Stephan Pless

Stephan Pless

Professor

ORCID: 0000-0001-6654-114X

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  1. Published

    A New Method to Detect Intra- and Extracellular Conformational Changes in Ion Channels with High Temporal Resolution

    Wulf, M. & Pless, Stephan, 3 Feb 2017, In: Biophysical Journal. 12, 3, p. 285A-285A

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  2. Published

    A Semi-Synthetic Approach to Engineer Ligand- and Voltage-Gated Ion Channels in Live Cells

    Khoo, K. K., Galleano, I. & Pless, Stephan, 2019, p. 274A-274A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  3. Published

    A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue

    Pless, Stephan, Millen, K. S., Hanek, A. P., Lynch, J. W., Lester, H. A., Lummis, S. C. R. & Dougherty, D. A., 22 Oct 2008, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 28, 43, p. 10937-42 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists

    Pless, Stephan, Hanek, A. P., Price, K. L., Lynch, J. W., Lester, H. A., Dougherty, D. A. & Lummis, S. C. R., Apr 2011, In: Molecular Pharmacology. 79, 4, p. 742-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A conserved residue cluster that governs kinetics of ATP-dependent gating of Kir6.2 potassium channels

    Zhang, R. S., Wright, J., Pless, Stephan, Nunez, J., Kim, R. Y., Li, J. B. W., Yang, R., Ahern, C. A. & Kurata, H. T., 2015, In: The Journal of Biological Chemistry. 290, 25, p. 15450 –15461 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel

    Pless, Stephan, Niciforovic, A. P., Galpin, J. D., Nunez, J., Kurata, H. T. & Ahern, C. A., 2013, In: Nature Communications. 4, p. 1784

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    A selectivity filter at the intracellular end of the acid-sensing ion channel pore

    Lynagh, T., Flood, E., Boiteux, C., Wulf, M., Komnatnyy, V. V., Colding, J. M., Allen, T. W. & Pless, Stephan, 12 May 2017, In: eLife. 6, 21 p., 24630.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins

    Pless, Stephan & Sivilotti, L. G., 1 Apr 2018, In: Current Opinion in Physiology. 2, p. 19-26 8 p.

    Research output: Contribution to journal › Review › Research › peer-review

  9. Published

    ATP signaling in pancreatic cancer: the P2X7 receptor

    Magni, Lara, Bouazzi, R., Christensen, Nynne, Tozzi, M., Poulsen, M., Johansen, J., Pless, Stephan & Novak, Ivana, 2022, In: Acta Physiologica. 236, S725, p. 661-661

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  10. Published

    Acid-sensing ion channels as potential therapeutic targets

    Heusser, Stephanie & Pless, Stephan, 2021, In: Trends in Pharmacological Sciences. 42, 12, p. 1035-1050

    Research output: Contribution to journal › Review › Research › peer-review

  11. Published

    Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes

    Lynagh, T., Mikhaleva, Y., Colding, J. M., Glover, J. C. & Pless, Stephan, 14 Aug 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 33, p. 8430-8435

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains

    Pless, Stephan, Elstone, F. D., Niciforovic, A. P., Galpin, J. D., Yang, R., Kurata, H. T. & Ahern, C. A., May 2014, In: Journal of General Physiology. 143, 5, p. 645-56 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Atom-by-atom engineering of voltage-gated ion channels: Magnified insights into function and pharmacology

    Pless, Stephan, Kim, R. Y., Ahern, C. A. & Kurata, H. T., 30 Jan 2015, In: The Journal of Physiology. 593, 12, p. 2627–2634 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Atomic basis for therapeutic activation of neuronal potassium channels

    Kim, R. Y., Yau, M. C., Galpin, J. D., Seebohm, G., Ahern, C. A., Pless, Stephan & Kurata, H. T., 2015, In: Nature Communications. 6, p. 1-11 11 p., 8116.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Caught in the act: multiple binding sites for memantine

    Pless, Stephan, 2014, In: Structure. 22, 10, p. 1373-4 2 p.

    Research output: Contribution to journal › Journal article › Commissioned › peer-review

  16. Published

    Characterizing Conformational Changes of ASIC1a During Gating and Peptide Modulation

    Heusser, Stephanie, Sheikh, Zeshan Pervez, Borg, C. B., Galleano, I. & Pless, Stephan, 2021, p. 337A-337A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  17. Published

    Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing

    Khoo, K. K., Galleano, I., Gasparri, F., Wieneke, R., Harms, Hendrik, Poulsen, Mette Homann, Chua, H. C., Wulf, M., Tampé, R. & Pless, Stephan, 1 Dec 2020, In: Nature Communications. 11, 1, 10 p., 2284.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Conformational decoupling in acidsensing ion channels uncovers mechanism and stoichiometry of PcTx1mediated inhibition

    Heusser, Stephanie, Borg, C. B., Colding, J. M. & Pless, Stephan, 2022, In: eLife. 11, 20 p., e73384.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Conformational variability of the glycine receptor M2 domain in response to activation by different agonists

    Pless, Stephan, Dibas, M. I., Lester, H. A. & Lynch, J. W., 7 Dec 2007, In: The Journal of Biological Chemistry. 282, 49, p. 36057-67 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Contributions of conserved residues at the gating interface of glycine receptors

    Pless, Stephan, Leung, A. W. Y., Galpin, J. D. & Ahern, C. A., 7 Oct 2011, In: The Journal of Biological Chemistry. 286, 40, p. 35129-36 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Contributions of counter-charge in a potassium channel voltage-sensor domain

    Pless, Stephan, Galpin, J. D., Niciforovic, A. P. & Ahern, C. A., Sep 2011, In: Nature Chemical Biology. 7, 9, p. 617-23 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels

    Lynagh, T., Flood, E., Boiteux, C., Sheikh, Zeshan Pervez, Allen, T. W. & Pless, Stephan, 3 Feb 2020, In: The Journal of general physiology. 152, 2

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits

    Pless, Stephan & Lynch, J. W., Mar 2009, In: Journal of Neurochemistry. 108, 6, p. 1585-94 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. E-pub ahead of print

    Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions

    Holm, Caroline Marcher, Topaktas, Asli Bahar, Dannesboe, Johs, Pless, Stephan & Heusser, Stephanie, 2024, (E-pub ahead of print) In: Biophysical Journal.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Effects of Ligand Conformations and Hetero-Liganded States on P2X2 Receptors

    Gasparri, F., Wengel, J., Grutter, T. & Pless, Stephan, 3 Feb 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, p. 421A-421A 2069-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  26. Published

    Elucidating the Function and Cell-Specific Interactions of P2X7 Receptor Variants Linked to Mental Disorders

    Poulsen, Mette Homann, Fang, J. & Pless, Stephan, 2019, p. 109A-110A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  27. Published

    Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels

    Kasimova, M. A., Lynagh, T., Sheikh, Zeshan Pervez, Granata, D., Borg, C. B., Carnevale, V. & Pless, Stephan, 2020, In: Biophysical Journal. 118, 4, p. 861-872 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytes

    Rivera-Acevedo, R. E., Pless, Stephan, Schwarz, S. K. W. & Ahern, C. A., 1 Jan 2013, In: Channels (Austin). 7, 1, p. 47-50 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Extracellular quaternary ammonium blockade of transient receptor potential vanilloid subtype 1 channels expressed in Xenopus laevis oocytes

    Rivera-Acevedo, R. E., Pless, Stephan, Schwarz, S. K. W. & Ahern, C. A., Dec 2012, In: Molecular Pharmacology. 82, 6, p. 1129-35 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener

    Wang, A. W., Yau, M. C., Wang, C. K., Sharmin, N., Yang, R. Y., Pless, Stephan & Kurata, H. T., 30 Aug 2018, In: Journal of General Physiology. 150, 10, p. 1432-1443 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Functional Characterization of Disease-Causing Mutations in the Sodium Leak Channel NALCN

    wbv551, wbv551, Ameen, A. O., Chua, H. C. & Pless, Stephan, 2021, p. 10A-11A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  32. Published

    Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5

    Galleano, I., Harms, Hendrik, Choudhury, K., Khoo, K., Delemotte, L. & Pless, Stephan, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 33, 10 p., e2025320118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Functional modulation of a pH-sensitive ion channel by a transporter family

    Poulsen, Mette Homann, Xue, F., Maurya, S. R., Kickinger, Stefanie, Usher, Samuel George, Wellendorph, Petrine, Lundby, Alicia & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 249a

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  34. Published

    High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics

    Wulf, M. & Pless, Stephan, 6 Feb 2018, In: Cell Reports. 22, 6, p. 1615-1626 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology

    Braun, N., Friis, S., Ihling, C., Sinz, A., Andersen, J. & Pless, Stephan, 2021, In: PLOS Biology. 19, 9, 30 p., e3001321.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    How an intrinsic ligand tunes the activity of a potassium channel

    Khoo, K. K. & Pless, Stephan, 22 Mar 2018, In: Journal of General Physiology. 150, 4, p. 517-520

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  37. Published

    Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels

    Pless, Stephan, Galpin, J. D., Niciforovic, A. P., Kurata, H. T. & Ahern, C. A., 2013, In: eLife. 2, p. e01289

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Illuminating the structure and function of Cys-loop receptors

    Pless, Stephan & Lynch, J. W., Oct 2008, In: Clinical and Experimental Pharmacology & Physiology (Online). 35, 10, p. 1137-42 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Indirect Determinants of Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels

    Sheikh, Zeshan Pervez, Lynagh, T., Kristensen, Anders Skov & Pless, Stephan, 2019, p. 110A-110A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  40. Published

    Inhibitor-Induced Conformational Changes in ASIC1A

    Lund, Camilla, Borg, C. B., Lynagh, T. & Pless, Stephan, 2 Feb 2018, p. 130A-130A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  41. Published

    Intermediate state trapping of a voltage sensor

    Lacroix, J. J., Pless, Stephan, Maragliano, L., Campos, F. V., Galpin, J. D., Ahern, C. A., Roux, B. & Bezanilla, F., Dec 2012, In: Journal of General Physiology. 140, 6, p. 635-52 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Interplay of Nav1.5 Disease-Causing Mutations and Phosphorylation Revealed by Protein Semi-Synthesis and Molecular Dynamics Simulations

    Galleano, I., Harms, Hendrik, Choudhury, K., Khoo, K. K., Delemotte, L. & Pless, Stephan, 2021, p. 288A-288A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  43. Published

    Introduction: Applying Chemical Biology to Ion Channels

    Pless, Stephan & Ahern, C. A., 2015, Applying Chemical Biology to Ion Channels. Vol. 869. p. 1-4 4 p. (Advances in Experimental Medicine and Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  44. Published

    Investigation of Agonist Recognition and Channel Properties in a Flatworm Glutamate-Gated Chloride Channel

    Callau-Vázquez, D., Pless, Stephan & Lynagh, T., 2018, In: Biochemistry. 57, 8, p. 1360-1368

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels

    Sheikh, Zeshan Pervez, Lynagh, T. P. & Pless, Stephan, 2 Feb 2018, p. 24A-24A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  46. Published

    Ion channel engineering using protein trans-splicing

    Sarkar, Debayan, Harms, Hendrik, Galleano, I., Sheikh, Zeshan Pervez & Pless, Stephan, 2021, Methods in Enzymology. Elsevier, p. 19-48 30 p. (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  47. Published

    Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors

    Wang, Q., Pless, Stephan & Lynch, J. W., 17 Dec 2010, In: The Journal of Biological Chemistry. 285, 51, p. 40373-86 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain

    Pless, Stephan & Lynch, J. W., 5 Jun 2009, In: The Journal of Biological Chemistry. 284, 23, p. 15847-56 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy

    Pless, Stephan & Lynch, J. W., 2 Oct 2009, In: The Journal of Biological Chemistry. 284, 40, p. 27370-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Mechanism and Binding Site of the ASIC1A-Big Dynorphin Interaction

    Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedstrom, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 7 Feb 2020, In: Biophysical Journal. 118, 3, supplement 1, p. 582A-582A

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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