Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists
Research output: Contribution to journal › Journal article › Research › peer-review
FFA1 (GPR40) is a new target for treatment of type 2 diabetes. We recently identified the potent FFA1 agonist TUG-469 (5). Inspired by the structurally related TAK-875, we explored the effects of a mesylpropoxy appendage on 5. The appendage significantly lowers lipophilicity and improves metabolic stability while preserving potency, resulting in discovery of the potent FFA1 agonist 13.
| Original language | English |
|---|---|
| Journal | Journal of Medicinal Chemistry |
| Volume | 55 |
| Issue number | 14 |
| Pages (from-to) | 6624-6628 |
| Number of pages | 5 |
| ISSN | 0022-2623 |
| DOIs | |
| Publication status | Published - 2012 |
| Externally published | Yes |
ID: 189162178