Stephan Pless

Stephan Pless

Professor

ORCID: 0000-0001-6654-114X

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  1. Published

    Unravelling the functional regulation of the NALCN sodium leak channel complex by G protein-coupled receptors

    Harms, Hendrik & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 163a

    Research output: Contribution to journal › Conference abstract in journal › Research

  2. Published

    Unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences

    Pless, Stephan & Ahern, C. A., 2013, In: Annual Review of Pharmacology and Toxicology. 53, p. 211-29 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Unique contributions of an arginine side chain to ligand recognition in a glutamate-gated chloride channel

    Lynagh, T., Komnatnyy, V. V. & Pless, Stephan, 17 Jan 2017, In: The Journal of Biological Chemistry. 292, p. 3940-3946

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results

    Chua, H. C., Servatius, H., Asatryan, B., Schaller, A., Rieubland, C., Noti, F., Seiler, J., Roten, L., Baldinger, S. H., Tanner, H., Fuhrer, J., Haeberlin, A., Lam, A., Pless, Stephan & Medeiros-Domingo, A., 1 Aug 2018, In: Clinical Research in Cardiology. 107, 8, p. 670-678 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    The suitability of high throughput automated patch clamp for physiological applications

    Obergrussberger, A., Rinke-Weiß, I., Goetze, T. A., Rapedius, M., Brinkwirth, N., Becker, N., Rotordam, M. G., Hutchison, L., Madau, P., Pau, D., Dalrymple, D., Braun, N., Friis, S., Pless, Stephan & Fertig, N., 2022, In: Journal of Physiology. 600, 2, p. 277-297

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro

    Rivera-Acevedo, R. E., Pless, Stephan, Ahern, C. A. & Schwarz, S. K. W., Jun 2011, In: Anesthesiology. 114, 6, p. 1425-34 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons

    Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Vitello, M., Chua, H. C., Pless, Stephan, Engel, D., Liégeois, J. F., Lakaye, B., Roeper, J. & Seutin, V., 2021, In: Neuropharmacology. 197, 15 p., 108722.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The current chemical biology tool box for studying ion channels

    Braun, N., Sheikh, Zeshan Pervez & Pless, Stephan, 2020, In: The Journal of Physiology. 598, 20, p. 4455-4471 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The Sodium Leak Channel Complex is Modulated by Voltage and Extracellular Calcium

    Chua, H. C., Wulf, M., wbv551, wbv551, Rasmussen, L. P. & Pless, Stephan, 7 Feb 2020, p. 499A-499A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  10. Published

    The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium

    Chua, H. C., Wulf, M., wbv551, wbv551, Rasmussen, L. P. & Pless, Stephan, Apr 2020, In: Science Advances. 6, 17, 11 p., aaz3154.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs

    Sheikh, Zeshan Pervez, Wulf, M., Friis, S., Althaus, M., Lynagh, T. & Pless, Stephan, 2021, In: Journal of General Physiology. 153, 10, 23 p., e202112899.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

    Noland, C. L., Chua, H. C., Kschonsak, M., Heusser, Stephanie, Braun, N., Chang, T., Tam, C., Tang, J., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature Communications. 13, 1, 10 p., 1416.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Structure of the human sodium leak channel NALCN

    Kschonsak, M., Chua, H. C., Noland, C. L., wbv551, wbv551, Clairfeuille, T., Bahlke, O. Ø., Ameen, A. O., Li, Z. R., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2020, In: Nature. 587, p. 313-318

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Structural architecture of the human NALCN channelosome

    Kschonsak, M., Chua, H. C., wbv551, wbv551, Chakouri, N., Noland, C. L., Schott, K., Chang, T., Tam, C., Patel, N., Arthur, C. P., Leitner, A., Ben-Johny, M., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature. 603, p. 180–186

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Stoichiometry of Toxin Binding to Acid-Sensing Ion Channels

    Borg, C. B., Lynagh, T., Haugaard-Kedstrom, L. M., Strømgaard, Kristian & Pless, Stephan, 3 Feb 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, p. 420A-420A

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  16. Published

    Role of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop Receptors

    Braun, N., Lynagh, T., Yu, R., Biggin, P. C. & Pless, Stephan, 29 Jan 2016, In: A C S Chemical Neuroscience. 7, 3, p. 339–348 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Accepted/In press

    Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels

    Sarkar, Debayan, Galleano, I., Heusser, Stephanie, Ou, S. Y., Uzun, G. R., Khoo, K. K., van der Heden van Noort, G. J., Harrison, J. S. & Pless, Stephan, 2024, (Accepted/In press) In: Cell Chemical Biology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations

    Sereikaité, Vita, Jensen, T. M. T., Bartling, Christian Reinhard Otto, Jemth, P., Pless, Stephan & Strømgaard, Kristian, 18 Oct 2018, In: ChemBioChem. 19, 20, p. 2136-2145

    Research output: Contribution to journal › Review › Research › peer-review

  19. Published

    Principles of agonist recognition in Cys-loop receptors

    Lynagh, T. P. & Pless, Stephan, 2014, In: Frontiers in Physiology. 5, p. 1-12 12 p., 160.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Phenotypic Spectrum of HCN4 Mutations: A Clinical Case

    Servatius, H., Porro, A., Pless, Stephan, Schaller, A., Asatryan, B., Tanner, H., de Marchi, S. F., Roten, L., Seiler, J., Haeberlin, A., Baldinger, S. H., Noti, F., Lam, A., Fuhrer, J., Moroni, A. & Medeiros-Domingo, A., Feb 2018, In: Circulation. Genomic and precision medicine. 11, 2, e002033.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Peptide Modulation of Acid-Sensing Ion Channels

    Borg, C. B., Haugaard-Kedstrom, L. M., Lynagh, T., Strømgaard, Kristian & Pless, Stephan, 2 Feb 2018, p. 130A-130A.

    Research output: Contribution to conference › Poster › Research

  22. Published

    Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction

    Lynagh, T., Kiontke, S., Meyhoff-Madsen, M., Gless, B. H., Johannesen, J., Kattelmann, S., Christiansen, A., Dufva, M., Laustsen, A. H., Devkota, K., Olsen, Christian Adam, Kuemmel, D., Pless, Stephan & Lohse, B., 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13709-13718 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels

    Kim, R. Y., Pless, Stephan & Kurata, H. T., 23 Oct 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 45, p. E9702–E9711

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity

    Gasparri, F., Sarkar, Debayan, Bielickaite, S., Poulsen, Mette Homann, Hauser, Alexander Sebastian & Pless, Stephan, 2022, In: British Journal of Pharmacology. 179, 14, p. 3859-3874

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    One drug-sensitive subunit is sufficient for a nearmaximal retigabine effect in KCNQ channels

    Yau, M. C., Kim, R. Y., Wang, C. K., Li, J., Ammar, T., Yang, R. Y., Pless, Stephan & Kurata, H. T., 1 Oct 2018, In: Journal of General Physiology. 215, 10, p. 1421-1431 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Molecular determinants for agonist recognition and discrimination in P2X2 receptors

    Gasparri, F., Wengel, J., Grutter, T. & Pless, Stephan, 24 May 2019, In: Journal of General Physiology. 151, 7, p. 898–911

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels

    Pless, Stephan, Galpin, J. D., Frankel, A. & Ahern, C. A., 2011, In: Nature Communications. 2, p. 351

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen

    Lynagh, T., Romero-Rojo, J. L., Lund, Camilla & Pless, Stephan, 12 Oct 2017, In: Journal of Medicinal Chemistry. 60, 19, p. 8192-8200 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Mechanism and site of action of big dynorphin on ASIC1a

    Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedström, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 13, p. 7447-7454

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Mechanism and Binding Site of the ASIC1A-Big Dynorphin Interaction

    Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedstrom, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 7 Feb 2020, In: Biophysical Journal. 118, 3, supplement 1, p. 582A-582A

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  31. Published

    Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy

    Pless, Stephan & Lynch, J. W., 2 Oct 2009, In: The Journal of Biological Chemistry. 284, 40, p. 27370-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain

    Pless, Stephan & Lynch, J. W., 5 Jun 2009, In: The Journal of Biological Chemistry. 284, 23, p. 15847-56 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors

    Wang, Q., Pless, Stephan & Lynch, J. W., 17 Dec 2010, In: The Journal of Biological Chemistry. 285, 51, p. 40373-86 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Ion channel engineering using protein trans-splicing

    Sarkar, Debayan, Harms, Hendrik, Galleano, I., Sheikh, Zeshan Pervez & Pless, Stephan, 2021, Methods in Enzymology. Elsevier, p. 19-48 30 p. (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  35. Published

    Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels

    Sheikh, Zeshan Pervez, Lynagh, T. P. & Pless, Stephan, 2 Feb 2018, p. 24A-24A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  36. Published

    Investigation of Agonist Recognition and Channel Properties in a Flatworm Glutamate-Gated Chloride Channel

    Callau-Vázquez, D., Pless, Stephan & Lynagh, T., 2018, In: Biochemistry. 57, 8, p. 1360-1368

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Introduction: Applying Chemical Biology to Ion Channels

    Pless, Stephan & Ahern, C. A., 2015, Applying Chemical Biology to Ion Channels. Vol. 869. p. 1-4 4 p. (Advances in Experimental Medicine and Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  38. Published

    Interplay of Nav1.5 Disease-Causing Mutations and Phosphorylation Revealed by Protein Semi-Synthesis and Molecular Dynamics Simulations

    Galleano, I., Harms, Hendrik, Choudhury, K., Khoo, K. K., Delemotte, L. & Pless, Stephan, 2021, p. 288A-288A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  39. Published

    Intermediate state trapping of a voltage sensor

    Lacroix, J. J., Pless, Stephan, Maragliano, L., Campos, F. V., Galpin, J. D., Ahern, C. A., Roux, B. & Bezanilla, F., Dec 2012, In: Journal of General Physiology. 140, 6, p. 635-52 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Inhibitor-Induced Conformational Changes in ASIC1A

    Lund, Camilla, Borg, C. B., Lynagh, T. & Pless, Stephan, 2 Feb 2018, p. 130A-130A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  41. Published

    Indirect Determinants of Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels

    Sheikh, Zeshan Pervez, Lynagh, T., Kristensen, Anders Skov & Pless, Stephan, 2019, p. 110A-110A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  42. Published

    Illuminating the structure and function of Cys-loop receptors

    Pless, Stephan & Lynch, J. W., Oct 2008, In: Clinical and Experimental Pharmacology & Physiology (Online). 35, 10, p. 1137-42 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels

    Pless, Stephan, Galpin, J. D., Niciforovic, A. P., Kurata, H. T. & Ahern, C. A., 2013, In: eLife. 2, p. e01289

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer

    Magni, Lara, Yu, Haoran, Christensen, Nynne, Poulsen, Mette Homann, Frueh, A., Deshar, Ganga, Johansen, A. Z., Johansen, Julia Sidenius, Pless, Stephan, Jørgensen, Niklas Rye & Novak, Ivana, 2024, In: Cancer Cell International. 24, 1, 16 p., 148.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    How an intrinsic ligand tunes the activity of a potassium channel

    Khoo, K. K. & Pless, Stephan, 22 Mar 2018, In: Journal of General Physiology. 150, 4, p. 517-520

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  46. Published

    High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology

    Braun, N., Friis, S., Ihling, C., Sinz, A., Andersen, J. & Pless, Stephan, 2021, In: PLOS Biology. 19, 9, 30 p., e3001321.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics

    Wulf, M. & Pless, Stephan, 6 Feb 2018, In: Cell Reports. 22, 6, p. 1615-1626 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Functional modulation of a pH-sensitive ion channel by a transporter family

    Poulsen, Mette Homann, Xue, F., Maurya, S. R., Kickinger, Stefanie, Usher, Samuel George, Wellendorph, Petrine, Lundby, Alicia & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 249a

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  49. Published

    Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5

    Galleano, I., Harms, Hendrik, Choudhury, K., Khoo, K., Delemotte, L. & Pless, Stephan, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 33, 10 p., e2025320118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Functional Characterization of Disease-Causing Mutations in the Sodium Leak Channel NALCN

    wbv551, wbv551, Ameen, A. O., Chua, H. C. & Pless, Stephan, 2021, p. 10A-11A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

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