Søren Brøgger Christensen

Søren Brøgger Christensen

Professor emeritus, Professor, emeritus

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    ORCID: 0000-0002-5773-6874

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    1. Published

      Prenylated acetophenones from Melicope obscura and Melicope obtusifolia ssp. obtusifolia var. arborea and their distribution in Rutaceae

      Adsersen, A., Smitt, U. W., Simonsen, H. T., Christensen, Søren Brøgger & Jaroszewski, J. W., 2007, In: Biochemical Systematics and Ecology. 35, 7, p. 447-453

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response

      Ali, H., Christensen, Søren Brøgger, Foreman, J. C., Pearce, F. L., Piotrowski, W. & Thastrup, Ole, 1985, In: British Journal of Pharmacology. 85, 3, p. 705-12 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN

      Andersen, A., Cornett, Claus, Lauridsen, A., Olsen, C. E. & Christensen, Søren Brøgger, 1994, In: Acta Chemica Scandinavica. Supplementum. 48, 4, p. 340-346 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      CA2+-ATPASE INHIBITORY ACTIVITY OF A LOCKED ANALOG OF THAPSIGARGIN

      Andersen, A., Treiman, M., Poulsen, J. C. J., Cornett, Claus, Moldt, P., Olsen, C. E. & Christensen, Søren Brøgger, 1994, In: Bioorganic & Medicinal Chemistry Letters. 4, 5, p. 657-660 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Localization and in-vivo characterization of Thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

      Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, Kirsten, Andersen-Ranberg, Johan, Nyberg, N., Christensen, Søren Brøgger & Simonsen, H. T., 2017, In: Plant Physiology. 174, 1, p. 56-72 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

      Andersen, T. B., Rasmussen, S. A., Christensen, Søren Brøgger & Simonsen, H. T., Jan 2019, In: Phytochemistry. 157, https://doi.org/10.1016/j.phytochem.2018.10.027, p. 168-174 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Isorhamnetin3-(2,6-dirhamnosylgalactoside)-7-rhamnoside and 3-(6-rhamnosylgalactoside)-7-rhamnoside from Rhazya stricta

      Andersen, W. K., Omar, A. A. & Christensen, Søren Brøgger, 23 Dec 1986, In: Phytochemistry. 26, 1, p. 291-294 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Localization of the acyl groups in proazulene guaianolides from Thapsia transtagana and Thapsia garganica

      Avato, P., Cornett, Claus, Andersen, A., Smitt, U. W. & Christensen, Søren Brøgger, 1993, In: Journal of Natural Products. 56, 3, p. 411-415 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

      Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Amaryllidaceae alkaloids from Rauhia multiflora (Kunth) Ravenna

      Birkholm, T., Rasmussen, N., Christensen, Søren Brøgger, Jäger, A. & Rønsted, Nina, Aug 2011, In: Planta Medica. 77, 12, PG12.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    11. Published

      Structural elucidation and partial synthesis of 3-hydroxyheterodendrin, a cyanogenic glucoside from Acacia sieberiana var. woodii

      Brimer, L., Christensen, Søren Brøgger, Jaroszewski, J. W. & Nartey, F., 1981, In: Phytochemistry. 20, 9, p. 2221-2223 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      2-β-d-Glucopyranosyloxy-2-methylpropanol in Acacia sieberana var. woodii

      Brimer, L., Christensen, Søren Brøgger & Nartey, F., 1982, In: Phytochemistry. 21, 8, p. 2005-2007 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Ancistrocladinium A and B, the first N,C-coupled naphthyldihydroisoquinoline alkaloids, from a Congolese Ancistrocladus species

      Bringmann, G., Kajahn, I., Reichert, M., Pedersen, S. E. H., Faber, J. H., Gulder, T., Brun, R., Christensen, Søren Brøgger, Ponte-Sucre, A., Moll, H., Heubl, G. & Mudogo, V., 8 Dec 2006, In: Journal of Organic Chemistry. 71, 25, p. 9348-9356 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Ancistrotanzanine C and related 5,1’- and 7,3’- coupled naphtylisoquinoline alkaloids from Ancistrocladus tanzaniensis

      Bringmann, G., Dreyer, M., Faber, J. H., Dalsgaard, P. W., Stærk, Dan, Jaroszewski, J. W., Ndangalasi, H., Mbago, F., Brun, R. & Christensen, Søren Brøgger, 2004, In: Journal of Natural Products. 67, p. 743-748

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Ancistrotanzanine A, the first 5,3’-coupled naphtylisoquinoline alkaloid, and two further, 5,8’-linked related compounds from the newly described species Ancistrocladus tanzaniensis

      Bringmann, G., Dreyer, M., Faber, J. H., Dalsgaard, P. W., Stærk, Dan, Jaroszewski, J. W., Ndangalasi, H., Mbago, F., Brun, R., Reichert, M., Maksimenka, K. & Christensen, Søren Brøgger, 2003, In: Journal of Natural Products. 66, p. 1159-1165

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Incorporation of the crossfire Beilstein database into the organic chemistry curriculum at the Royal Danish School of Pharmacy

      Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 1 Jun 2002, In: Journal of Chemical Education. 79, 6, 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Structure of histamine releasing guaianolides from Thapsia species

      Christensen, Søren Brøgger, Norup, E., Rasmussen, U. & Øgaard Madsen, J., 1984, In: Phytochemistry. 23, 8, p. 1659-1663 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo

      Chen, M., Christensen, Søren Brøgger, Zhai, L., Rasmussen, M. H., Theander, Thor Grundtvig, Frøkjær, Sven, Steffansen, B., Davidsen, J. & Kharazmi, A., 1997, In: Journal of Infectious Diseases. 176, 5, p. 1327-33 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection

      Chen, M., Theander, Thor Grundtvig, Christensen, Søren Brøgger, Hviid, Lars, Zhai, L. & Kharazmi, A., 1994, In: Antimicrobial Agents and Chemotherapy. 38, 7, p. 1470-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani

      Chen, M., Christensen, Søren Brøgger, Theander, Thor Grundtvig & Kharazmi, A., 1994, In: Antimicrobial Agents and Chemotherapy. 38, 6, p. 1339-44 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones

      Chen, M., Zhai, L., Christensen, Søren Brøgger, Theander, Thor Grundtvig & Kharazmi, A., 2001, In: Antimicrobial Agents and Chemotherapy. 45, 7, p. 2023-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania

      Chen, M., Christensen, Søren Brøgger, Blom, J., Lemmich, E., Nadelmann, L., Fich, K., Theander, Thor Grundtvig & Kharazmi, A., 1993, In: Antimicrobial Agents and Chemotherapy. 37, 12, p. 2550-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      An antileishmanial chalcone from Chinese licorice roots

      Christensen, Søren Brøgger, Ming, C., Andersen, L., Hjørne, U., Olsen, C. E., Cornett, Claus, Theander, Thor Grundtvig & Kharazmi, A., 1994, In: Planta Medica. 60, 2, p. 121-3 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Sesquiterpenoids from Thapsia species and medicinal chemistry of the thapsigargins.

      Christensen, Søren Brøgger, Andersen, A. & Smitt, U. W., 1997, In: Fortschritte der Chemie organischer Naturstoffe. Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles. 71, p. 129-167 39 p.

      Research output: Contribution to journal › Review › Research › peer-review

    25. Published

      Thapsigargin, constitution of a sesquiterpene lactone histamine liberator from thapsia garganica

      Christensen, Søren Brøgger, Rasmussen, U. & Christophersen, C., 1980, In: Tetrahedron Letters. 21, 39, p. 3829-3830 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Drugs for the neglected disease malaria based on natural products

      Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 1 Jan 2011, Bioactive Compounds from Natural Sources: Natural Products as Lead Compounds in Drug Discovery, Second Edition. CRC Press, p. 525-550 26 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    27. Published

      1-β-vicianosyl-(S)-2-methylbutyrate, a 1-O-acylglycoside from Acacia sieberana var. Woodii

      Christensen, Søren Brøgger, Brimer, L. & Nartey, F., 1982, In: Phytochemistry. 21, 11, p. 2683-2685 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Atriplex nummularia, a source for the two molluscicide saponins: Hederagenin-3-O-β-D-glucuronopyranoside and calenduloside E

      Christensen, Søren Brøgger & Omar, A. A., 1 Dec 1985, In: Journal of Natural Products. 48, 1, 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Absolute configurations of the histamine liberating sesquiterpene lactones thapsigargin and trilobolide

      Christensen, Søren Brøgger & Norup, E., 1985, In: Tetrahedron Letters. 26, 1, p. 107-110 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Ca2+-ATPase inhibitory activity of a locked analogue of thapsigargin

      Christensen, Søren Brøgger, Olsen, C. E., Moldt, P., Cornett, Claus, Poulsen, J. J., Treiman, M. & Andersen, A., 1994, In: Bioorganic & Medicinal Chemistry Letters.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Neglected diseases

      Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 347-368 22 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    32. Published

      Drugs for the neglected disease malaria based on natural products

      Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2012, Bioactive compounds from natural sources: natural products as lead compounds in drug discovery. Tringali, C. (ed.). 2 ed. Boca Raton: CRC Press, p. 525-550

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    33. Published

      Targeting thapsigargin towards tumors

      Christensen, Søren Brøgger, Doan, T. Q. N., Paulsen, E. S., Sehgal, P., Møller, J. V., Nissen, P., Denmeade, S. R., Isaacs, J. T. & Dionne, C. A., 2015, In: Steroids. 97, p. 2-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Drugs and drug leads based on natural products for treatment and prophylaxis of malaria

      Christensen, Søren Brøgger, 25 Feb 2015, Evidence-based validation of herbal medicine: Elsevier. Amsterdam, p. 307-319

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    35. Published

      The pharmacophore of thapsigargin

      Christensen, Søren Brøgger, Skytte, D. M., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M. & Møller, J. V., Aug 2010, In: Planta Medica. 76, 12, p. 1187

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    36. Published

      Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium

      Christensen, Søren Brøgger, Dubois, C., Abeele, F. V., Sehgal, P., Olesen, C., Junker, S., Prevarskaya, N. & Møller, J. V., 2013, In: F E B S Journal. 280, 21, p. 5430-5440 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Natural Products that Changed Society

      Christensen, Søren Brøgger, 2021, In: Biomedicines. 9, 5, 31 p., 472.

      Research output: Contribution to journal › Review › Research › peer-review

    38. Published

      Derivatives of thapsigargin as probes of its binding site on endoplasmic reticulum Ca2+ ATPase. Stereoselectivity and important functional groups

      Christensen, Søren Brøgger, Andersen, A., Poulsen, J. C. J. & Treiman, M., 13 Dec 1993, In: FEBS Letters. 335, 3, p. 345-348 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Toxicodynamics of tumour promoters of mouse skin III. Specific binding of the tumour promoter thapsigargin as measured by the cold-acetone filter assay

      Christensen, Søren Brøgger, Hergenhahn, M., Roeser, H. & Hecker, E., 1 May 1992, In: Journal of Cancer Research and Clinical Oncology. 118, 5, p. 344-348 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development

      Christensen, Søren Brøgger, Simonsen, H. T., Engedal, N., Nissen, P., Møller, J. V., Denmeade, S. R. & Isaacs, J. T., 2021, In: Progress in the chemistry of organic natural products. 115, p. 59-114

      Research output: Contribution to journal › Review › Research › peer-review

    41. Published

      Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams

      Christensen, Søren Brøgger, 2021, In: Molecules. 26, 19, 31 p., 6057.

      Research output: Contribution to journal › Review › Research › peer-review

    42. Published

      Validation of anti-malarial leads from natural products and traditional medicine for treatment of malaria

      Christensen, Søren Brøgger, 2022, In Evidence-Based validation of herbal medicine. Mukherjee, P. K. (ed.). 2 ed. Amsterdam: Elsevier, p. 389-407

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    43. Published

      Incorporation of the Cross Fire Beilstein database in the organic chemistry curriculum at the Royal Danish School of Pharmacy

      Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 2002, In: Journal of Chemical Education. 79, p. 765-768

      Research output: Contribution to journal › Journal article › Research

    44. Published

      A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells

      Christensen, Søren Brøgger, Skytte, D. M., Denmeade, S. R., Dionne, C., Møller, J. V., Nissen, P. & Isaacs, J. T., 2009, In: Anti-Cancer Agents in Medicinal Chemistry. 9, 3, p. 276-294

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Neglected diseases

      Christensen, Søren Brøgger, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 341-358

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

    46. Published

      Preparations of deuterium labelled guvacine and isoguvacine

      Christensen, Søren Brøgger & Krogsgaard-Larsen, Povl, 1 Jan 1980, In: Journal of Labelled Compounds and Radiopharmaceuticals. 17, 2, p. 191-202 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides

      Christensen, Søren Brøgger, 2022, In: Molecules. 27, 17, 29 p., 5648.

      Research output: Contribution to journal › Review › Research › peer-review

    48. Published

      Concise Synthesis of Thapsigargin from Nortrilobolide

      Crestey, F., Toma, M. & Christensen, Søren Brøgger, 8 Sep 2015, In: Tetrahedron Letters. 56, 43, p. 5896-5898 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life

      Dao, T. T., Sehgal, P., Thanh Tung, T., Møller, J. V., Nielsen, J., Palmgren, Michael, Christensen, Søren Brøgger & Fuglsang, Anja Thoe, 2016, In: P L o S One. 11, 9, 19 p., e0163260.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy (Science Translational Medicine)

      Denmeade, S. R., Mhaka, A. M., Rosen, D. M., Brennen, W. N., Dalrymple, S., Dach, I., Olesen, C., Gurel, B., DeMarzo, A. M., Wilding, G., Carducci, M. A., Dionne, C. A., Møller, J. V., Nissen, Poul, Christensen, Søren Brøgger & Isaacs, J. T., 18 Jul 2012, In: Science Translational Medicine. 4, 143, 143er4.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

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    ID: 1300951