Uffe Kristiansen
Associate Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- 1991
- Published
4-PIOL, a low-efficacy partial GABA-A agonist
Frølund, Bente, Kristiansen, Uffe, Nathan, T., Falch, E., Lambert, J. D. C. & Krogsgaard-Larsen, Povl, 1991, Drug Research related to Neuroactive Amino Acids. MunksgaardResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Novel (Gamma-Aminobutyric Acid)A Agonists and Partial Agonists
Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe, Lambert, J. D. C., Falch, E. & Curtis, D. R., 1991, Transmitter Amino Acid Receptors. Barnard, E. A. & Costa, E. (eds.). Raven Press, p. 237–249Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Ligand Structural Specificity of GABAA Receptors in Guinea Pig Ileum
Kristiansen, Uffe & Fjalland, B., May 1991, In: Pharmacology & Toxicology. 68, 5, p. 332-339 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Electrophysiological studies of the GABAA receptor ligand, 4‐PIOL, on cultured hippocampal neurones
Kristiansen, Uffe, Lambert, J. D. C., Falch, E. & Krogsgaard-Larsen, Povl, Sep 1991, In: British Journal of Pharmacology. 104, 1, p. 85-90 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1992
- Published
Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships
Kristiansen, Uffe, bjl587, bjl587, Herdeis, C., Lund, Trine Meldgaard, Nielsen, Birgitte, Hansen, J. J., Falch, E., Hjeds, H. & Krogsgaard-Larsen, Povl, Mar 1992, In: Journal of Neurochemistry. 58, 3, p. 1150-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
- Published
GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer
Frydenvang, Karla Andrea, Kristiansen, Uffe, Frølund, Bente, Herdeis, C. & Krogsgaard-Larsen, Povl, 1995, In: Chirality. 7, p. 526–533Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Partial GABAA Receptor agonists. Synthesis and in vitro Pharmacology
Frølund, Bente, Kristiansen, Uffe, Brehm, L., Hansen, A. B., Krogsgaard-Larsen, Povl & Falch, E., 1995, In: Journal of Medicinal Chemistry. 38, p. 3287–3296Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The low efficacy γ-aminobutyric acid type A agonist 5-(4- piperidyl)isoxazol-3-ol opens brief Cl- channels in embryonic rat olfactory bulb neurons
Kristiansen, Uffe, Barker, J. L. & Serafini, R., 1995, In: Molecular Pharmacology. 48, 2, p. 268-279 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Partial GABAA Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol
Frølund, Bente, Kristiansen, Uffe, Brehm, L., Hansen, A. B., Krogsgaard-Larsen, Povl & Falch, E., 1 Aug 1995, In: Journal of Medicinal Chemistry. 38, 17, p. 3287-3296 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
- Published
Benzodiazepine and barbiturate ligands modulate responses of cultured hippocampal neurones to the GABA(A) receptor partial agonist, 4-PIOL
Kristiansen, Uffe & Lambert, J. D. C., 1996, In: Neuropharmacology. 35, 9-10, p. 1181-1191 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stereospecific GABA-B receptor antagonism
Frydenvang, Karla Andrea, Frølund, Bente, Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 1996, GABA, receptors, transporters and metabolism. Tanaka, C. & Bowery, N. G. (eds.). Basel: Birkhäuser VerlagResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 1997
- Published
GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects
Frølund, Bente, Krogsgaard-Larsen, Povl, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., 1997, In: European Journal of Pharmaceutical Sciences. 4, p. 355–384Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABA(A) receptors
Brehm, L., Ebert, B., Kristiansen, Uffe, Wafford, K. A., Kemp, J. A. & Krogsgaard-Larsen, Povl, 1997, In: European Journal of Medicinal Chemistry. 32, 4, p. 357-363 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA(A) and GABA(B) receptor agonists, partial agonists, antagonists and modulators: Design and therapeutic prospects
Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., Nov 1997, In: European Journal of Pharmaceutical Sciences. 5, 6, p. 355-384 30 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
Functional properties of glycine receptors expressed in primary cultures of mouse cerebellar granule cells
Elster, L., Banke, T., Kristiansen, Uffe, Schousboe, Arne & Wahl, P., May 1998, In: Neuroscience. 84, 2, p. 519-28 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
A Novel Class of Potent 3-Isoxazolol GABAA Antagonists: Design, Synthesis, and Pharmacology
Frølund, Bente, Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 2000, In: Journal of Medicinal Chemistry. 43, p. 4930–4933Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A single glycine residue at the entrance to the first membrane-spanning domain of the γ-aminobutyric acid type a receptor β2 subunit affects allosteric sensitivity to GABA and anesthetics
Carlson, B. X., Engblom, A. C., Kristiansen, Uffe, Schousboe, Arne & Olsen, R. W., 2000, In: Molecular Pharmacology. 57, 3, p. 474-484 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel class of potent 3-isoxazolol GABAA antagonists: Design, systhesis, and pharmacology [3]
Frølund, Bente, Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 28 Dec 2000, In: Journal of Medicinal Chemistry. 43, 26, p. 4930-4933 4 p.Research output: Contribution to journal › Letter › Research › peer-review
- 2001
- Published
Effects of GABAA receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions
Hansen, S. L., Ebert, B., Fjalland, B. & Kristiansen, Uffe, 2001, In: British Journal of Pharmacology. 133, 4, p. 539-549 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular determinants of desensitization and assembly of the chimeric GABA(A) receptor subunits (alpha1/gamma2) and (gamma2/alpha1) in combinations with beta2 and gamma2
Elster, L., Kristiansen, Uffe, Pickering, Darryl S, Olsen, R. W. & Schousboe, Arne, 2001, In: Neurochemistry International. 38, 7, p. 581-92 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligands for the GABAA receptor complex
Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe & Ebert, B., 1 Jan 2001, Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. CRC Press, p. 236-274 39 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2002
- Published
GABAA receptor ligands and their therapeutic potentials
Frølund, Bente, Ebert, B., Kristiansen, Uffe, Liljefors, T. & Krogsgaard-Larsen, Povl, 2002, In: Current Topics in Medicinal Chemistry. 2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligands for the GABAA receptor complex
Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe & Ebert, B., 2002, Glutamate and GABA receptors of AMPA/kainate receptors and transporters. Taylor & Francis, p. 236–274Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Novel Class of Potent 4-Arylalkyl Substituted 3-Isoxazolol GABAA Antagonists:Synthesis, Pharmacology, and Molecular Modeling
Frølund, Bente, Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, Uffe, Sanchez, C., Krogsgaard-Larsen, Povl & Liljefors, T., 2002, In: Journal of Medicinal Chemistry. 45, p. 2454–2468Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Point mutation in the first transmembrane region of the β2 subunit of the γ-aminobutyric acid type A receptor alters desensitization kinetics of γ-aminobutyric acid- and anesthetic-induced channel gating
Christine Engblom, A., Carlson, B. X., Olsen, R. W., Schousboe, Arne & Kristiansen, Uffe, 17 May 2002, In: Journal of Biological Chemistry. 277, 20, p. 17438-17447 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABAA antagonists: Synthesis, pharmacology, and molecular modeling
Frølund, Bente, Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, Uffe, Sanchez, C., Krogsgaard-Larsen, Povl & Liljefors, T., 6 Jun 2002, In: Journal of Medicinal Chemistry. 45, 12, p. 2454-2468 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA(A) receptor ligands and their therapeutic potentials.
Frølund, Bente, Ebert, B., Kristiansen, Uffe, Liljefors, T. & Krogsgaard-Larsen, Povl, Aug 2002, In: Current Topics in Medicinal Chemistry. 2, 8, p. 817-832 16 p.Research output: Contribution to journal › Review › Research › peer-review
- 2003
- Published
Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABAA antagonists
Frølund, Bente, Tagmose, L., Jørgensen, A. T., Kristiansen, Uffe, Stensbøl, T. B., Liljefors, T. & Krogsgaard-Larsen, Povl, 2003, In: European Journal of Medicinal Chemistry. 38, p. 447–449Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABAA antagonists
Frølund, Bente, Tagmose, L., Jørgensen, A. T., Kristiansen, Uffe, Stensbøl, T. B., Liljefors, T. & Krogsgaard-Larsen, Povl, 1 Apr 2003, In: European Journal of Medicinal Chemistry. 38, 4, p. 447-449 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Activation on single heteromeric GABAA receptor Ion channels by full and partial agonists
Mortensen, M., Kristiansen, Uffe, Ebert, B., Frølund, Bente, Krogsgaard-Larsen, Povl & Smart, T., 2004, In: Journal of Physiology. p. 393–417Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay
Jensen, Anders A. & Kristiansen, Uffe, 2004, In: Biochemical Pharmacology. 67, 9, p. 1789-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct Optical Detection of Singlet Oxygen from a Single Cell
Zebger, I., Snyder, J. W., Andersen, L. K., Poulsen, L., Gao, Z., Lambert, J. D. C., Kristiansen, Uffe & Ogilby, P. R., Apr 2004, In: Photochemistry and Photobiology. 79, 4, p. 319-322 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of single heteromeric GABAA receptor ion channels by full and partial agonists
Mortensen, M., Kristiansen, Uffe, Ebert, B., Frølund, Bente, Krogsgaard-Larsen, Povl & Smart, T. G., 1 Jun 2004, In: Journal of Physiology. 557, 2, p. 389-413 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABAA antagonists: Synthesis, pharmacology, and molecular modeling
Frølund, Bente, Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, Uffe, Nielsen, Birgitte, Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, Povl & Liljefors, T., 27 Jan 2005, In: Journal of Medicinal Chemistry. 48, 2, p. 427-439 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Effekt og bivirkninger: GABA fra A til C.
Frølund, Bente, Madsen, C., Jensen, Anders A., Kristiansen, Uffe & Liljefors, T., 2006, In: Lægemiddelforskning. p. 32-33Research output: Contribution to journal › Journal article › Communication
- Published
Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds
Lolli, M. L., Hansen, S. L., Rolando, B., Nielsen, Birgitte, Wellendorph, Petrine, Madsen, K., Larsen, O. M., Kristiansen, Uffe, Fruttero, R., Gasco, A. & Johansen, Tommy Nørskov, 2006, In: J. Med. Chem.. 49, p. 4442-4446 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
5-Substituted imidazole-4-acetic acid analogues: Synthesis, modeling, and pharmacological characterization of a series of novel γ-aminobutyric acidC receptor agonists
Madsen, C., Jensen, Anders A., Liljefors, T., Kristiansen, Uffe, Nielsen, Birgitte, Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, Povl & Frølund, Bente, 2007, In: Journal of Medicinal Chemistry. 50, p. 4147-4161Research output: Contribution to journal › Journal article › Research › peer-review
- Published
5-substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel ¿-aminobutyric acidC receptor agonists
Madsen, C., Jensen, A. A., Liljefors, T., Kristiansen, Uffe, Nielsen, Birgitte, Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, Povl & Frølund, Bente, 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4147-4161Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differences in kinetics of structurally related competitive GABAA receptor antagonists
Vestergaard, H. T., Cannillo, C., Frølund, Bente & Kristiansen, Uffe, 2007, In: Neuropharmacology. 52, 3, p. 873-882Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing the pharmacophore of ginkgolides as glycine receptor antagonists
Jensen, Anders A., Begum, N., Vogensen, S. B., Knapp, K. M., Gundertofte, K., Dzyuba, S. V., Ishii, H., Nakanishi, K., Kristiansen, Uffe & Strømgaard, Kristian, 2007, In: Journal of Medicinal Chemistry. 50, 7, p. 1610-1617Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Effect of acute injections of the ketone bodies in PTZ kindled mice
Hansen, S. L., Riisberg, M., Nouri-Nejad, A., Skonberg, C., Kristiansen, Uffe & Hansen, Harald S., 2008.Research output: Contribution to conference › Poster › Research
- Published
Ligands for the GABA recognition site at the GABAA receptor: Structure-activity studies
Frølund, Bente, Kristiansen, Uffe, Krogsgaard-Larsen, Povl & Liljefors, T., 2008, Chemistry and molecular aspects of drug design and action. Rekka, E. A. & Kourounakis, P. N. (eds.). Boca Raton, Fl: CRC Press, p. 139-147Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- 2009
- Published
GABAergic actions on cholinergic laterodorsal tegmental neurons: Implications for control of behavioral state
Kohlmeier, Kristi Anne & Kristiansen, Uffe, 2009, In: Journal of Neuroscience.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus
Hansen, S. L., Nielsen, A. H., Knudsen, K. E., Artmann, A., Kristiansen, Uffe, Hansen, S. H., Hansen, Harald S. & Petersen, G., 2009, In: Neurochemistry International. 54, 3-4, p. 199-204Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Effect of Rhoicissus digitata extracts on acetylcholine-mediated contraction in rat uterus
Schou, J., Kristiansen, Uffe, Stafford, G. I., van Heerden, F. & Jäger, A., Aug 2010, In: Planta Medica. 76, 12, p. 1217Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
GABAergic actions on cholinergic laterodorsal tegmental neurons: implications for control of behavioral state
Kohlmeier, Kristi Anne & Kristiansen, Uffe, 15 Dec 2010, In: Neuroscience. 171, 3, p. 812-29 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Acute but not delayed amphetamine treatment improves behavioral outcome in a rat embolic stroke model
Rasmussen, Rune Skovgaard, Overgaard, K., Kristiansen, Uffe & Johansen, F. F., Sep 2011, In: Neurological Research. 33, 7, p. 774-782 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Uterine contraction induced by Tanzanian plants used to induce abortion
Nikolajsen, T., Nielsen, F., Rasch, V., Sørensen, P. H., Ismail, F., Kristiansen, Uffe & Jäger, A. K., 1 Sep 2011, In: Journal of Ethnopharmacology. 137, 1, p. 921-925Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Medicinalplanter og abort: ny viden kan hjælpe afrikanske kvinder
Jäger, A., Kristiansen, Uffe & Rasch, V., Dec 2011, In: Lægemiddelforskning. 2011, p. 23-25Research output: Contribution to journal › Journal article › Communication
- 2012
- Published
Does brain slices from pentylenetetrazole-kindled mice provide a more predictive screening model for antiepileptic drugs?
Hansen, S. L., Sterjev, Z., Werngreen, M., Simonsen, B. J., Knudsen, K. E., Nielsen, A. H., Pedersen, M. E., Badolo, L., Kristiansen, Uffe & Vestergaard, H. T., May 2012, In: European Journal of Pharmacology. 682, 1-3, p. 43-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 985515
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Increasing cellular lifespan with a flow system in organotypic culture of the Laterodorsal Tegmentum (LDT)
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Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors
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Astrocytic GABA transporter activity modulates excitatory neurotransmission
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