Søren Brøgger Christensen
Professor emeritus, Professor, emeritus
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Prenylated acetophenones from Melicope obscura and Melicope obtusifolia ssp. obtusifolia var. arborea and their distribution in Rutaceae
Adsersen, A., Smitt, U. W., Simonsen, H. T., Christensen, Søren Brøgger & Jaroszewski, J. W., 2007, In: Biochemical Systematics and Ecology. 35, 7, p. 447-453Research output: Contribution to journal › Journal article › Research › peer-review
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The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response
Ali, H., Christensen, Søren Brøgger, Foreman, J. C., Pearce, F. L., Piotrowski, W. & Thastrup, Ole, 1985, In: British Journal of Pharmacology. 85, 3, p. 705-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN
Andersen, A., Cornett, Claus, Lauridsen, A., Olsen, C. E. & Christensen, Søren Brøgger, 1994, In: Acta Chemica Scandinavica. Supplementum. 48, 4, p. 340-346 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CA2+-ATPASE INHIBITORY ACTIVITY OF A LOCKED ANALOG OF THAPSIGARGIN
Andersen, A., Treiman, M., Poulsen, J. C. J., Cornett, Claus, Moldt, P., Olsen, C. E. & Christensen, Søren Brøgger, 1994, In: Bioorganic & Medicinal Chemistry Letters. 4, 5, p. 657-660 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Localization and in-vivo characterization of Thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis
Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, Kirsten, Andersen-Ranberg, Johan, Nyberg, N., Christensen, Søren Brøgger & Simonsen, H. T., 2017, In: Plant Physiology. 174, 1, p. 56-72 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy
Andersen, T. B., Rasmussen, S. A., Christensen, Søren Brøgger & Simonsen, H. T., Jan 2019, In: Phytochemistry. 157, https://doi.org/10.1016/j.phytochem.2018.10.027, p. 168-174 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isorhamnetin3-(2,6-dirhamnosylgalactoside)-7-rhamnoside and 3-(6-rhamnosylgalactoside)-7-rhamnoside from Rhazya stricta
Andersen, W. K., Omar, A. A. & Christensen, Søren Brøgger, 23 Dec 1986, In: Phytochemistry. 26, 1, p. 291-294 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Localization of the acyl groups in proazulene guaianolides from Thapsia transtagana and Thapsia garganica
Avato, P., Cornett, Claus, Andersen, A., Smitt, U. W. & Christensen, Søren Brøgger, 1993, In: Journal of Natural Products. 56, 3, p. 411-415 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1
Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Amaryllidaceae alkaloids from Rauhia multiflora (Kunth) Ravenna
Birkholm, T., Rasmussen, N., Christensen, Søren Brøgger, Jäger, A. & Rønsted, Nina, Aug 2011, In: Planta Medica. 77, 12, PG12.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Structural elucidation and partial synthesis of 3-hydroxyheterodendrin, a cyanogenic glucoside from Acacia sieberiana var. woodii
Brimer, L., Christensen, Søren Brøgger, Jaroszewski, J. W. & Nartey, F., 1981, In: Phytochemistry. 20, 9, p. 2221-2223 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2-β-d-Glucopyranosyloxy-2-methylpropanol in Acacia sieberana var. woodii
Brimer, L., Christensen, Søren Brøgger & Nartey, F., 1982, In: Phytochemistry. 21, 8, p. 2005-2007 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ancistrocladinium A and B, the first N,C-coupled naphthyldihydroisoquinoline alkaloids, from a Congolese Ancistrocladus species
Bringmann, G., Kajahn, I., Reichert, M., Pedersen, S. E. H., Faber, J. H., Gulder, T., Brun, R., Christensen, Søren Brøgger, Ponte-Sucre, A., Moll, H., Heubl, G. & Mudogo, V., 8 Dec 2006, In: Journal of Organic Chemistry. 71, 25, p. 9348-9356 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ancistrotanzanine C and related 5,1’- and 7,3’- coupled naphtylisoquinoline alkaloids from Ancistrocladus tanzaniensis
Bringmann, G., Dreyer, M., Faber, J. H., Dalsgaard, P. W., Stærk, Dan, Jaroszewski, J. W., Ndangalasi, H., Mbago, F., Brun, R. & Christensen, Søren Brøgger, 2004, In: Journal of Natural Products. 67, p. 743-748Research output: Contribution to journal › Journal article › Research › peer-review
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Ancistrotanzanine A, the first 5,3’-coupled naphtylisoquinoline alkaloid, and two further, 5,8’-linked related compounds from the newly described species Ancistrocladus tanzaniensis
Bringmann, G., Dreyer, M., Faber, J. H., Dalsgaard, P. W., Stærk, Dan, Jaroszewski, J. W., Ndangalasi, H., Mbago, F., Brun, R., Reichert, M., Maksimenka, K. & Christensen, Søren Brøgger, 2003, In: Journal of Natural Products. 66, p. 1159-1165Research output: Contribution to journal › Journal article › Research › peer-review
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Incorporation of the crossfire Beilstein database into the organic chemistry curriculum at the Royal Danish School of Pharmacy
Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 1 Jun 2002, In: Journal of Chemical Education. 79, 6, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of histamine releasing guaianolides from Thapsia species
Christensen, Søren Brøgger, Norup, E., Rasmussen, U. & Øgaard Madsen, J., 1984, In: Phytochemistry. 23, 8, p. 1659-1663 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo
Chen, M., Christensen, Søren Brøgger, Zhai, L., Rasmussen, M. H., Theander, Thor Grundtvig, Frøkjær, Sven, Steffansen, B., Davidsen, J. & Kharazmi, A., 1997, In: Journal of Infectious Diseases. 176, 5, p. 1327-33 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection
Chen, M., Theander, Thor Grundtvig, Christensen, Søren Brøgger, Hviid, Lars, Zhai, L. & Kharazmi, A., 1994, In: Antimicrobial Agents and Chemotherapy. 38, 7, p. 1470-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani
Chen, M., Christensen, Søren Brøgger, Theander, Thor Grundtvig & Kharazmi, A., 1994, In: Antimicrobial Agents and Chemotherapy. 38, 6, p. 1339-44 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones
Chen, M., Zhai, L., Christensen, Søren Brøgger, Theander, Thor Grundtvig & Kharazmi, A., 2001, In: Antimicrobial Agents and Chemotherapy. 45, 7, p. 2023-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania
Chen, M., Christensen, Søren Brøgger, Blom, J., Lemmich, E., Nadelmann, L., Fich, K., Theander, Thor Grundtvig & Kharazmi, A., 1993, In: Antimicrobial Agents and Chemotherapy. 37, 12, p. 2550-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An antileishmanial chalcone from Chinese licorice roots
Christensen, Søren Brøgger, Ming, C., Andersen, L., Hjørne, U., Olsen, C. E., Cornett, Claus, Theander, Thor Grundtvig & Kharazmi, A., 1994, In: Planta Medica. 60, 2, p. 121-3 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sesquiterpenoids from Thapsia species and medicinal chemistry of the thapsigargins.
Christensen, Søren Brøgger, Andersen, A. & Smitt, U. W., 1997, In: Fortschritte der Chemie organischer Naturstoffe. Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles. 71, p. 129-167 39 p.Research output: Contribution to journal › Review › Research › peer-review
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Thapsigargin, constitution of a sesquiterpene lactone histamine liberator from thapsia garganica
Christensen, Søren Brøgger, Rasmussen, U. & Christophersen, C., 1980, In: Tetrahedron Letters. 21, 39, p. 3829-3830 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Drugs for the neglected disease malaria based on natural products
Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 1 Jan 2011, Bioactive Compounds from Natural Sources: Natural Products as Lead Compounds in Drug Discovery, Second Edition. CRC Press, p. 525-550 26 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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1-β-vicianosyl-(S)-2-methylbutyrate, a 1-O-acylglycoside from Acacia sieberana var. Woodii
Christensen, Søren Brøgger, Brimer, L. & Nartey, F., 1982, In: Phytochemistry. 21, 11, p. 2683-2685 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Atriplex nummularia, a source for the two molluscicide saponins: Hederagenin-3-O-β-D-glucuronopyranoside and calenduloside E
Christensen, Søren Brøgger & Omar, A. A., 1 Dec 1985, In: Journal of Natural Products. 48, 1, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Absolute configurations of the histamine liberating sesquiterpene lactones thapsigargin and trilobolide
Christensen, Søren Brøgger & Norup, E., 1985, In: Tetrahedron Letters. 26, 1, p. 107-110 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ca2+-ATPase inhibitory activity of a locked analogue of thapsigargin
Christensen, Søren Brøgger, Olsen, C. E., Moldt, P., Cornett, Claus, Poulsen, J. J., Treiman, M. & Andersen, A., 1994, In: Bioorganic & Medicinal Chemistry Letters.Research output: Contribution to journal › Journal article › Research › peer-review
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Neglected diseases
Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 347-368 22 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Drugs for the neglected disease malaria based on natural products
Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2012, Bioactive compounds from natural sources: natural products as lead compounds in drug discovery. Tringali, C. (ed.). 2 ed. Boca Raton: CRC Press, p. 525-550Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Targeting thapsigargin towards tumors
Christensen, Søren Brøgger, Doan, T. Q. N., Paulsen, E. S., Sehgal, P., Møller, J. V., Nissen, P., Denmeade, S. R., Isaacs, J. T. & Dionne, C. A., 2015, In: Steroids. 97, p. 2-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Drugs and drug leads based on natural products for treatment and prophylaxis of malaria
Christensen, Søren Brøgger, 25 Feb 2015, Evidence-based validation of herbal medicine: Elsevier. Amsterdam, p. 307-319Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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The pharmacophore of thapsigargin
Christensen, Søren Brøgger, Skytte, D. M., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M. & Møller, J. V., Aug 2010, In: Planta Medica. 76, 12, p. 1187Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium
Christensen, Søren Brøgger, Dubois, C., Abeele, F. V., Sehgal, P., Olesen, C., Junker, S., Prevarskaya, N. & Møller, J. V., 2013, In: F E B S Journal. 280, 21, p. 5430-5440 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Natural Products that Changed Society
Christensen, Søren Brøgger, 2021, In: Biomedicines. 9, 5, 31 p., 472.Research output: Contribution to journal › Review › Research › peer-review
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Derivatives of thapsigargin as probes of its binding site on endoplasmic reticulum Ca2+ ATPase. Stereoselectivity and important functional groups
Christensen, Søren Brøgger, Andersen, A., Poulsen, J. C. J. & Treiman, M., 13 Dec 1993, In: FEBS Letters. 335, 3, p. 345-348 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Toxicodynamics of tumour promoters of mouse skin III. Specific binding of the tumour promoter thapsigargin as measured by the cold-acetone filter assay
Christensen, Søren Brøgger, Hergenhahn, M., Roeser, H. & Hecker, E., 1 May 1992, In: Journal of Cancer Research and Clinical Oncology. 118, 5, p. 344-348 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development
Christensen, Søren Brøgger, Simonsen, H. T., Engedal, N., Nissen, P., Møller, J. V., Denmeade, S. R. & Isaacs, J. T., 2021, In: Progress in the chemistry of organic natural products. 115, p. 59-114Research output: Contribution to journal › Review › Research › peer-review
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Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams
Christensen, Søren Brøgger, 2021, In: Molecules. 26, 19, 31 p., 6057.Research output: Contribution to journal › Review › Research › peer-review
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Validation of anti-malarial leads from natural products and traditional medicine for treatment of malaria
Christensen, Søren Brøgger, 2022, In Evidence-Based validation of herbal medicine. Mukherjee, P. K. (ed.). 2 ed. Amsterdam: Elsevier, p. 389-407Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Incorporation of the Cross Fire Beilstein database in the organic chemistry curriculum at the Royal Danish School of Pharmacy
Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 2002, In: Journal of Chemical Education. 79, p. 765-768Research output: Contribution to journal › Journal article › Research
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A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells
Christensen, Søren Brøgger, Skytte, D. M., Denmeade, S. R., Dionne, C., Møller, J. V., Nissen, P. & Isaacs, J. T., 2009, In: Anti-Cancer Agents in Medicinal Chemistry. 9, 3, p. 276-294Research output: Contribution to journal › Journal article › Research › peer-review
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Neglected diseases
Christensen, Søren Brøgger, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 341-358Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Preparations of deuterium labelled guvacine and isoguvacine
Christensen, Søren Brøgger & Krogsgaard-Larsen, Povl, 1 Jan 1980, In: Journal of Labelled Compounds and Radiopharmaceuticals. 17, 2, p. 191-202 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides
Christensen, Søren Brøgger, 2022, In: Molecules. 27, 17, 29 p., 5648.Research output: Contribution to journal › Review › Research › peer-review
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Concise Synthesis of Thapsigargin from Nortrilobolide
Crestey, F., Toma, M. & Christensen, Søren Brøgger, 8 Sep 2015, In: Tetrahedron Letters. 56, 43, p. 5896-5898 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life
Dao, T. T., Sehgal, P., Thanh Tung, T., Møller, J. V., Nielsen, J., Palmgren, Michael, Christensen, Søren Brøgger & Fuglsang, Anja Thoe, 2016, In: P L o S One. 11, 9, 19 p., e0163260.Research output: Contribution to journal › Journal article › Research › peer-review
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Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy (Science Translational Medicine)
Denmeade, S. R., Mhaka, A. M., Rosen, D. M., Brennen, W. N., Dalrymple, S., Dach, I., Olesen, C., Gurel, B., DeMarzo, A. M., Wilding, G., Carducci, M. A., Dionne, C. A., Møller, J. V., Nissen, Poul, Christensen, Søren Brøgger & Isaacs, J. T., 18 Jul 2012, In: Science Translational Medicine. 4, 143, 143er4.Research output: Contribution to journal › Comment/debate › Research › peer-review
ID: 1300951
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The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed
Research output: Contribution to journal › Journal article › Research › peer-review
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Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae
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303
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Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life
Research output: Contribution to journal › Journal article › Research › peer-review
Published