Povl Krogsgaard-Larsen

Povl Krogsgaard-Larsen

Professor, emeritus


Publication year:
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1 - 100 out of 194Page size: 100
  1. 1973
  2. Published

    Organic hydroxylamine derivatives. VII. Isoxazolin 5 ones. An investigation of a reaction sequence previously stated to give 3 hydroxyisoxazoles

    Krogsgaard-Larsen, Povl, Christensen, Søren Brøgger & Hjeds, H., 1 Jan 1973, In: Acta Chemica Scandinavica. 27, 8, p. 2802-2812 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Organic hydroxylamine derivatives. VIII. Structural analogues of GABA of the isoxazole enol betaine type. Synthesis of 5,6,7,8 tetrahydro 4H isoxazolo[3,4 d]azepin 3 ol zwitterion and some derivatives

    Krogsgaard-Larsen, Povl, Hjeds, H. & Christensen, Søren Brøgger, 1 Jan 1973, In: Acta Chemica Scandinavica. 27, 9, p. 3251-3258 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 1977
  5. Published

    Muscimol analogues. I. Syntheses of 4- and 8-aminocycloheptenol[1,2 d]isoxazol-3-ols and 4-(3-aminopropyl)-5-methyl-3-isoxazolol

    Krogsgaard-Larsen, Povl, Natova, L. & Christensen, Søren Brøgger, 1 Jan 1977, In: ACTA CHEM. SCAND.. B31, 7, p. 577-583 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 1980
  7. Published

    Preparations of deuterium labelled guvacine and isoguvacine

    Christensen, Søren Brøgger & Krogsgaard-Larsen, Povl, 1 Jan 1980, In: Journal of Labelled Compounds and Radiopharmaceuticals. 17, 2, p. 191-202 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. 1987
  9. Published

    Molecular pharmacology of excitatory amino acid receptors: conformational and stereochemical requirements

    Krogsgaard-Larsen, Povl, Madsen, Ulf, Nielsen, Birgitte, Hansen, J. J., Nielsen, E. Ø., Brehm, L. & Curtis, D. R., 1987, Proceedings of the X'th International Congress of Pharmacology. Rand, M. J. & Raper, C. (eds.). Elsevier, p. 113-116 4 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  10. 1989
  11. Published

    Excitatory Amino acid agonists and parital agonists

    Christensen, I. T., Reinhardt, A., Nielsen, Birgitte, Ebert, B., Madsen, Ulf, Nielsen, E. Ø., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: drug design and delivery. 5, p. 57-71 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Excitatory Amino acid agonists: Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid

    Hansen, J. J., Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Brehm, L., Nielsen, E. Ø. & Curtis, D. R., 1989, In: Journal of Medicinal Chemistry. 32, p. 2254-2260 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Excitatory amino acid agonists and partial agonists

    Christensen, I. T., Reinhardt, A., Nielsen, B., Ebert, B., Madsen, Ulf, Nielsen, E. O., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: Drug Design and Delivery. 5, 1, p. 57-71 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Isoxazole amino acids as glutamic acid receptor agonists: conformational and stereochemical aspects

    Hansen, J. J., Madsen, Ulf, Nielsen, E. Ø., Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 1989, New Methods in Drug Research. Makriayannis, A. (ed.). Barcelona: Prous Scientific Publishers, Vol. 3. p. 73-101 29 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  15. Published

    Medicinal chemical and pharmacological focus on GABA and glutamic acid receptors in neurodegenerative disorders

    Krogsgaard-Larsen, Povl, Hedegaard, A., Nielsen, L., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E., Hjeds, H. & Hansen, J. J., 1989, Trends in Medicinal Chemistry '88. van der Goot, H., Domány, G., Pallos, L. & Timmerman, H. (eds.). Elsevier, Amsterdam, p. 429-452 24 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  16. Published

    Heterocyclic muscarinic agonists: Structural and therapeutic aspects

    Krogsgaard-Larsen, Povl, Jensen, B., Falch, E. & Jørgensen, Flemming Steen, 1 Jan 1989, In: Drugs of the Future. 14, 6, p. 541-561 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 1990
  18. Published

    AMPA receptor agonists, design, synthesis and molecular pharmacology

    Lund, Trine Meldgaard, Christensen, I. T., Madsen, Ulf, Ebert, B., Brehm, L. & Krogsgaard-Larsen, Povl, 1990, In: Neurochemistry International. 16 suppl 1, 51, p. 51 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  19. Published

    Excitatory Amino acid receptor agonists: enantiomeric resolutions by use of enzymes and chiral HPLC

    Hansen, J. J., Nielsen, Birgitte, Reinhardt, A. & Krogsgaard-Larsen, Povl, 1990, In: Acta Pharmaceutica Nordica. 2, p. 185-192 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors

    Madsen, Ulf, Brehm, L., Schaumburg, K., Jørgensen, Flemming Steen & Krogsgaard-Larsen, Povl, 1990, In: Journal of Medicinal Chemistry. 33, 1, p. 374-80 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Structural and stereochemical requirements for interactions with subtypes of central excitatory amino acid receptors

    Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B., Madsen, Ulf, Jørgensen, Flemming Steen, Hansen, J. J. & Krogsgaard-Larsen, Povl, 1990, Frontiers in Drug Research; Alfred Benzon Symposium 28. Jensen, B., Jørgensen, F. S. & Kofod, H. (eds.). Copenhagen: Munksgaard , p. 92-105 14 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  22. Published

    Structural, stereochemical and conformational requirements for activation and blockade of central glutamic acid receptors

    Krogsgaard-Larsen, Povl, Madsen, Ulf, Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B. & Hansen, J. J., 1990, Problems and Wonders of Chirale Molecules. Simonyi, M. (ed.). Budapest: Akadémiai Kiadó, p. 205-225 21 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  23. 1991
  24. Published

    4-PIOL, a low-efficacy partial GABA-A agonist

    Frølund, Bente, Kristiansen, Uffe, Nathan, T., Falch, E., Lambert, J. D. C. & Krogsgaard-Larsen, Povl, 1991, Drug Research related to Neuroactive Amino Acids. Munksgaard

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  25. Published

    Analogues of the Low-efficacy Partial GABA-A Agonist 4-PIOL. Synthesis and in vitro Pharmacological Studies

    De Amici, M., Frølund, Bente, Hjeds, H. & Krogsgaard-Larsen, Povl, 1991, In: European Journal of Medicinal Chemistry. 26, p. 625–631

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Conformational and pharmacological characterization of 4-AHCP, a bicyclic homologue of the excitatory amino acid receptor agonist AMPA

    Lund, Trine Meldgaard, Madsen, Ulf, Ebert, B., Jørgensen, Flemming Steen & Krogsgaard-Larsen, Povl, 1991, In: Med. Chem. Res. 1, p. 136-141 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Excitatory amino acid receptors: multiplicity and structural requirements for activation and blockade

    Krogsgaard-Larsen, Povl, Lund, Trine Meldgaard, Jørgensen, Flemming Steen & Brehn, L., 1991, Excitatory amino acids and synaptic function. Wheal, H. & Thomson, A. (eds.). London: Academic Press, p. 1-17 17 p. (Excitatory Amino Acids and Synaptic Transmission, Academic Press, London).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  28. Published

    Novel (Gamma-Aminobutyric Acid)A Agonists and Partial Agonists

    Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe, Lambert, J. D. C., Falch, E. & Curtis, D. R., 1991, Transmitter Amino Acid Receptors. Barnard, E. A. & Costa, E. (eds.). Raven Press, p. 237–249

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  29. Published

    Analogues of the low-efficacy partial GABAA agonist 4-PIOL. Syntheses and in vitro pharmacological studies

    De Amici, M., Frølund, Bente, Hjeds, H. & Krogsgaard-Larsen, Povl, Sep 1991, In: European Journal of Medicinal Chemistry. 26, 6, p. 625-631 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Electrophysiological studies of the GABAA receptor ligand, 4‐PIOL, on cultured hippocampal neurones

    Kristiansen, Uffe, Lambert, J. D. C., Falch, E. & Krogsgaard-Larsen, Povl, Sep 1991, In: British Journal of Pharmacology. 104, 1, p. 85-90 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 1992
  32. Published

    AMPA receptor agonists: structural, conformational and stereochemical aspects

    Hansen, J., Jørgensen, Flemming Steen, Lund, Trine Meldgaard, Nielsen, Birgitte, Reinhardt, A., Breum, I., Brehm, L. & Krogsgaard-Larsen, Povl, 1992, Excitatory Amino Acid Receptors. Krogsgaard-Larsen, P. & Hansen, J. J. (eds.). Ellis Horwood: Chichester, 30 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  33. Published

    Subtype-selective excitatory amino acid receptor agonists and antagonists derived from ibotenic acid

    Ebert, B., Lund, Trine Meldgaard, Madsen, Ulf, Brehm, L. & Krogsgaard-Larsen, Povl, 1992, New leads and targets in drug research: Alfred Benzon Symposium 33. Krogsgaard-Larsen, P., Christensen, S. B. & Kofod, H. (eds.). Copenhagen, p. 340-351 11 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  34. Published

    Molecular pharmacology of cortical and spinal AMPA receptors

    Ebert, B., Madsen, Ulf, Lund, Trine Meldgaard, Holm, T. & Krogsgaard-Larsen, Povl, 1 Jan 1992, In: Molecular Neuropharmacology. 2, 1, p. 47-49 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships

    Kristiansen, Uffe, bjl587, bjl587, Herdeis, C., Lund, Trine Meldgaard, Nielsen, Birgitte, Hansen, J. J., Falch, E., Hjeds, H. & Krogsgaard-Larsen, Povl, Mar 1992, In: Journal of Neurochemistry. 58, 3, p. 1150-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid

    Christensen, I. T., Ebert, B., Madsen, Ulf, Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 18 Sep 1992, In: Journal of Medicinal Chemistry. 35, 19, p. 3512-3519 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Stereoselective effects of AMOA on non-NMDA receptors expressed in Xenopus oocytes

    Wahl, P., Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Hansen, J. J., Schousboe, Arne & Miledi, R., Nov 1992, In: Journal of Neuroscience Research. 33, 3, p. 392-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 1993
  39. Published

    Design, synthesis and pharmacology of model compounds for indirect elucidation of the topography of AMPA receptor sites

    Madsen, Ulf, Frølund, Bente, Lund, Trine Meldgaard, Ebert, B. & Krogsgaard-Larsen, Povl, 1993, In: European Journal of Medicinal Chemistry. 28, p. 791–800

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Enzymatic resolution of AMPA by use of alpha-chymotrypsin

    Nielsen, Birgitte, Fisker, H., Ebert, B., Madsen, Ulf, Curtis, D. R., Krogsgaard-Larsen, Povl & Hansen, J. J., 1993, In: Bioorganic & Medicinal Chemistry Letters. 3, 1, p. 107–114 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Excitatory amino acid research in Alzheimer´s disease: activation, enhancement and blockade of receptor subtypes

    Krogsgaard-Larsen, Povl, Nielsen, Birgitte & Hansen, J. J., 1993, Advances in Neuropharmacology. Ross, F. C. (ed.). London: Smith-Gordon and Company Limited, p. 241-248 8 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  42. Published

    Conformational analysis and molecular modelling of a partial GABA(A) agonist and a glycine antagonist related to the GABA(A) agonist, THIP

    Byberg Buur, J. R., Hjeds, H., Krogsgaard-Larsen, Povl & Jørgensen, Flemming Steen, 1 Dec 1993, In: Drug Design and Discovery. 10, 3, p. 213-229 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. 1994
  44. Published

    GABAA receptor agonists, partial agonists, and antagonists. Design and therapeutic prospects

    Krogsgaard-Larsen, Povl, Frølund, Bente, Jørgensen, Flemming Steen & Schousboe, Arne, 1994, In: Journal of Medicinal Chemistry. 37, 16, p. 2489-505 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    GABAB antagonists: resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen

    Frydenvang, Karla Andrea, Hansen, J. J., Krogsgaard-Larsen, Povl, Mitrovic, A., Tran, H., Drew, C. A. & Johnston, G. A., 1994, In: Chirality. 6, 7, p. 583-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands

    Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Ebert, B., Krogsgaard-Larsen, Povl & Madsen, Ulf, 1994, In: Journal of Medicinal Chemistry. 37, 20, p. 3252-62 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA

    Ebert, B., Madsen, Ulf, Lund, Trine Meldgaard, Lenz, S. M. & Krogsgaard-Larsen, Povl, Jun 1994, In: Neurochemistry International. 24, 6, p. 507-15 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. 1995
  49. Published

    GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer

    Frydenvang, Karla Andrea, Kristiansen, Uffe, Frølund, Bente, Herdeis, C. & Krogsgaard-Larsen, Povl, 1995, In: Chirality. 7, p. 526–533

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    GABAA Agonists: Resolution and Pharmacology of (+)- and (-)-Isoguvacine Oxide

    Frølund, Bente, Jeppesen, L., Krogsgaard-Larsen, Povl & Hansen, J. J., 1995, In: Chirality. 7, p. 434–438

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    GABAA agonists: Resolution and pharmacology of (+)‐ and (−)‐isoguvacine oxide

    Frølund, Bente, Jeppesen, L., Krogsgaard-Larsen, Povl & Hansen, J. J., 1995, In: Chirality. 7, 6, p. 434-438 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Partial GABAA Receptor agonists. Synthesis and in vitro Pharmacology

    Frølund, Bente, Kristiansen, Uffe, Brehm, L., Hansen, A. B., Krogsgaard-Larsen, Povl & Falch, E., 1995, In: Journal of Medicinal Chemistry. 38, p. 3287–3296

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Synthesis and receptor binding of 5-amino[3H]2methyl-3-isothiazolol ([3H]thiomuscimol), a specific GABAa agonist photoaffinity label

    Frølund, Bente, Ebert, B., Lawrence, L. W., Hurt, S. D. & Krogsgaard-Larsen, Povl, 1995, In: Journal of Labelled Compounds and Radiopharmaceuticals. 36, p. 877–889

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors

    Bräuner, Hans, Ebert, B., Brann, M. R., Falch, E. & Krogsgaard-Larsen, Povl, 9 Jun 1995, In: Journal of Medicinal Chemistry. 38, 12, p. 2188-95

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Partial GABAA Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol

    Frølund, Bente, Kristiansen, Uffe, Brehm, L., Hansen, A. B., Krogsgaard-Larsen, Povl & Falch, E., 1 Aug 1995, In: Journal of Medicinal Chemistry. 38, 17, p. 3287-3296 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. 1996
  57. Published

    GABA-A Receptor Agonists, Partial Agonists and Antagonists

    Frølund, Bente, Krogsgaard-Larsen, Povl & Ebert, B., 1996, The GABA Receptors. 2nd ed. Humana Press

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  58. Published

    N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid

    Madsen, Ulf, Frydenvang, Karla Andrea, Ebert, B., Johansen, Tommy Nørskov, Brehm, L. & Krogsgaard-Larsen, Povl, 1996, In: Journal of Medicinal Chemistry. 39, 1, p. 183-90 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Neuroactive Polyamine Wasp Toxins: Nuclear Magnetic Resonance Spectroscopic Analysis of the Proteolytic Properties of Philantotoxin-343

    Jaroszewski, J., Matzen, L., Frølund, Bente & Krogsgaard-Larsen, Povl, 1996, In: Journal of Medicinal Chemistry. 39, p. 515–521

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Stereospecific GABA-B receptor antagonism

    Frydenvang, Karla Andrea, Frølund, Bente, Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 1996, GABA, receptors, transporters and metabolism. Tanaka, C. & Bowery, N. G. (eds.). Basel: Birkhäuser Verlag

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  61. Published

    Neuroactive polyamine wasp toxins: Nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin-343

    Jaroszewski, J. W., Matzen, L., Frølund, Bente & Krogsgaard-Larsen, Povl, 19 Jan 1996, In: Journal of Medicinal Chemistry. 39, 2, p. 515-521 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid

    Bräuner, Hans, Sløk, F. A., Skjaerbaek, N., Ebert, B., Sekiyama, N., Nakanishi, S. & Krogsgaard-Larsen, Povl, 2 Aug 1996, In: Journal of Medicinal Chemistry. 39, 16, p. 3188-94

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Design of excitatory amino acid receptor agonists, partial agonists and antagonists: Ibotenic acid as a key lead structure

    Krogsgaard-Larsen, Povl, Ebert, B., Lund, Trine Meldgaard, Bräuner, Hans, Sloøk, F. A., Johansen, Tommy Nørskov, Brehm, L. & Madsen, Ulf, 10 Sep 1996, In: European Journal of Medicinal Chemistry. 31, 7-8, p. 515-537 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Functional partial agonism at cloned human muscarinic acetylcholine receptors

    Bräuner, Hans, Ebert, B., Brann, M. R., Falch, E. & Krogsgaard-Larsen, Povl, 10 Oct 1996, In: European Journal of Pharmacology. 313, 1-2, p. 145-50

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. 1997
  66. Published

    AMPA Receptor Agonists. Synthesis, Protolytic Properties and Pharmacology of 3-Isothiazolol Bioisosteres of Glutamic Acid

    Frølund, Bente, Matzen, L., Engesgaard, A., Ebert, B., Didriksen, M., Krogsgaard-Larsen, Povl & Jaroszewski, J., 1997, In: Journal of Medicinal Chemistry. 40, p. 520–527

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Bioisosterically Modified Dipeptide Excitatory Amino Acid Receptor Antagonists Containing 3-Oxygenated Isothiazole Ring Systems

    Matzen, L., Ebert, B., Stensbøl, T. B., Frølund, Bente, Jaroszewski, J. & Krogsgaard-Larsen, Povl, 1997, In: Bioorganic and Medicinal Chemistry. 5, p. 1569–1575

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Excitatory amino acid receptor antagonists: resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA)

    Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Ebert, B., Madsen, Ulf & Krogsgaard-Larsen, Povl, 1997, In: Chirality. 9, 5-6, p. 529-36 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects

    Frølund, Bente, Krogsgaard-Larsen, Povl, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., 1997, In: European Journal of Pharmaceutical Sciences. 4, p. 355–384

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABA(A) receptors

    Brehm, L., Ebert, B., Kristiansen, Uffe, Wafford, K. A., Kemp, J. A. & Krogsgaard-Larsen, Povl, 1997, In: European Journal of Medicinal Chemistry. 32, 4, p. 357-363 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    (-)-(R)-5,5-dimethylmorpholinyl-2-acetic acid ethyl ester hydrochloride, C10H20NO3+.Cl-

    Frydenvang, Karla Andrea, Enna, S. J. & Krogsgaard-Larsen, Povl, 15 Aug 1997, In: Acta Crystallographica Section C: Crystal Structure Communications. 53, 8, p. 1088-1091 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Structural characteristics of isoxazol-3-ol and isothiazol-3-ol, carboxy group bioisosteres examined by X-ray crystallography and ab initio calculations

    Frydenvang, Karla Andrea, Matzen, L., Norrby, P. O., Sløk, F. A., Liljefors, T., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Sep 1997, In: Journal of the Chemical Society. Perkin Transactions 2. 9, p. 1783-1791 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors

    Bräuner, Hans, Nielsen, Birgitte, Stensbøl, T. B., Johansen, Tommy Nørskov, Skjaerbaek, N. & Krogsgaard-Larsen, Povl, 24 Sep 1997, In: European Journal of Pharmacology. 335, 2-3, p. R1-3

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors

    Ahmadian, H., Nielsen, Birgitte, Bräuner, Hans, Johansen, Tommy Nørskov, Stensbøl, T. B., Sløk, F. A., Sekiyama, N., Nakanishi, S., Krogsgaard-Larsen, Povl & Madsen, Ulf, 24 Oct 1997, In: Journal of Medicinal Chemistry. 40, 22, p. 3700-5

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    GABA(A) and GABA(B) receptor agonists, partial agonists, antagonists and modulators: Design and therapeutic prospects

    Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., Nov 1997, In: European Journal of Pharmaceutical Sciences. 5, 6, p. 355-384 30 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. 1998
  77. Published

    Aryl and cycloalkyl analogues of AMPA: synthetic, pharmacological and stereochemical aspects

    Skjærbæk, N., Brehm, L., Johansen, Tommy Nørskov, Hansen, L. M., Nielsen, Birgitte, Ebert, B., Søby, K., Stensbøl, T. B., Falch, E. & Krogsgaard-Larsen, Povl, 1998, In: Bioorganic & Medicinal Chemistry. 6, 1, p. 119-131 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Crystal Structure and Quantum Chemical Ab Initio Calculations of Ibotenic Acid, an Excitatory Amino Acid Receptor Agonist

    Brehm, L., Frydenvang, Karla Andrea, Krogsgaard-Larsen, Povl & Liljefors, T., 1998, In: Structural Chemistry. 9, 2, p. 149-155 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships

    Falch, E., Brehm, L., Mikkelsen, I., Johansen, Tommy Nørskov, Skjærbæk, N., Nielsen, Birgitte, Stensbøl, T. B., Ebert, B. & Krogsgaard-Larsen, Povl, 1998, In: Journal of Medicinal Chemistry. 41, p. 2513-2523 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Inhibitors of γ-aminobutyric acid transport as experimental tools and therapeutic agents

    Krogsgaard-Larsen, Povl, Frølund, Bente & Falch, E., 1998, Methods in enzymology. p. 165–175 (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  81. Published

    Peptide and protein drug delivery : proceedings of a symposium held at the Royal Danish Academy of Sciences and Letters, August 17-21, 1997: Alfred Benzon Symposium, 43

    Frøkjær, Sven, Christrup, Lona Louring, Krogsgaard-Larsen, Povl & Alfred Benzon, F., 1998, Copenhagen: Munksgaard .

    Research output: Book/Report › Book › Research

  82. Published

    Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors

    Bräuner, Hans & Krogsgaard-Larsen, Povl, Jan 1998, In: British Journal of Pharmacology. 123, 2, p. 269-74

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid

    Johansen, Tommy Nørskov, Ebert, B., Bräuner, Hans, Didriksen, M., Christensen, I. T., Søby, K. K., Madsen, Ulf, Krogsgaard-Larsen, Povl & Brehm, L., 12 Mar 1998, In: Journal of Medicinal Chemistry. 41, 6, p. 930-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors

    Bräuner, Hans, Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 5 Jun 1998, In: European Journal of Pharmacology. 350, 2-3, p. 311-6

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. 1999
  86. Published

    Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity

    Bolvig, T., Larsson, O. M., Pickering, Darryl S, Nelson, N., Falch, E., Krogsgaard-Larsen, Povl, Schousboe, Arne & Pickering, Darryl S, 1999, In: European Journal of Pharmacology. 375, 1-3, p. 367-74 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Equilibrium binding characteristics of [3H]thiomuscimol

    Ebert, B., Frølund, Bente, Diemer, N. & Krogsgaard-Larsen, Povl, 1999, In: Neurochemistry International. 34, p. 427–434

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor

    Bräuner, Hans, Jensen, Anders A. & Krogsgaard-Larsen, Povl, 1999, In: NeuroReport. 10, 18, p. 3923-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and Analogues

    Falch, E., Frølund, Bente, Perregaard, Sanchez, C., Søkilde, B., Buur, A., Hansen, A., Frydenvang, Karla Andrea, Brehm, L., Bolvig, T., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 1999, In: Journal of Medicinal Chemistry. 42, p. 5402–5414

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Synthesis and Pharmacology of the Baclofen Homologues. 5-Amino-4-(4-chlorophenyl)pentanoic Acid and the R- and S-Enantiomers of 5-Amino-3-(4-chlorophenyl)pentanoic Acid

    Karla, R., Ebert, B., Thorkildsen, C., Herdeis, C., Johansen, Tommy Nørskov, Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 1999, In: Journal of Medicinal Chemistry. 42, p. 2053-2059 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline

    Pedersen, H., Bräuner, Hans, Ball, R. G., Frydenvang, Karla Andrea, Meier, E., Bøgesø, K. P. & Krogsgaard-Larsen, Povl, 1999, In: Bioorganic & Medicinal Chemistry. 7, 5, p. 795-809 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain

    Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., O'Hara, P. & Krogsgaard-Larsen, Povl, 1999, In: Journal of Biological Chemistry. 274, 26, p. 18382-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    3-pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing

    Zimmermann, D., Janin, Y. L., Brehm, L., Bräuner, Hans, Ebert, B., Johansen, Tommy Nørskov, Madsen, Ulf & Krogsgaard-Larsen, Povl, 1 Nov 1999, In: European Journal of Medicinal Chemistry. 34, 11, p. 967-976

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    Functional pharmacology of cloned heterodimeric GABA-B receptors expressed in mammalian cells

    Bräuner, Hans & Krogsgaard-Larsen, Povl, Dec 1999, In: British Journal of Pharmacology. 128, 7, p. 1370-4

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor

    Strømgaard, Kristian, Brierley, M. J., Andersen, K., Sløk, F. A., Mellor, I. R., Usherwood, P. N., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 16 Dec 1999, In: Journal of Medicinal Chemistry. 42, 25, p. 5224-5234 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. 2000
  97. Published

    A Novel Class of Potent 3-Isoxazolol GABAA Antagonists: Design, Synthesis, and Pharmacology

    Frølund, Bente, Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 2000, In: Journal of Medicinal Chemistry. 43, p. 4930–4933

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor

    Jensen, Anders A., Spalding, T. A., Burstein, E. S., Sheppard, P. O., O'Hara, P. J., Brann, M. R., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: Journal of Biological Chemistry. 275, 38, p. 29547-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects

    Krogsgaard-Larsen, Povl, Frølund, Bente & Frydenvang, Karla Andrea, 2000, In: Current Pharmaceutical Design. 6, 12, p. 1193-209 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist

    Vogensen, S. B., Jensen, H. S., Stensbøl, T. B., Frydenvang, Karla Andrea, Bang-Andersen, B., Johansen, Tommy Nørskov, Egebjerg, J. & Krogsgaard-Larsen, Povl, 2000, In: Chirality. 12, 10, p. 705-13 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  101. Published

    The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity

    Jensen, Anders A., Sheppard, P. O., O'Hara, P. J., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: European Journal of Pharmacology. 397, 2-3, p. 247-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  102. Published

    Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist

    Madsen, Ulf, Sløk, F. A., Stensbøl, T. B., Bräuner, Hans, Lützhøft, H. H., Poulsen, M. V., Eriksen, L. & Krogsgaard-Larsen, Povl, Jan 2000, In: European Journal of Medicinal Chemistry. 35, 1, p. 69-76

    Research output: Contribution to journal › Journal article › Research › peer-review

  103. Published

    Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12

    Strømgaard, Kristian, Bjørnsdottir, I., Andersen, K., Brierley, M. J., Rizoli, S., Eldursi, N., Mellor, I. R., Usherwood, P. N., Hansen, S. H., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Feb 2000, In: Chirality. 12, 2, p. 93-102 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  104. Published

    Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain

    Bräuner, Hans & Krogsgaard-Larsen, Povl, 15 Apr 2000, In: Genomics. 65, 2, p. 121-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  105. Published

    Ligands for glutamate receptors: design and therapeutic prospects

    Bräuner, Hans, Egebjerg, J., Nielsen, E. O., Madsen, Ulf & Krogsgaard-Larsen, Povl, 13 Jul 2000, In: Journal of Medicinal Chemistry. 43, 14, p. 2609-45

    Research output: Contribution to journal › Journal article › Research › peer-review

  106. Published

    A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2

    Bräuner, Hans, Hermit, M. B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl & Johansen, Tommy Nørskov, 6 Oct 2000, In: European Journal of Pharmacology. 406, 1, p. 41-4

    Research output: Contribution to journal › Journal article › Research › peer-review

  107. Published

    Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues

    Strømgaard, Kristian, Brier, T. J., Andersen, K., Mellor, I. R., Saghyan, A., Tikhonov, D., Usherwood, P. N., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 16 Nov 2000, In: Journal of Medicinal Chemistry. 43, 23, p. 4526-4533 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  108. Published

    A novel class of potent 3-isoxazolol GABAA antagonists: Design, systhesis, and pharmacology [3]

    Frølund, Bente, Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 28 Dec 2000, In: Journal of Medicinal Chemistry. 43, 26, p. 4930-4933 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  109. 2001
  110. Published

    A versatile method for solid phase synthesis of polyamines: neuroactive polyamine toxins as example

    Strømgaard, Kristian, Andersen, K., Ruhland, T., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 2001, In: Synthesis. 6, p. 877-884 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  111. Published

    Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D

    Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., Larsen, Birger Brodin, Krogsgaard-Larsen, Povl & O'Hara, P., 2001, In: BBA General Subjects. 1518, 3, p. 237-48 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  112. Published

    Et bud på fremtidens lægemidler mod epilepsi.

    Clausen, Rasmus Prætorius, Larsson, O. M., Greenwood, J. & Krogsgaard-Larsen, Povl, 2001, In: Lægemiddelforskning. p. 20-21

    Research output: Contribution to journal › Journal article › Communication

  113. Published

    Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor

    Jensen, Anders A., Madsen, B. E., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2001, In: European Journal of Pharmacology. 417, 3, p. 177-80 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  114. Published

    Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA

    Johansen, Tommy Nørskov, Stensbøl, T. B., Nielsen, Birgitte, Vogensen, S. B., Frydenvang, Karla Andrea, Sløk, F. A., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2001, In: Chirality. 13, 9, p. 523-32 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  115. Published

    Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist

    Stensbøl, T. B., Jensen, H. S., Nielsen, Birgitte, Johansen, Tommy Nørskov, Egebjerg, J., Frydenvang, Karla Andrea & Krogsgaard-Larsen, Povl, 2001, In: European Journal of Pharmacology. 411, 3, p. 245-53 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  116. Published

    Structural and stereochemical requirements for activation and blocade of excitatory amino acid receptors

    Sløk, F. A., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Ebert, B., Mortensen, M., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E. & Krogsgaard-Larsen, Povl, 2001, Medicinal Chemistry into the Millenium. Campbell, M. M. & Blagbrough, I. S. (eds.). UK: Royal Society of Chemistry, p. 52-64 13 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  117. Published

    Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors

    Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, Hvene, L., Johansen, Tommy Nørskov, Nielsen, Birgitte, Sánchez, C., Stensbøl, T. B., Bischoff, F. & Krogsgaard-Larsen, Povl, 2001, In: Journal of Medicinal Chemistry. 44, 7, p. 1051-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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