfred Benzon Symposium, 43

    Frøkjær, Sven, Christrup, Lona Louring, Krogsgaard-Larsen, Povl & Alfred Benzon, F., 1998, Copenhagen: Munksgaard .

    Research output: Book/Report › Book › Research

  56. Published

    A novel class of potent 3-isoxazolol GABAA antagonists: Design, systhesis, and pharmacology [3]

    Frølund, Bente, Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 28 Dec 2000, In: Journal of Medicinal Chemistry. 43, 26, p. 4930-4933 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  57. Published

    Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABAA antagonists: Synthesis, pharmacology, and molecular modeling

    Frølund, Bente, Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, Uffe, Nielsen, Birgitte, Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, Povl & Liljefors, T., 27 Jan 2005, In: Journal of Medicinal Chemistry. 48, 2, p. 427-439 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Novel Class of Potent 4-Arylalkyl Substituted 3-Isoxazolol GABAA Antagonists:Synthesis, Pharmacology, and Molecular Modeling

    Frølund, Bente, Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, Uffe, Sanchez, C., Krogsgaard-Larsen, Povl & Liljefors, T., 2002, In: Journal of Medicinal Chemistry. 45, p. 2454–2468

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    GABAA agonists: Resolution and pharmacology of (+)‐ and (−)‐isoguvacine oxide

    Frølund, Bente, Jeppesen, L., Krogsgaard-Larsen, Povl & Hansen, J. J., 1995, In: Chirality. 7, 6, p. 434-438 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    GABA-A Receptor Agonists, Partial Agonists and Antagonists

    Frølund, Bente, Krogsgaard-Larsen, Povl & Ebert, B., 1996, The GABA Receptors. 2nd ed. Humana Press

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  61. Published

    GABAA receptor ligands and their therapeutic potentials

    Frølund, Bente, Ebert, B., Kristiansen, Uffe, Liljefors, T. & Krogsgaard-Larsen, Povl, 2002, In: Current Topics in Medicinal Chemistry. 2

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Partial GABAA Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol

    Frølund, Bente, Kristiansen, Uffe, Brehm, L., Hansen, A. B., Krogsgaard-Larsen, Povl & Falch, E., 1 Aug 1995, In: Journal of Medicinal Chemistry. 38, 17, p. 3287-3296 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Characterization of the GABAA Receptor Recognition Site Through Ligand Design and Pharmacophore Modeling

    Frølund, Bente, Jørgensen, A. T., Liljefors, T., Mortensen, M. & Krogsgaard-Larsen, Povl, 2004, Molecular Neuropharmacology: Strategies and Methods. Schousboe, A. & Bräuner-Osborne, H. (eds.). Humana Press

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  64. Published

    A Novel Class of Potent 3-Isoxazolol GABAA Antagonists: Design, Synthesis, and Pharmacology

    Frølund, Bente, Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 2000, In: Journal of Medicinal Chemistry. 43, p. 4930–4933

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects

    Frølund, Bente, Krogsgaard-Larsen, Povl, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., 1997, In: European Journal of Pharmaceutical Sciences. 4, p. 355–384

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    A novel selective γ-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS

    Frølund, Bente, Clausen, Rasmus Prætorius, Larsson, O. M., Schousboe, Arne, Krogsgaard-Larsen, Povl & White, H. S., 2006, In: Neurochemistry International. 48, p. 637–642

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    AMPA Receptor Agonists. Synthesis, Protolytic Properties and Pharmacology of 3-Isothiazolol Bioisosteres of Glutamic Acid

    Frølund, Bente, Matzen, L., Engesgaard, A., Ebert, B., Didriksen, M., Krogsgaard-Larsen, Povl & Jaroszewski, J., 1997, In: Journal of Medicinal Chemistry. 40, p. 520–527

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABAA antagonists

    Frølund, Bente, Tagmose, L., Jørgensen, A. T., Kristiansen, Uffe, Stensbøl, T. B., Liljefors, T. & Krogsgaard-Larsen, Povl, 2003, In: European Journal of Medicinal Chemistry. 38, p. 447–449

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    GABAA Agonists: Resolution and Pharmacology of (+)- and (-)-Isoguvacine Oxide

    Frølund, Bente, Jeppesen, L., Krogsgaard-Larsen, Povl & Hansen, J. J., 1995, In: Chirality. 7, p. 434–438

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    4-PIOL, a low-efficacy partial GABA-A agonist

    Frølund, Bente, Kristiansen, Uffe, Nathan, T., Falch, E., Lambert, J. D. C. & Krogsgaard-Larsen, Povl, 1991, Drug Research related to Neuroactive Amino Acids. Munksgaard

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  71. Published

    Partial GABAA Receptor agonists. Synthesis and in vitro Pharmacology

    Frølund, Bente, Kristiansen, Uffe, Brehm, L., Hansen, A. B., Krogsgaard-Larsen, Povl & Falch, E., 1995, In: Journal of Medicinal Chemistry. 38, p. 3287–3296

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    GABA(A) receptor ligands and their therapeutic potentials.

    Frølund, Bente, Ebert, B., Kristiansen, Uffe, Liljefors, T. & Krogsgaard-Larsen, Povl, Aug 2002, In: Current Topics in Medicinal Chemistry. 2, 8, p. 817-832 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  73. Published

    Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABAA antagonists

    Frølund, Bente, Tagmose, L., Jørgensen, A. T., Kristiansen, Uffe, Stensbøl, T. B., Liljefors, T. & Krogsgaard-Larsen, Povl, 1 Apr 2003, In: European Journal of Medicinal Chemistry. 38, 4, p. 447-449 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    Potent 4-Aryl- or 4-Arylalkyl-Substituted 3-Isoxazolol GABAA Antagonists: Synthesis, Pharmacology, and Molecular Modeling

    Frølund, Bente, Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, U., Nielsen, Birgitte, Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, Povl & Liljefors, T., 2005, In: Journal of Medicinal Chemistry. 48, p. 427–439

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAC receptor antagonists

    Frølund, Bente, Krehan, D., Krogsgaard-Larsen, Povl, Kehler, J., Johnston, G. A. R. & Chebib, M., 2003, In: Neurochemistry International. 42, p. 561–565

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABAA antagonists: Synthesis, pharmacology, and molecular modeling

    Frølund, Bente, Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, Uffe, Sanchez, C., Krogsgaard-Larsen, Povl & Liljefors, T., 6 Jun 2002, In: Journal of Medicinal Chemistry. 45, 12, p. 2454-2468 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Synthesis and receptor binding of 5-amino[3H]2methyl-3-isothiazolol ([3H]thiomuscimol), a specific GABAa agonist photoaffinity label

    Frølund, Bente, Ebert, B., Lawrence, L. W., Hurt, S. D. & Krogsgaard-Larsen, Povl, 1995, In: Journal of Labelled Compounds and Radiopharmaceuticals. 36, p. 877–889

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology

    Frølund, Bente, Greenwood, J. R., Holm, M. M., Egebjerg, J., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans, Stensbøl, T. B. & Krogsgaard-Larsen, Povl, 15 Sep 2005, In: Bioorganic & Medicinal Chemistry. 13, 18, p. 5391-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships

    Frølund, Bente, Jensen, L. S., Storustovu, S. I., Stensbøl, T. B., Ebert, B., Kehler, J., Krogsgaard-Larsen, Povl & Liljefors, T., 2007, In: Journal of Medicinal Chemistry. 50, 8, p. 1988-1992

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Ligands for the GABA recognition site at the GABAA receptor: Structure-activity studies

    Frølund, Bente, Kristiansen, Uffe, Krogsgaard-Larsen, Povl & Liljefors, T., 2008, Chemistry and molecular aspects of drug design and action. Rekka, E. A. & Kourounakis, P. N. (eds.). Boca Raton, Fl: CRC Press, p. 139-147

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  81. Published

    Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction

    Gottschalk, M., Bach, Anders, Hansen, J. L., Krogsgaard-Larsen, Povl, Kristensen, Anders Skov & Strømgaard, Kristian, 2009, In: Neurochemical Research. 34, 10, p. 1729-1737

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs

    Guldbrandt, M., Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Nielsen, Birgitte, Karla, R., Santi, F., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2002, In: Chirality. 14, 4, p. 351-63 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    AMPA receptor agonists: structural, conformational and stereochemical aspects

    Hansen, J., Jørgensen, Flemming Steen, Lund, Trine Meldgaard, Nielsen, Birgitte, Reinhardt, A., Breum, I., Brehm, L. & Krogsgaard-Larsen, Povl, 1992, Excitatory Amino Acid Receptors. Krogsgaard-Larsen, P. & Hansen, J. J. (eds.). Ellis Horwood: Chichester, 30 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  84. Published

    Isoxazole amino acids as glutamic acid receptor agonists: conformational and stereochemical aspects

    Hansen, J. J., Madsen, Ulf, Nielsen, E. Ø., Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 1989, New Methods in Drug Research. Makriayannis, A. (ed.). Barcelona: Prous Scientific Publishers, Vol. 3. p. 73-101 29 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  85. Published

    Excitatory Amino acid agonists: Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid

    Hansen, J. J., Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Brehm, L., Nielsen, E. Ø. & Curtis, D. R., 1989, In: Journal of Medicinal Chemistry. 32, p. 2254-2260 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Excitatory Amino acid receptor agonists: enantiomeric resolutions by use of enzymes and chiral HPLC

    Hansen, J. J., Nielsen, Birgitte, Reinhardt, A. & Krogsgaard-Larsen, Povl, 1990, In: Acta Pharmaceutica Nordica. 2, p. 185-192 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors

    Hermit, M. B., Greenwood, J. R., Nielsen, Birgitte, Bunch, Lennart, Jørgensen, Charlotte Grube, Vestergaard, H. T., Stensbøl, T. B., Sanchez, C., Krogsgaard-Larsen, Povl, Madsen, Ulf & Bräuner, Hans, 23 Feb 2004, In: European Journal of Pharmacology. 486, 3, p. 241-50

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors

    Hoestgaard-Jensen, K., O'Connor, R. M., Dalby, N. O., Simonsen, C., Finger, B. C., Golubeva, A., Hammer, H., Bergmann, M. L., Kristiansen, Uffe, Krogsgaard-Larsen, Povl, Bräuner, Hans, Ebert, B., Frølund, Bente, Cryan, J. F. & Jensen, Anders A., Oct 2013, In: British Journal of Pharmacology. 170, 4, p. 919-32 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Probing α4βδ GABAA Receptor Heterogeneity: Differential Regional Effects of a Functionally Selective α4β1δ/α4β3δ Receptor Agonist on Tonic and Phasic Inhibition in Rat Brain

    Hoestgaard-Jensen, K., Dalby, N. O., Krall, J., Hammer, H., Krogsgaard-Larsen, Povl, Frølund, Bente & Jensen, Anders A., 2014, In: Journal of Neuroscience. 34, 49, p. 16256-16272 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Structure-Activity Relationships of Selective GABA Uptake Inhibitors

    Høg, S., Greenwood, J., Madsen, K. B., Larsson, O. M., Frølund, Bente, Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2006, In: Current Topics in Medicinal Chemistry. 6, 17, p. 1861–1882

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Neuroactive Polyamine Wasp Toxins: Nuclear Magnetic Resonance Spectroscopic Analysis of the Proteolytic Properties of Philantotoxin-343

    Jaroszewski, J., Matzen, L., Frølund, Bente & Krogsgaard-Larsen, Povl, 1996, In: Journal of Medicinal Chemistry. 39, p. 515–521

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Neuroactive polyamine wasp toxins: Nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin-343

    Jaroszewski, J. W., Matzen, L., Frølund, Bente & Krogsgaard-Larsen, Povl, 19 Jan 1996, In: Journal of Medicinal Chemistry. 39, 2, p. 515-521 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties

    Jensen, Anders A., Plath, N., Pedersen, M. H. F., Isberg, V., Krall, J., Wellendorph, Petrine, Stensbøl, T. B., Gloriam, David E., Krogsgaard-Larsen, Povl & Frølund, Bente, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1211-27 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors

    Jensen, Anders A., Mikkelsen, I. B., Frølund, Bente, Frydenvang, Karla Andrea, Brehm, L., Jaroszewski, J. W., Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2004, In: European Journal of Pharmacology. 497, 2, p. 125-37 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor

    Jensen, Anders A., Madsen, B. E., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2001, In: European Journal of Pharmacology. 417, 3, p. 177-80 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity

    Jensen, Anders A., Sheppard, P. O., O'Hara, P. J., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: European Journal of Pharmacology. 397, 2-3, p. 247-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor

    Jensen, Anders A., Spalding, T. A., Burstein, E. S., Sheppard, P. O., O'Hara, P. J., Brann, M. R., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: Journal of Biological Chemistry. 275, 38, p. 29547-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations

    Jensen, Anders A., Frølund, Bente, Liljefors, T. & Krogsgaard-Larsen, Povl, 2005, In: Journal of Medicinal Chemistry. 48, 15, p. 4705-45 41 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors

    Jensen, Anders A., Frølund, Bente, Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2003, In: Molecular Pharmacology. 64, 4, p. 865-75 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Acetylcholine

    Jensen, Anders A. & Krogsgaard-Larsen, Povl, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 263-281

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

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