Stephanie Heusser

Stephanie Heusser

Assistant Professor


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  1. Accepted/In press

    Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels

    Sarkar, Debayan, Galleano, I., Heusser, Stephanie, Ou, S. Y., Uzun, G. R., Khoo, K. K., van der Heden van Noort, G. J., Harrison, J. S. & Pless, Stephan, 2024, (Accepted/In press) In: Cell Chemical Biology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

    Noland, C. L., Chua, H. C., Kschonsak, M., Heusser, Stephanie, Braun, N., Chang, T., Tam, C., Tang, J., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature Communications. 13, 1, 10 p., 1416.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Probing Allosteric Networks in Ligand-Gated Ion Channel Gating by Electrophysiology and Molecular Dynamics in the Model Receptor GLIC

    Howard, R. J., Zhuang, Y., Gutheim, S., Zeckey, L., Heusser, Stephanie & Lindahl, E. R., 2021, p. 58A-58A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  4. Published

    Allosteric Gating Determinants in the Transmembrane Domain of Pentameric Ligand-Gated Ion Channels

    Howard, R. J., Zhuang, Y., Heusser, Stephanie, Bergh, C. C., Rovsnik, U., Orellana, L. & Lindahl, E., 2020, p. 584A-584A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  5. E-pub ahead of print

    Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions

    Holm, Caroline Marcher, Topaktas, Asli Bahar, Dannesboe, Johs, Pless, Stephan & Heusser, Stephanie, 2024, (E-pub ahead of print) In: Biophysical Journal.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Conformational decoupling in acidsensing ion channels uncovers mechanism and stoichiometry of PcTx1mediated inhibition

    Heusser, Stephanie, Borg, C. B., Colding, J. M. & Pless, Stephan, 2022, In: eLife. 11, 20 p., e73384.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Characterizing Conformational Changes of ASIC1a During Gating and Peptide Modulation

    Heusser, Stephanie, Sheikh, Zeshan Pervez, Borg, C. B., Galleano, I. & Pless, Stephan, 2021, p. 337A-337A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  8. Published

    Acid-sensing ion channels as potential therapeutic targets

    Heusser, Stephanie & Pless, Stephan, 2021, In: Trends in Pharmacological Sciences. 42, 12, p. 1035-1050

    Research output: Contribution to journal › Review › Research › peer-review

  9. Published

    Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels

    Heusser, Stephanie, Howard, R. J., Borghese, C. M., Cullins, M. A., Broemstrup, T., Lee, U. S., Lindahl, E., Carlsson, J. & Harris, R. A., Nov 2013, In: Molecular Pharmacology. 84, 5, p. 670-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity

    Heusser, Stephanie, Lycksell, M., Wang, X., McComas, S. E., Howard, R. J. & Lindahl, E., 1 Oct 2018, (E-pub ahead of print) In: Proceedings of the National Academy of Sciences of the United States of America. 115, 42, p. 10672-10677

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 203075805