Stephan Pless
Professor
Biopharmaceuticals
Jagtvej 162
2100 København Ø
- Published
A New Method to Detect Intra- and Extracellular Conformational Changes in Ion Channels with High Temporal Resolution
Wulf, M. & Pless, Stephan, 3 Feb 2017, In: Biophysical Journal. 12, 3, p. 285A-285AResearch output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
A Semi-Synthetic Approach to Engineer Ligand- and Voltage-Gated Ion Channels in Live Cells
Khoo, K. K., Galleano, I. & Pless, Stephan, 2019, p. 274A-274A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue
Pless, Stephan, Millen, K. S., Hanek, A. P., Lynch, J. W., Lester, H. A., Lummis, S. C. R. & Dougherty, D. A., 22 Oct 2008, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 28, 43, p. 10937-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists
Pless, Stephan, Hanek, A. P., Price, K. L., Lynch, J. W., Lester, H. A., Dougherty, D. A. & Lummis, S. C. R., Apr 2011, In: Molecular Pharmacology. 79, 4, p. 742-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A conserved residue cluster that governs kinetics of ATP-dependent gating of Kir6.2 potassium channels
Zhang, R. S., Wright, J., Pless, Stephan, Nunez, J., Kim, R. Y., Li, J. B. W., Yang, R., Ahern, C. A. & Kurata, H. T., 2015, In: The Journal of Biological Chemistry. 290, 25, p. 15450 –15461 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel
Pless, Stephan, Niciforovic, A. P., Galpin, J. D., Nunez, J., Kurata, H. T. & Ahern, C. A., 2013, In: Nature Communications. 4, p. 1784Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A selectivity filter at the intracellular end of the acid-sensing ion channel pore
Lynagh, T., Flood, E., Boiteux, C., Wulf, M., Komnatnyy, V. V., Colding, J. M., Allen, T. W. & Pless, Stephan, 12 May 2017, In: eLife. 6, 21 p., 24630.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins
Pless, Stephan & Sivilotti, L. G., 1 Apr 2018, In: Current Opinion in Physiology. 2, p. 19-26 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
ATP signaling in pancreatic cancer: the P2X7 receptor
Magni, Lara, Bouazzi, R., Christensen, Nynne, Tozzi, M., Poulsen, M., Johansen, J., Pless, Stephan & Novak, Ivana, 2022, In: Acta Physiologica. 236, S725, p. 661-661Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Acid-sensing ion channels as potential therapeutic targets
Heusser, Stephanie & Pless, Stephan, 2021, In: Trends in Pharmacological Sciences. 42, 12, p. 1035-1050Research output: Contribution to journal › Review › Research › peer-review
- Published
Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes
Lynagh, T., Mikhaleva, Y., Colding, J. M., Glover, J. C. & Pless, Stephan, 14 Aug 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 33, p. 8430-8435Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains
Pless, Stephan, Elstone, F. D., Niciforovic, A. P., Galpin, J. D., Yang, R., Kurata, H. T. & Ahern, C. A., May 2014, In: Journal of General Physiology. 143, 5, p. 645-56 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Atom-by-atom engineering of voltage-gated ion channels: Magnified insights into function and pharmacology
Pless, Stephan, Kim, R. Y., Ahern, C. A. & Kurata, H. T., 30 Jan 2015, In: The Journal of Physiology. 593, 12, p. 2627–2634 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Atomic basis for therapeutic activation of neuronal potassium channels
Kim, R. Y., Yau, M. C., Galpin, J. D., Seebohm, G., Ahern, C. A., Pless, Stephan & Kurata, H. T., 2015, In: Nature Communications. 6, p. 1-11 11 p., 8116.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Caught in the act: multiple binding sites for memantine
Pless, Stephan, 2014, In: Structure. 22, 10, p. 1373-4 2 p.Research output: Contribution to journal › Journal article › Commissioned › peer-review
- Published
Characterizing Conformational Changes of ASIC1a During Gating and Peptide Modulation
Heusser, Stephanie, Sheikh, Zeshan Pervez, Borg, C. B., Galleano, I. & Pless, Stephan, 2021, p. 337A-337A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing
Khoo, K. K., Galleano, I., Gasparri, F., Wieneke, R., Harms, Hendrik, Poulsen, Mette Homann, Chua, H. C., Wulf, M., Tampé, R. & Pless, Stephan, 1 Dec 2020, In: Nature Communications. 11, 1, 10 p., 2284.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational decoupling in acidsensing ion channels uncovers mechanism and stoichiometry of PcTx1mediated inhibition
Heusser, Stephanie, Borg, C. B., Colding, J. M. & Pless, Stephan, 2022, In: eLife. 11, 20 p., e73384.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational variability of the glycine receptor M2 domain in response to activation by different agonists
Pless, Stephan, Dibas, M. I., Lester, H. A. & Lynch, J. W., 7 Dec 2007, In: The Journal of Biological Chemistry. 282, 49, p. 36057-67 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contributions of conserved residues at the gating interface of glycine receptors
Pless, Stephan, Leung, A. W. Y., Galpin, J. D. & Ahern, C. A., 7 Oct 2011, In: The Journal of Biological Chemistry. 286, 40, p. 35129-36 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contributions of counter-charge in a potassium channel voltage-sensor domain
Pless, Stephan, Galpin, J. D., Niciforovic, A. P. & Ahern, C. A., Sep 2011, In: Nature Chemical Biology. 7, 9, p. 617-23 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels
Lynagh, T., Flood, E., Boiteux, C., Sheikh, Zeshan Pervez, Allen, T. W. & Pless, Stephan, 3 Feb 2020, In: The Journal of general physiology. 152, 2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits
Pless, Stephan & Lynch, J. W., Mar 2009, In: Journal of Neurochemistry. 108, 6, p. 1585-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions
Holm, Caroline Marcher, Topaktas, Asli Bahar, Dannesboe, Johs, Pless, Stephan & Heusser, Stephanie, 2024, (E-pub ahead of print) In: Biophysical Journal.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Ligand Conformations and Hetero-Liganded States on P2X2 Receptors
Gasparri, F., Wengel, J., Grutter, T. & Pless, Stephan, 3 Feb 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, p. 421A-421A 2069-Pos.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Elucidating the Function and Cell-Specific Interactions of P2X7 Receptor Variants Linked to Mental Disorders
Poulsen, Mette Homann, Fang, J. & Pless, Stephan, 2019, p. 109A-110A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels
Kasimova, M. A., Lynagh, T., Sheikh, Zeshan Pervez, Granata, D., Borg, C. B., Carnevale, V. & Pless, Stephan, 2020, In: Biophysical Journal. 118, 4, p. 861-872 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytes
Rivera-Acevedo, R. E., Pless, Stephan, Schwarz, S. K. W. & Ahern, C. A., 1 Jan 2013, In: Channels (Austin). 7, 1, p. 47-50 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular quaternary ammonium blockade of transient receptor potential vanilloid subtype 1 channels expressed in Xenopus laevis oocytes
Rivera-Acevedo, R. E., Pless, Stephan, Schwarz, S. K. W. & Ahern, C. A., Dec 2012, In: Molecular Pharmacology. 82, 6, p. 1129-35 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener
Wang, A. W., Yau, M. C., Wang, C. K., Sharmin, N., Yang, R. Y., Pless, Stephan & Kurata, H. T., 30 Aug 2018, In: Journal of General Physiology. 150, 10, p. 1432-1443 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional Characterization of Disease-Causing Mutations in the Sodium Leak Channel NALCN
wbv551, wbv551, Ameen, A. O., Chua, H. C. & Pless, Stephan, 2021, p. 10A-11A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5
Galleano, I., Harms, Hendrik, Choudhury, K., Khoo, K., Delemotte, L. & Pless, Stephan, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 33, 10 p., e2025320118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional modulation of a pH-sensitive ion channel by a transporter family
Poulsen, Mette Homann, Xue, F., Maurya, S. R., Kickinger, Stefanie, Usher, Samuel George, Wellendorph, Petrine, Lundby, Alicia & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 249aResearch output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics
Wulf, M. & Pless, Stephan, 6 Feb 2018, In: Cell Reports. 22, 6, p. 1615-1626 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology
Braun, N., Friis, S., Ihling, C., Sinz, A., Andersen, J. & Pless, Stephan, 2021, In: PLOS Biology. 19, 9, 30 p., e3001321.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How an intrinsic ligand tunes the activity of a potassium channel
Khoo, K. K. & Pless, Stephan, 22 Mar 2018, In: Journal of General Physiology. 150, 4, p. 517-520Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer
Magni, Lara, Yu, Haoran, Christensen, Nynne, Poulsen, Mette Homann, Frueh, A., Deshar, Ganga, Johansen, A. Z., Johansen, Julia Sidenius, Pless, Stephan, Jørgensen, Niklas Rye & Novak, Ivana, 2024, In: Cancer Cell International. 24, 1, 16 p., 148.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels
Pless, Stephan, Galpin, J. D., Niciforovic, A. P., Kurata, H. T. & Ahern, C. A., 2013, In: eLife. 2, p. e01289Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Illuminating the structure and function of Cys-loop receptors
Pless, Stephan & Lynch, J. W., Oct 2008, In: Clinical and Experimental Pharmacology & Physiology (Online). 35, 10, p. 1137-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Indirect Determinants of Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels
Sheikh, Zeshan Pervez, Lynagh, T., Kristensen, Anders Skov & Pless, Stephan, 2019, p. 110A-110A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Inhibitor-Induced Conformational Changes in ASIC1A
Lund, Camilla, Borg, C. B., Lynagh, T. & Pless, Stephan, 2 Feb 2018, p. 130A-130A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Intermediate state trapping of a voltage sensor
Lacroix, J. J., Pless, Stephan, Maragliano, L., Campos, F. V., Galpin, J. D., Ahern, C. A., Roux, B. & Bezanilla, F., Dec 2012, In: Journal of General Physiology. 140, 6, p. 635-52 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interplay of Nav1.5 Disease-Causing Mutations and Phosphorylation Revealed by Protein Semi-Synthesis and Molecular Dynamics Simulations
Galleano, I., Harms, Hendrik, Choudhury, K., Khoo, K. K., Delemotte, L. & Pless, Stephan, 2021, p. 288A-288A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Introduction: Applying Chemical Biology to Ion Channels
Pless, Stephan & Ahern, C. A., 2015, Applying Chemical Biology to Ion Channels. Vol. 869. p. 1-4 4 p. (Advances in Experimental Medicine and Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Investigation of Agonist Recognition and Channel Properties in a Flatworm Glutamate-Gated Chloride Channel
Callau-Vázquez, D., Pless, Stephan & Lynagh, T., 2018, In: Biochemistry. 57, 8, p. 1360-1368Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels
Sheikh, Zeshan Pervez, Lynagh, T. P. & Pless, Stephan, 2 Feb 2018, p. 24A-24A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Ion channel engineering using protein trans-splicing
Sarkar, Debayan, Harms, Hendrik, Galleano, I., Sheikh, Zeshan Pervez & Pless, Stephan, 2021, Methods in Enzymology. Elsevier, p. 19-48 30 p. (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors
Wang, Q., Pless, Stephan & Lynch, J. W., 17 Dec 2010, In: The Journal of Biological Chemistry. 285, 51, p. 40373-86 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain
Pless, Stephan & Lynch, J. W., 5 Jun 2009, In: The Journal of Biological Chemistry. 284, 23, p. 15847-56 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy
Pless, Stephan & Lynch, J. W., 2 Oct 2009, In: The Journal of Biological Chemistry. 284, 40, p. 27370-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 93715174
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Unique contributions of an arginine side chain to ligand recognition in a glutamate-gated chloride channel
Research output: Contribution to journal › Journal article › Research › peer-review
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High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics
Research output: Contribution to journal › Journal article › Research › peer-review
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A selectivity filter at the intracellular end of the acid-sensing ion channel pore
Research output: Contribution to journal › Journal article › Research › peer-review
Published