A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

Research output: Contribution to journalJournal articleResearchpeer-review

  • Rahul Tyagi
  • Bharat Shimpukade
  • Stefanie Blättermann
  • Evi Kostenis
  • Ulven, Trond
A concise and practical method for synthesis of the potent inflammatory mediator 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE, 1) from arachidonic acid in four steps and 70% overall yield is reported. Stability studies indicate that 1 can be safely handled without rigorous precautions
Original languageEnglish
JournalMedChemComm
Volume3
Pages (from-to)195-198
Number of pages4
ISSN2040-2503
Publication statusPublished - 2012

    Research areas

  • inflammatory mediator, 5-oxo-ETE

ID: 189158850