A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists
Research output: Contribution to journal › Journal article › Research › peer-review
A protocol for rapid and efficient Pd/Cu-catalyzed coupling of aryl bromides and iodides to terminal alkynes has been developed with use of 2-(di-tert-butylphosphino)-N-phenylindole (cataCXium PIntB) as ligand in TMEDA and water. The new protocol successfully couples substrates which failed with standard Sonogashira conditions, and enables an efficient general synthetic route to free fatty acid 1 (FFA1) receptor ligands from 3-(4-bromophenyl)propionic acid.
Original language | English |
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Journal | Journal of Organic Chemistry |
Volume | 75 |
Issue number | 4 |
Pages (from-to) | 1301-1304 |
Number of pages | 4 |
ISSN | 0022-3263 |
DOIs | |
Publication status | Published - 19 Feb 2010 |
Externally published | Yes |
ID: 189162076