Stephan Pless

Stephan Pless

Professor

ORCID: 0000-0001-6654-114X

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  1. Published

    Mechanism and Binding Site of the ASIC1A-Big Dynorphin Interaction

    Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedstrom, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 7 Feb 2020, In: Biophysical Journal. 118, 3, supplement 1, p. 582A-582A

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  2. Published

    Mechanism and site of action of big dynorphin on ASIC1a

    Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedström, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 13, p. 7447-7454

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen

    Lynagh, T., Romero-Rojo, J. L., Lund, Camilla & Pless, Stephan, 12 Oct 2017, In: Journal of Medicinal Chemistry. 60, 19, p. 8192-8200 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels

    Pless, Stephan, Galpin, J. D., Frankel, A. & Ahern, C. A., 2011, In: Nature Communications. 2, p. 351

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Molecular determinants for agonist recognition and discrimination in P2X2 receptors

    Gasparri, F., Wengel, J., Grutter, T. & Pless, Stephan, 24 May 2019, In: Journal of General Physiology. 151, 7, p. 898–911

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    One drug-sensitive subunit is sufficient for a nearmaximal retigabine effect in KCNQ channels

    Yau, M. C., Kim, R. Y., Wang, C. K., Li, J., Ammar, T., Yang, R. Y., Pless, Stephan & Kurata, H. T., 1 Oct 2018, In: Journal of General Physiology. 215, 10, p. 1421-1431 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity

    Gasparri, F., Sarkar, Debayan, Bielickaite, S., Poulsen, Mette Homann, Hauser, Alexander Sebastian & Pless, Stephan, 2022, In: British Journal of Pharmacology. 179, 14, p. 3859-3874

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels

    Kim, R. Y., Pless, Stephan & Kurata, H. T., 23 Oct 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 45, p. E9702–E9711

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction

    Lynagh, T., Kiontke, S., Meyhoff-Madsen, M., Gless, B. H., Johannesen, J., Kattelmann, S., Christiansen, A., Dufva, M., Laustsen, A. H., Devkota, K., Olsen, Christian Adam, Kuemmel, D., Pless, Stephan & Lohse, B., 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13709-13718 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Peptide Modulation of Acid-Sensing Ion Channels

    Borg, C. B., Haugaard-Kedstrom, L. M., Lynagh, T., Strømgaard, Kristian & Pless, Stephan, 2 Feb 2018, p. 130A-130A.

    Research output: Contribution to conference › Poster › Research

  11. Published

    Phenotypic Spectrum of HCN4 Mutations: A Clinical Case

    Servatius, H., Porro, A., Pless, Stephan, Schaller, A., Asatryan, B., Tanner, H., de Marchi, S. F., Roten, L., Seiler, J., Haeberlin, A., Baldinger, S. H., Noti, F., Lam, A., Fuhrer, J., Moroni, A. & Medeiros-Domingo, A., Feb 2018, In: Circulation. Genomic and precision medicine. 11, 2, e002033.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Principles of agonist recognition in Cys-loop receptors

    Lynagh, T. P. & Pless, Stephan, 2014, In: Frontiers in Physiology. 5, p. 1-12 12 p., 160.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations

    Sereikaité, Vita, Jensen, T. M. T., Bartling, Christian Reinhard Otto, Jemth, P., Pless, Stephan & Strømgaard, Kristian, 18 Oct 2018, In: ChemBioChem. 19, 20, p. 2136-2145

    Research output: Contribution to journal › Review › Research › peer-review

  14. Accepted/In press

    Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels

    Sarkar, Debayan, Galleano, I., Heusser, Stephanie, Ou, S. Y., Uzun, G. R., Khoo, K. K., van der Heden van Noort, G. J., Harrison, J. S. & Pless, Stephan, 2024, (Accepted/In press) In: Cell Chemical Biology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Role of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop Receptors

    Braun, N., Lynagh, T., Yu, R., Biggin, P. C. & Pless, Stephan, 29 Jan 2016, In: A C S Chemical Neuroscience. 7, 3, p. 339–348 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Stoichiometry of Toxin Binding to Acid-Sensing Ion Channels

    Borg, C. B., Lynagh, T., Haugaard-Kedstrom, L. M., Strømgaard, Kristian & Pless, Stephan, 3 Feb 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, p. 420A-420A

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  17. Published

    Structural architecture of the human NALCN channelosome

    Kschonsak, M., Chua, H. C., wbv551, wbv551, Chakouri, N., Noland, C. L., Schott, K., Chang, T., Tam, C., Patel, N., Arthur, C. P., Leitner, A., Ben-Johny, M., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature. 603, p. 180–186

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Structure of the human sodium leak channel NALCN

    Kschonsak, M., Chua, H. C., Noland, C. L., wbv551, wbv551, Clairfeuille, T., Bahlke, O. Ø., Ameen, A. O., Li, Z. R., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2020, In: Nature. 587, p. 313-318

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

    Noland, C. L., Chua, H. C., Kschonsak, M., Heusser, Stephanie, Braun, N., Chang, T., Tam, C., Tang, J., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature Communications. 13, 1, 10 p., 1416.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs

    Sheikh, Zeshan Pervez, Wulf, M., Friis, S., Althaus, M., Lynagh, T. & Pless, Stephan, 2021, In: Journal of General Physiology. 153, 10, 23 p., e202112899.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium

    Chua, H. C., Wulf, M., wbv551, wbv551, Rasmussen, L. P. & Pless, Stephan, Apr 2020, In: Science Advances. 6, 17, 11 p., aaz3154.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The Sodium Leak Channel Complex is Modulated by Voltage and Extracellular Calcium

    Chua, H. C., Wulf, M., wbv551, wbv551, Rasmussen, L. P. & Pless, Stephan, 7 Feb 2020, p. 499A-499A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  23. Published

    The current chemical biology tool box for studying ion channels

    Braun, N., Sheikh, Zeshan Pervez & Pless, Stephan, 2020, In: The Journal of Physiology. 598, 20, p. 4455-4471 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons

    Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Vitello, M., Chua, H. C., Pless, Stephan, Engel, D., Liégeois, J. F., Lakaye, B., Roeper, J. & Seutin, V., 2021, In: Neuropharmacology. 197, 15 p., 108722.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro

    Rivera-Acevedo, R. E., Pless, Stephan, Ahern, C. A. & Schwarz, S. K. W., Jun 2011, In: Anesthesiology. 114, 6, p. 1425-34 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The suitability of high throughput automated patch clamp for physiological applications

    Obergrussberger, A., Rinke-Weiß, I., Goetze, T. A., Rapedius, M., Brinkwirth, N., Becker, N., Rotordam, M. G., Hutchison, L., Madau, P., Pau, D., Dalrymple, D., Braun, N., Friis, S., Pless, Stephan & Fertig, N., 2022, In: Journal of Physiology. 600, 2, p. 277-297

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results

    Chua, H. C., Servatius, H., Asatryan, B., Schaller, A., Rieubland, C., Noti, F., Seiler, J., Roten, L., Baldinger, S. H., Tanner, H., Fuhrer, J., Haeberlin, A., Lam, A., Pless, Stephan & Medeiros-Domingo, A., 1 Aug 2018, In: Clinical Research in Cardiology. 107, 8, p. 670-678 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Unique contributions of an arginine side chain to ligand recognition in a glutamate-gated chloride channel

    Lynagh, T., Komnatnyy, V. V. & Pless, Stephan, 17 Jan 2017, In: The Journal of Biological Chemistry. 292, p. 3940-3946

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences

    Pless, Stephan & Ahern, C. A., 2013, In: Annual Review of Pharmacology and Toxicology. 53, p. 211-29 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Unravelling the functional regulation of the NALCN sodium leak channel complex by G protein-coupled receptors

    Harms, Hendrik & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 163a

    Research output: Contribution to journal › Conference abstract in journal › Research

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