Trond Ulven
Professor
- 2011
Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3
Schmidt, J., Smith, N. J., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Hudson, B. D., Ward, R. J., Drewke, C., Milligan, G., Kostenis, E. & Ulven, Trond, 10 Jan 2011, In: Journal of Biological Chemistry. 286, 12, p. 10628-10640 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Method of synthesizing a 5-oxo-conjugated fatty acid
Ulven, Trond & Tyagi, R., 27 Oct 2011, Patent No. WO 2011/131619 A1Research output: Patent
- 2012
- Published
A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer
Blättermann, S., Peters, L., Ottersbach, P. A., Bock, A., Konya, V., Weaver, C. D., Gonzalez, A., Schröder, R., Tyagi, R., Luschnig, P., Gäb, J., Hennen, S., Ulven, Trond, Pardo, L., Mohr, K., Gütschow, M., Heinemann, A. & Kostenis, E., 2012, In: Nature Chemical Biology. 8, 7, p. 631-638 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A concise synthesis of the potent inflammatory mediator 5-oxo-ETE
Tyagi, R., Shimpukade, B., Blättermann, S., Kostenis, E. & Ulven, Trond, 2012, In: MedChemComm. 3, p. 195-198 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs
Hudson, B. D., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, Trond & Milligan, G., 2012, In: F A S E B Journal. 26, 12, p. 4951-4965 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of a potent and selective GPR120 agonist
Shimpukade, B., Hudson, B. D., Hovgaard, C. K., Milligan, G. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 9, p. 4511-4515 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3
Hudson, B. D., Tikhonova, I. G., Pandey, S. K., Ulven, Trond & Milligan, G., 2012, In: Journal of Biological Chemistry. 287, 49, p. 41195-41209 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists
Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schröder, R., Hudson, B. D., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 14, p. 6624-6628 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2
Schröder, R., Xue, L., Konya, V., Martini, L., Kampitsch, N., Whistler, J. L., Ulven, Trond, Heinemann, A., Pettipher, R. & Kostenis, E., 2012, In: P L o S One. 7, 3, p. e33329Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets
Ulven, Trond, 2012, In: Frontiers in Endocrinology. 3Research output: Contribution to journal › Journal article › Research › peer-review
ID: 187375453
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Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
109
downloads
Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
108
downloads
Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum
Research output: Contribution to journal › Journal article › Research › peer-review
Published