A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists

Research output: Contribution to journal › Journal article › Research › peer-review

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A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists. / Christiansen, Elisabeth; Due-Hansen, Maria E; Ulven, Trond.

In: Journal of Organic Chemistry, Vol. 75, No. 4, 19.02.2010, p. 1301-1304.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Christiansen, E, Due-Hansen, ME & Ulven, T 2010, 'A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists', Journal of Organic Chemistry, vol. 75, no. 4, pp. 1301-1304. https://doi.org/10.1021/jo902533p

APA

Christiansen, E., Due-Hansen, M. E., & Ulven, T. (2010). A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists. Journal of Organic Chemistry, 75(4), 1301-1304. https://doi.org/10.1021/jo902533p

Vancouver

Christiansen E, Due-Hansen ME, Ulven T. A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists. Journal of Organic Chemistry. 2010 Feb 19;75(4):1301-1304. https://doi.org/10.1021/jo902533p

Author

Christiansen, Elisabeth ; Due-Hansen, Maria E ; Ulven, Trond. / A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists. In: Journal of Organic Chemistry. 2010 ; Vol. 75, No. 4. pp. 1301-1304.

Bibtex

@article{9081d783f530479ea6499156f1d25b75,
title = "A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists",
abstract = "A protocol for rapid and efficient Pd/Cu-catalyzed coupling of aryl bromides and iodides to terminal alkynes has been developed with use of 2-(di-tert-butylphosphino)-N-phenylindole (cataCXium PIntB) as ligand in TMEDA and water. The new protocol successfully couples substrates which failed with standard Sonogashira conditions, and enables an efficient general synthetic route to free fatty acid 1 (FFA1) receptor ligands from 3-(4-bromophenyl)propionic acid.",
author = "Elisabeth Christiansen and Due-Hansen, {Maria E} and Trond Ulven",
year = "2010",
month = feb,
day = "19",
doi = "10.1021/jo902533p",
language = "English",
volume = "75",
pages = "1301--1304",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "4",

}

RIS

TY - JOUR

T1 - A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists

AU - Christiansen, Elisabeth

AU - Due-Hansen, Maria E

AU - Ulven, Trond

PY - 2010/2/19

Y1 - 2010/2/19

N2 - A protocol for rapid and efficient Pd/Cu-catalyzed coupling of aryl bromides and iodides to terminal alkynes has been developed with use of 2-(di-tert-butylphosphino)-N-phenylindole (cataCXium PIntB) as ligand in TMEDA and water. The new protocol successfully couples substrates which failed with standard Sonogashira conditions, and enables an efficient general synthetic route to free fatty acid 1 (FFA1) receptor ligands from 3-(4-bromophenyl)propionic acid.

AB - A protocol for rapid and efficient Pd/Cu-catalyzed coupling of aryl bromides and iodides to terminal alkynes has been developed with use of 2-(di-tert-butylphosphino)-N-phenylindole (cataCXium PIntB) as ligand in TMEDA and water. The new protocol successfully couples substrates which failed with standard Sonogashira conditions, and enables an efficient general synthetic route to free fatty acid 1 (FFA1) receptor ligands from 3-(4-bromophenyl)propionic acid.

U2 - 10.1021/jo902533p

DO - 10.1021/jo902533p

M3 - Journal article

VL - 75

SP - 1301

EP - 1304

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 4

ER -

ID: 189162076