Stephanie Heusser
Assistant Professor
Biopharmaceuticals
Jagtvej 162
2100 København Ø
- 2013
- Published
Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels
Heusser, Stephanie, Howard, R. J., Borghese, C. M., Cullins, M. A., Broemstrup, T., Lee, U. S., Lindahl, E., Carlsson, J. & Harris, R. A., Nov 2013, In: Molecular Pharmacology. 84, 5, p. 670-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel
Heusser, Stephanie, Yoluk, Ö., Klement, G., Riederer, E. A., Lindahl, E. & Howard, R. J., Jul 2016, In: Journal of Neurochemistry. 138, 2, p. 243-53 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels
Fourati, Z., Howard, R. J., Heusser, Stephanie, Hu, H., Ruza, R. R., Sauguet, L., Lindahl, E. & Delarue, M., 24 Apr 2018, In: Cell Reports. 23, 4, p. 993-1004 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity
Heusser, Stephanie, Lycksell, M., Wang, X., McComas, S. E., Howard, R. J. & Lindahl, E., 1 Oct 2018, (E-pub ahead of print) In: Proceedings of the National Academy of Sciences of the United States of America. 115, 42, p. 10672-10677Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Mechanism and Binding Site of the ASIC1A-Big Dynorphin Interaction
Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedstrom, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 7 Feb 2020, In: Biophysical Journal. 118, 3, supplement 1, p. 582A-582AResearch output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Mechanism and site of action of big dynorphin on ASIC1a
Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedström, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 13, p. 7447-7454Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Allosteric Gating Determinants in the Transmembrane Domain of Pentameric Ligand-Gated Ion Channels
Howard, R. J., Zhuang, Y., Heusser, Stephanie, Bergh, C. C., Rovsnik, U., Orellana, L. & Lindahl, E., 2020, p. 584A-584A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- 2021
- Published
Conformational Landscapes of Ligand-Gated Ion Channel GLIC from Markov State Modeling
Bergh, C., Heusser, Stephanie, Howard, R. J. & Lindahl, E. R., 2021, p. 58A-58A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel
Bergh, C., Heusser, Stephanie, Howard, R. & Lindahl, E., 2021, In: eLife. 10, 23 p., 68369.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acid-sensing ion channels as potential therapeutic targets
Heusser, Stephanie & Pless, Stephan, 2021, In: Trends in Pharmacological Sciences. 42, 12, p. 1035-1050Research output: Contribution to journal › Review › Research › peer-review
- Published
Characterizing Conformational Changes of ASIC1a During Gating and Peptide Modulation
Heusser, Stephanie, Sheikh, Zeshan Pervez, Borg, C. B., Galleano, I. & Pless, Stephan, 2021, p. 337A-337A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Probing Allosteric Networks in Ligand-Gated Ion Channel Gating by Electrophysiology and Molecular Dynamics in the Model Receptor GLIC
Howard, R. J., Zhuang, Y., Gutheim, S., Zeckey, L., Heusser, Stephanie & Lindahl, E. R., 2021, p. 58A-58A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- 2022
- Published
Conformational decoupling in acidsensing ion channels uncovers mechanism and stoichiometry of PcTx1mediated inhibition
Heusser, Stephanie, Borg, C. B., Colding, J. M. & Pless, Stephan, 2022, In: eLife. 11, 20 p., e73384.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel
Noland, C. L., Chua, H. C., Kschonsak, M., Heusser, Stephanie, Braun, N., Chang, T., Tam, C., Tang, J., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature Communications. 13, 1, 10 p., 1416.Research output: Contribution to journal › Journal article › Research › peer-review
- 2024
- E-pub ahead of print
Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions
Holm, Caroline Marcher, Topaktas, Asli Bahar, Dannesboe, Johs, Pless, Stephan & Heusser, Stephanie, 2024, (E-pub ahead of print) In: Biophysical Journal.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels
Sarkar, Debayan, Galleano, I., Heusser, Stephanie, Ou, S. Y., Uzun, G. R., Khoo, K. K., van der Heden van Noort, G. J., Harrison, J. S. & Pless, Stephan, 2024, (Accepted/In press) In: Cell Chemical Biology.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 203075805
Most downloads
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21
downloads
Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels
Research output: Contribution to journal › Journal article › Research › peer-review
-
14
downloads
Conformational decoupling in acidsensing ion channels uncovers mechanism and stoichiometry of PcTx1mediated inhibition
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
11
downloads
Characterizing Conformational Changes of ASIC1a During Gating and Peptide Modulation
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published