Povl Krogsgaard-Larsen
Professor, emeritus
Medicinal Chemistry
Jagtvej 162
2100 København Ø
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(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors
Ahmadian, H., Nielsen, Birgitte, Bräuner, Hans, Johansen, Tommy Nørskov, Stensbøl, T. B., Sløk, F. A., Sekiyama, N., Nakanishi, S., Krogsgaard-Larsen, Povl & Madsen, Ulf, 24 Oct 1997, In: Journal of Medicinal Chemistry. 40, 22, p. 3700-5Research output: Contribution to journal › Journal article › Research › peer-review
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Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity
Bolvig, T., Larsson, O. M., Pickering, Darryl S, Nelson, N., Falch, E., Krogsgaard-Larsen, Povl, Schousboe, Arne & Pickering, Darryl S, 1999, In: European Journal of Pharmacology. 375, 1-3, p. 367-74 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABA(A) receptors
Brehm, L., Ebert, B., Kristiansen, Uffe, Wafford, K. A., Kemp, J. A. & Krogsgaard-Larsen, Povl, 1997, In: European Journal of Medicinal Chemistry. 32, 4, p. 357-363 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology
Brehm, L., Greenwood, J. R., Hansen, K. B., Nielsen, Birgitte, Egebjerg, J., Stensbøl, T. B., Bräuner, Hans, Sløk, F. A., Kronborg, T. T. A. & Krogsgaard-Larsen, Povl, 10 Apr 2003, In: Journal of Medicinal Chemistry. 46, 8, p. 1350-8Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structure and Quantum Chemical Ab Initio Calculations of Ibotenic Acid, an Excitatory Amino Acid Receptor Agonist
Brehm, L., Frydenvang, Karla Andrea, Krogsgaard-Larsen, Povl & Liljefors, T., 1998, In: Structural Chemistry. 9, 2, p. 149-155 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and stereochemical requirements for interactions with subtypes of central excitatory amino acid receptors
Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B., Madsen, Ulf, Jørgensen, Flemming Steen, Hansen, J. J. & Krogsgaard-Larsen, Povl, 1990, Frontiers in Drug Research; Alfred Benzon Symposium 28. Jensen, B., Jørgensen, F. S. & Kofod, H. (eds.). Copenhagen: Munksgaard , p. 92-105 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA
Brehm, L., Greenwood, J. R., Sløk, F. A., Holm, M. M., Nielsen, Birgitte, Geneser, U., Stensbøl, T. B., Bräuner, Hans, Begtrup, M., Egebjerg, J. & Krogsgaard-Larsen, Povl, Aug 2004, In: Chirality. 16, 7, p. 452-66Research output: Contribution to journal › Journal article › Research › peer-review
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Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors
Brier, T. J., Mellor, I. R., Tikhonov, D. B., Neagoe, I., Shao, Z., Brierley, M. J., Strømgaard, Kristian, Jaroszewski, J. W., Krogsgaard-Larsen, Povl & Usherwood, P. N. R., Oct 2003, In: Molecular Pharmacology. 64, 4, p. 954-964 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., O'Hara, P. & Krogsgaard-Larsen, Povl, 1999, In: Journal of Biological Chemistry. 274, 26, p. 18382-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D
Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., Larsen, Birger Brodin, Krogsgaard-Larsen, Povl & O'Hara, P., 2001, In: BBA General Subjects. 1518, 3, p. 237-48 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor
Bräuner, Hans, Jensen, Anders A. & Krogsgaard-Larsen, Povl, 1999, In: NeuroReport. 10, 18, p. 3923-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ligands for glutamate receptors: design and therapeutic prospects
Bräuner, Hans, Egebjerg, J., Nielsen, E. O., Madsen, Ulf & Krogsgaard-Larsen, Povl, 13 Jul 2000, In: Journal of Medicinal Chemistry. 43, 14, p. 2609-45Research output: Contribution to journal › Journal article › Research › peer-review
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A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2
Bräuner, Hans, Hermit, M. B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl & Johansen, Tommy Nørskov, 6 Oct 2000, In: European Journal of Pharmacology. 406, 1, p. 41-4Research output: Contribution to journal › Journal article › Research › peer-review
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Functional partial agonism at cloned human muscarinic acetylcholine receptors
Bräuner, Hans, Ebert, B., Brann, M. R., Falch, E. & Krogsgaard-Larsen, Povl, 10 Oct 1996, In: European Journal of Pharmacology. 313, 1-2, p. 145-50Research output: Contribution to journal › Journal article › Research › peer-review
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Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors
Bräuner, Hans, Ebert, B., Brann, M. R., Falch, E. & Krogsgaard-Larsen, Povl, 9 Jun 1995, In: Journal of Medicinal Chemistry. 38, 12, p. 2188-95Research output: Contribution to journal › Journal article › Research › peer-review
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A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid
Bräuner, Hans, Sløk, F. A., Skjaerbaek, N., Ebert, B., Sekiyama, N., Nakanishi, S. & Krogsgaard-Larsen, Povl, 2 Aug 1996, In: Journal of Medicinal Chemistry. 39, 16, p. 3188-94Research output: Contribution to journal › Journal article › Research › peer-review
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Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain
Bräuner, Hans & Krogsgaard-Larsen, Povl, 15 Apr 2000, In: Genomics. 65, 2, p. 121-8Research output: Contribution to journal › Journal article › Research › peer-review
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Functional pharmacology of cloned heterodimeric GABA-B receptors expressed in mammalian cells
Bräuner, Hans & Krogsgaard-Larsen, Povl, Dec 1999, In: British Journal of Pharmacology. 128, 7, p. 1370-4Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors
Bräuner, Hans, Nielsen, Birgitte, Stensbøl, T. B., Johansen, Tommy Nørskov, Skjaerbaek, N. & Krogsgaard-Larsen, Povl, 24 Sep 1997, In: European Journal of Pharmacology. 335, 2-3, p. R1-3Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors
Bräuner, Hans, Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 5 Jun 1998, In: European Journal of Pharmacology. 350, 2-3, p. 311-6Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors
Bräuner, Hans & Krogsgaard-Larsen, Povl, Jan 1998, In: British Journal of Pharmacology. 123, 2, p. 269-74Research output: Contribution to journal › Journal article › Research › peer-review
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Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol
Bunch, Lennart, Norrby, P., Frydenvang, Karla Andrea, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2001, In: Organic Letters. 3, 3, p. 433-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and receptor binding affinity of new selective GluR5 ligands
Bunch, Lennart, Johansen, T. H., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl & Madsen, Ulf, Apr 2001, In: Bioorganic & Medicinal Chemistry. 9, 4, p. 875-9Research output: Contribution to journal › Journal article › Research › peer-review
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Subtype selective kainic acid receptor agonists: discovery and approaches to rational design
Bunch, Lennart & Krogsgaard-Larsen, Povl, 2009, In: Medicinal Research Reviews. 29, 1, p. 3-28Research output: Contribution to journal › Review › Research › peer-review
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Mixed cyano-gilman cuprates - Advances in conjugate addition to alpha,beta-unsaturated pyroglutaminol
Bunch, Lennart, Krogsgaard-Larsen, Povl & Madsen, Ulf, Jan 2002, In: Synthesis. 1, p. 31-33Research output: Contribution to journal › Journal article › Research › peer-review
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Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: Application to the synthesis of thioibotenic acid
Bunch, Lennart, Krogsgaard-Larsen, Povl & Madsen, Ulf, 5 Apr 2002, In: Journal of Organic Chemistry. 67, 7, p. 2375-2377Research output: Contribution to journal › Journal article › Research › peer-review
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Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue
Bunch, Lennart, Liljefors, T., Greenwood, J. R., Frydenvang, Karla Andrea, Bräuner, Hans, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2003, In: Journal of Organic Chemistry. 68, 4, p. 1489-95 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational analysis and molecular modelling of a partial GABA(A) agonist and a glycine antagonist related to the GABA(A) agonist, THIP
Byberg Buur, J. R., Hjeds, H., Krogsgaard-Larsen, Povl & Jørgensen, Flemming Steen, 1 Dec 1993, In: Drug Design and Discovery. 10, 3, p. 213-229 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory amino acid agonists and partial agonists
Christensen, I. T., Reinhardt, A., Nielsen, B., Ebert, B., Madsen, Ulf, Nielsen, E. O., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: Drug Design and Delivery. 5, 1, p. 57-71 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid
Christensen, I. T., Ebert, B., Madsen, Ulf, Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 18 Sep 1992, In: Journal of Medicinal Chemistry. 35, 19, p. 3512-3519 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory Amino acid agonists and parital agonists
Christensen, I. T., Reinhardt, A., Nielsen, Birgitte, Ebert, B., Madsen, Ulf, Nielsen, E. Ø., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: drug design and delivery. 5, p. 57-71 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preparations of deuterium labelled guvacine and isoguvacine
Christensen, Søren Brøgger & Krogsgaard-Larsen, Povl, 1 Jan 1980, In: Journal of Labelled Compounds and Radiopharmaceuticals. 17, 2, p. 191-202 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid
Clausen, Rasmus Prætorius, Bräuner, Hans, Greenwood, J. R., Hermit, M. B., Stensbøl, T. B., Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 12 Sep 2002, In: Journal of Medicinal Chemistry. 45, 19, p. 4240-5Research output: Contribution to journal › Journal article › Research › peer-review
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Design, synthesis, and characterisation of selective GABA transport inhibitors
Clausen, Rasmus Prætorius, Moltzen, E., Perregaard, J., Lenz, S., Sanchez, S., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O., White, H., Schousboe, Arne & Krogsgaard-Larsen, Povl, Aug 2005, In: Journal of Neurochemistry. 94, p. 150-150Research output: Contribution to journal › Conference abstract in journal › Research
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Structure-Activity Relationship and Pharmacology of γ-Aminobutyric Acid (GABA) Transport Inhibitors
Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 1 Dec 2006, GABA. Enna, S. J. (ed.). p. 265-284 20 p. (Advances in Pharmacology, Vol. 54).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino- 4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues
Clausen, Rasmus Prætorius, Moltzen, E. K., Perregaard, J., Lenz, S., Sanchez, C., Falch, E., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 2005, In: Bioorganic & Medicinal Chemistry. 13, p. 895–908Research output: Contribution to journal › Journal article › Research › peer-review
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Et bud på fremtidens lægemidler mod epilepsi.
Clausen, Rasmus Prætorius, Larsson, O. M., Greenwood, J. & Krogsgaard-Larsen, Povl, 2001, In: Lægemiddelforskning. p. 20-21Research output: Contribution to journal › Journal article › Communication
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Structure–Activity Relationship and Pharmacology of γ‐Aminobutyric Acid Transport Inhibitor
Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, GABA. Enna, S. (ed.). Vol. 54. p. 265–284 (Advances in Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization
Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and pharmacology of 2-amino-4-(4-hydroxy-1,2,5-thiadiazol-3-yl)butyric acid.
Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, Aug 2001, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 222, p. U660-U660Research output: Contribution to journal › Conference article › Research
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Analogues of the low-efficacy partial GABAA agonist 4-PIOL. Syntheses and in vitro pharmacological studies
De Amici, M., Frølund, Bente, Hjeds, H. & Krogsgaard-Larsen, Povl, Sep 1991, In: European Journal of Medicinal Chemistry. 26, 6, p. 625-631 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analogues of the Low-efficacy Partial GABA-A Agonist 4-PIOL. Synthesis and in vitro Pharmacological Studies
De Amici, M., Frølund, Bente, Hjeds, H. & Krogsgaard-Larsen, Povl, 1991, In: European Journal of Medicinal Chemistry. 26, p. 625–631Research output: Contribution to journal › Journal article › Research › peer-review
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Subtype-selective excitatory amino acid receptor agonists and antagonists derived from ibotenic acid
Ebert, B., Lund, Trine Meldgaard, Madsen, Ulf, Brehm, L. & Krogsgaard-Larsen, Povl, 1992, New leads and targets in drug research: Alfred Benzon Symposium 33. Krogsgaard-Larsen, P., Christensen, S. B. & Kofod, H. (eds.). Copenhagen, p. 340-351 11 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA
Ebert, B., Madsen, Ulf, Lund, Trine Meldgaard, Lenz, S. M. & Krogsgaard-Larsen, Povl, Jun 1994, In: Neurochemistry International. 24, 6, p. 507-15 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular pharmacology of cortical and spinal AMPA receptors
Ebert, B., Madsen, Ulf, Lund, Trine Meldgaard, Holm, T. & Krogsgaard-Larsen, Povl, 1 Jan 1992, In: Molecular Neuropharmacology. 2, 1, p. 47-49 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Equilibrium binding characteristics of [3H]thiomuscimol
Ebert, B., Frølund, Bente, Diemer, N. & Krogsgaard-Larsen, Povl, 1999, In: Neurochemistry International. 34, p. 427–434Research output: Contribution to journal › Journal article › Research › peer-review
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Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and Analogues
Falch, E., Frølund, Bente, Perregaard, Sanchez, C., Søkilde, B., Buur, A., Hansen, A., Frydenvang, Karla Andrea, Brehm, L., Bolvig, T., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 1999, In: Journal of Medicinal Chemistry. 42, p. 5402–5414Research output: Contribution to journal › Journal article › Research › peer-review
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Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships
Falch, E., Brehm, L., Mikkelsen, I., Johansen, Tommy Nørskov, Skjærbæk, N., Nielsen, Birgitte, Stensbøl, T. B., Ebert, B. & Krogsgaard-Larsen, Povl, 1998, In: Journal of Medicinal Chemistry. 41, p. 2513-2523 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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(-)-(R)-5,5-dimethylmorpholinyl-2-acetic acid ethyl ester hydrochloride, C10H20NO3+.Cl-
Frydenvang, Karla Andrea, Enna, S. J. & Krogsgaard-Larsen, Povl, 15 Aug 1997, In: Acta Crystallographica Section C: Crystal Structure Communications. 53, 8, p. 1088-1091 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural characteristics of isoxazol-3-ol and isothiazol-3-ol, carboxy group bioisosteres examined by X-ray crystallography and ab initio calculations
Frydenvang, Karla Andrea, Matzen, L., Norrby, P. O., Sløk, F. A., Liljefors, T., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Sep 1997, In: Journal of the Chemical Society. Perkin Transactions 2. 9, p. 1783-1791 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1303013