Søren Brøgger Christensen

Søren Brøgger Christensen

Professor emeritus, Professor, emeritus

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    ORCID: 0000-0002-5773-6874

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    1. Published

      Accelerating the domestication of new crops: feasibility and approaches

      Østerberg, J. T., Xiang, Wen, Olsen, L. I., Edenbrandt, A. K., Vedel, S. E., Christiansen, Andreas, Landes, X., Andersen, M. M., Pagh-Rasmussen, Peter, Sandøe, Peter, Nielsen, J., Christensen, Søren Brøgger, Thorsen, Bo Jellesmark, Kappel, Klemens, Gamborg, Christian & Palmgren, Michael, 2017, In: Trends in Plant Science. 22, 5, p. 373-384 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Psychotropic constituents of Mentha aquatica L.

      van Staden, J., Stafford, G. I., Almqvist, J. P., Vangsøe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A. & Jäger, A. K., 2007.

      Research output: Contribution to conference › Poster › Research

    3. Published

      Phorbol Rearrangements

      Zimmermann, T., Franzyk, Henrik & Christensen, Søren Brøgger, 28 Sep 2018, In: Journal of Natural Products. 81, 9, p. 2134-2137 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

      Zimmermann, T., Christensen, Søren Brøgger & Franzyk, Henrik, 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-O-(12-Aminododecanoyl)- 8-O-Debutanoylthapsigargin

      Zimmermann, T., Drasar, P., Rempelova, S., Christensen, Søren Brøgger, Khripach, V. & Jurasek, M., 2020, In: Biomolecules. 10, 11 p., 1640.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed

      Ziegler, H. L., Hansen, Harald S., Stærk, Dan, Christensen, Søren Brøgger, Hägerstrand, H. & Jaroszewski, J. W., 2004, In: Antimicrobial Agents and Chemotherapy. 48, p. 4067-4071

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria

      Zhai, L., Blom, J., Chen, M., Christensen, Søren Brøgger & Kharazmi, A., 1995, In: Antimicrobial Agents and Chemotherapy. 39, 12, p. 2742-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      The antileishmanial activity of novel oxygenated chalcones and their mechanism of action

      Zhai, L., Chen, M., Blom, J., Theander, Thor Grundtvig, Christensen, Søren Brøgger & Kharazmi, A., 1999, In: Journal of Antimicrobial Chemotherapy. 43, 6, p. 793-803 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs

      Winther, A. L., Liu, Huizhen, Sonntag, Y., Olesen, C., le Maire, M., Søhoel, H., Olsen, C. E., Christensen, Søren Brøgger, Nissen, P. & Møller, J. V., 2010, In: Journal of Biological Chemistry. 285, 37, p. 28883-28892

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain

      Verma, A., Hirsch, D. J., Hanley, M. R., Thastrup, O., Christensen, Søren Brøgger & Snyder, S. H., 1990, In: Biochemical and Biophysical Research Communications. 172, 2, p. 811-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Thapsigargin affinity purification of intracellular P2A-type Ca2+ ATPases

      Vandecaetsbeek, I., Christensen, Søren Brøgger, Liu, Huizhen, van Veldhoven, P. P., Waelkens, E., Eggermont, J., Raeymaekers, L., Møller, J. V., Nissen, P., Wuytack, F. & Vangheluwe, P., 1 May 2011, In: BBA General Subjects. 1813, 5, p. 1118-1127

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Psychotropic constituents of Mentha aquatica L.

      Van Staden, J., Stafford, G. ,. I., Almqvist, J. P., Vangsoe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A. & Jäger, A., Aug 2007, In: Planta Medica. 73, 9, p. 928-929

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Cover Feature: LEGO-Inspired Drug Design: Unveiling a Class of Benzo[d ]thiazoles Containing a 3,4-Dihydroxyphenyl Moiety as Plasma Membrane H+ -ATPase Inhibitors (ChemMedChem 1/2018)

      Tung, T., Dao, T. T., Junyent, M. G., Palmgren, Michael, Pomorski, Thomas Guenther, Fuglsang, Anja Thoe, Christensen, Søren Brøgger & Nielsen, J., 8 Jan 2018, In: ChemMedChem. 13, 1, 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      LEGO-inspired drug design: Discovery of novel fungal Plasma membrane H+-ATPase (Pma1) inhibitors from small molecule libraries: An introduction of HFSA-SBS_DOS-RD strategy in drug discovery.

      Tung, T. T., Dao, T. T., Palmgren, M. B., Fuglsang, A. T., Christensen, Søren Brøgger & Nielsen, J., 2 Apr 2017.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    15. Published

      A tool coming of age: Thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases

      Treiman, M., Caspersen, C. & Christensen, Søren Brøgger, 1 Jan 1998, In: Trends in Pharmacological Sciences. 19, 4, p. 131-135 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      19a-hydroxy-3-oxo-ursa-1,12-dien-28-oic acid, an antiplasmodial triterpenoid isolated from Canthium multiflorum

      Traore, M., Ziegler, H. L., Olsen, C. E., Hassanata, M., Pierre, G. I., Nacoulma, O. G., Guiguemdé, T. R. & Christensen, Søren Brøgger, 2009, In: Natural Product Research. 23, 12, p. 1108-1111 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      A new oxygenated ursane derivative from Canthium multiflorum

      Traore, M., Jaroszewski, J. W., Olsen, C. E., Ouédraogo, J. B., Pierre, G. I., Nacoulma, O. G., Guiguemdé, T. R. & Christensen, Søren Brøgger, 2008, In: Planta Medica. 74, 5, p. 560-562 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Cytotoxic kurubasch aldehyde from Trichilia emetica

      Traore, M., Zhai, L., Chen, M., Olsen, C. E., Odile, N., Pierres, G. I., Bosco, O. J., Robert, G. T. & Christensen, Søren Brøgger, 2007, In: Natural Product Reports. 21, 1, p. 13-17

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Molluscicidal saponins from a Zimbabwean strain of Phytolacca dodecandra

      Thiilborg, S. T., Christensen, Søren Brøgger, Cornett, Claus, Olsen, C. E. & Lemmich, E., 1994, In: Phytochemistry. 36, 3, p. 753-759 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Molluscicidal saponins from Phytolacca dodecandra

      Thiilborg, S. T., Christensen, Søren Brøgger, Cornett, Claus, Olsen, C. E. & Lemmich, E., 1993, In: Phytochemistry. 32, 5, p. 1167-1171 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Thapsigargin: a novel molecular probe for studying intracellular calcium release and storage

      Thastrup, Ole, Dawson, A. P., Scharff, O., Foder, B., Cullen, P. J., Drøbak, B. K., Bjerrum, P. J., Christensen, Søren Brøgger & Hanley, M. R., 1994, In: Agents and Actions. 43, 3-4, p. 187-93 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations

      Thastrup, Ole, Linnebjerg, H., Bjerrum, P. J., Knudsen, J. B. & Christensen, Søren Brøgger, 1987, In: BBA General Subjects. 927, 1, p. 65-73 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Cover picture: Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds

      Thanh Tung, T., Christensen, Søren Brøgger & Nielsen, J., 25 Oct 2017, In: Chemistry - A European Journal. 2 p.

      Research output: Contribution to journal › Journal article › Communication

    24. Published

      LEGO-inspired drug design: unveiling a class of Benzo[d]thiazoles containing a 3,4-Dihydroxyphenyl moiety as plasma membrane H+-ATPase inhibitors

      Thanh Tung, T., Dao, T. T., Grifell Junyent, M., Palmgren, Michael, Pomorski, Thomas Guenther, Fuglsang, Anja Thoe, Christensen, Søren Brøgger & Nielsen, J., 2018, In: ChemMedChem. 13, 1, 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors

      Thanh Tung, T., Jakobsen, Tim Holm, Dao, T. T., Fuglsang, Anja Thoe, Givskov, Michael, Christensen, Søren Brøgger & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds

      Thanh Tung, T., Christensen, Søren Brøgger & Nielsen, J., 11 Oct 2017, In: Chemistry: A European Journal. 23, p. 18125-18128

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

      Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M. H., Yli-Kauhaluoma, J., Talman, V., Franzyk, Henrik, Tuominen, R. K. & Christensen, Søren Brøgger, 2020, In: A C S Medicinal Chemistry Letters. 11, 5, p. 671-677 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Amaryllidaceae alkaloids from the Australasian tribe Calostemmateae with acetylcholinesterase inhibitory activity

      Søvsø Jensen, B., Christensen, Søren Brøgger, Jäger, A. K. & Rønsted, Nina, Apr 2011, In: Biochemical Systematics and Ecology. 39, 2, p. 153-155

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death

      Szalai, P., Parys, J. B., Bultynckb, G., Christensen, Søren Brøgger, Nissen, P., Møller, J. V. & Engedal, N., Dec 2018, In: Cell Calcium. 76, p. 48-61 14 p., https://doi.org/10.1016/j.ceca.2018.09.005.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)

      Stafford, G. I., Birer, C., Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H., Jäger, A. & Rønsted, Nina, Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Mild psychoactive constituents of Mentha aquatica L.

      Stafford, G. I., Almqvist, J. P., Vangsøe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A., Jäger, A. K. & van Staden, J., 2008, In: South African Journal of Botany. 2, p. 389

      Research output: Contribution to journal › Conference abstract in journal › Research

    32. Published

      NEW PROAZULENE GUAIANOLIDES FROM THAPSIA-VILLOSA

      Smitt, U. W., Cornett, Claus, Andersen, A., Christensen, Søren Brøgger & Avato, P., 1990, In: Journal of Natural Products. 53, 6, p. 1479-1484 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Nortrilobolide, a new potent guaianolide secretagogue from Thapsia garganica

      Smitt, U. W. & Christensen, Søren Brøgger, 25 Apr 1991, In: Planta Medica. 57, 2, p. 196-197 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      HYDROINDENE SESQUITERPENES FROM THAPSIA-VILLOSA

      Smitt, U. W., Cornett, Claus, Norup, E. & Christensen, Søren Brøgger, 1990, In: Phytochemistry. 29, 3, p. 873-875 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Carroll rearrangement to construct the norneolignan skeleton

      Skytte, D. M., Rasmussen, H. B. & Christensen, Søren Brøgger, 2008, In: Natural Product Research. 22, 2, p. 116-123

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase

      Skytte, D. M., Møller, J. V., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M., Olsen, C. E. & Christensen, Søren Brøgger, 2010, In: Bioorganic & Medicinal Chemistry. 18, 15, p. 5634-5646 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida

      Sittie, A. A., Lemmich, E., Olsen, C. E., Hviid, Lars, Kharazmi, A., Nkrumah, F. K. & Christensen, Søren Brøgger, 1999, In: Planta Medica. 65, 3, p. 259-61 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Alkamides from Phyllanthus fraternus

      Sittie, A. A., Lemmich, E., Olsen, C. E., Hviid, Lars & Christensen, Søren Brøgger, 1998, In: Planta Medica. 64, 2, p. 192-3 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Applying linear interaction energy method for rational design of noncompetitive allosteric inhibitors of the sarco- and endoplasmic reticulum calcium-ATPase

      Singh, P., Mhaka, A. M., Christensen, Søren Brøgger, Gray, J. J., Denmeade, S. R. & Isaacs, J. T., 21 Apr 2005, In: Journal of Medicinal Chemistry. 48, 8, p. 3005-3014 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Evaluation of Medicinal Plants from Chile

      Simonsen, H. T., Guzman, A., Adsersen, A., Christensen, Søren Brøgger & Mølgaard, Per, 2008.

      Research output: Contribution to conference › Conference abstract for conference › Research

    41. Published

      Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis

      Simonsen, H. T., Weitzel, C. & Christensen, Søren Brøgger, 2013, Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. Ramawat, K. G. & Mérillon, J-M. (eds.). Springer, p. 3069-3098 30 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    42. Published

      S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis

      Sheykhzade, Majid, Smajilovic, S., Issa, A., Haunsø, Stig, Christensen, Søren Brøgger & Tfelt-Hansen, J., 28 Sep 2008, In: European Journal of Pharmacology. 593, 1-3, p. 79-86

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response

      Sehgal, P., Szalai, P., Praetorius, H. A., Nissen, Poul, Christensen, Søren Brøgger, Engedal, N. & Møller, J. V., 2 Oct 2017, In: Journal of Biological Chemistry. 292, 48, p. 19656-19673

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relation to AIDS

      Scharff, O., Foder, B., Thastrup, Ole, Hofmann, B., Møller, J., Ryder, L. P., Jacobsen, K. D., Langhoff, E., Dickmeiss, E. & Christensen, Søren Brøgger, 1988, In: BBA General Subjects. 972, 3, p. 257-64 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Characterization of anti-inflammatory triterpene acids from rose hip powder (Rosa canina L.)

      Saaby, Lasse, Jäger, A., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Aug 2010, In: Planta Medica. 76, 12, p. 1171

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    46. Published

      Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

      Saaby, Lasse, Jäger, A. K., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Feb 2011, In: Phytotherapy Research. 25, 2, p. 195-201

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Planternes slægtskab som skattekort til nye lægemidler

      Rønsted, Nina, Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H. & Jäger, A. K., Dec 2010, In: Lægemiddelforskning. 2010, p. 19-21

      Research output: Contribution to journal › Journal article › Communication

    48. Published

      Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae

      Rønsted, Nina, Symonds, M. R. E., Birkholm, T., Christensen, Søren Brøgger, Meerow, A. W., Schmidt, M. M., Mølgaard, Per, Petersen, G., Rasmussen, N., van Staden, J., Stafford, G. I. & Jäger, A., 14 Sep 2012, In: BMC Evolutionary Biology. 12, 12 p., 182.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa

      Rubal, J. J., Moreno-Dorado, F. J., Guerra, F. M., Jorge, Z. D., Galán, M. D. C., Salido, G. M., Christensen, Søren Brøgger, Søhoel, H. & Massanet, G. M., 2010, In: Planta Medica. 76, 3, p. 284-290

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

      Rubal, J. J., Guerra, F. M., Moreno-Dorado, F. J., Jorge, Z. D., Massanet, G. M., Søhoel, H., Smitt, U. W., Frydenvang, Karla Andrea, Christensen, Søren Brøgger, Nielsen, C. & Eriksson, M., 2006, In: Journal of Natural Products. 69, 11, p. 1566-71 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 1300951