Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan
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Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan. / Jeppesen, Anne S.; Kristiansen, Uffe; Soelberg, Jens; Jäger, Anna K.
In: Journal of Ethnopharmacology, Vol. 141, No. 3, 14.06.2012, p. 1077-1079.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan
AU - Jeppesen, Anne S.
AU - Kristiansen, Uffe
AU - Soelberg, Jens
AU - Jäger, Anna K.
PY - 2012/6/14
Y1 - 2012/6/14
N2 - Ethnopharmacological relevance: The roots of Rubia tibetica are chewed as an antidote to anaphylaxis caused by bites of the tick Ornithodoros lahorensis by the Wakhi people in Afghanistan. Aims of the study: To test whether Rubia tibetica possess anti-histamine effect. Materials and methods: Water and ethanol extracts of roots of Rubia tibetica were tested for anti-histamine effect on the H 1-receptor in the guinea pig ileum assay. Fixed concentrations of plant extract with increasing concentrations of histamine were examined. Mepyramine was used as control. Results and conclusion: The ethanol extract of Rubia tibetica showed dose-dependent anti-histamine effect, whereas the water extract had little activity. The chewing of Rubia tibetica roots may alleviate the fatal swelling of the tongue during anaphylaxis.
AB - Ethnopharmacological relevance: The roots of Rubia tibetica are chewed as an antidote to anaphylaxis caused by bites of the tick Ornithodoros lahorensis by the Wakhi people in Afghanistan. Aims of the study: To test whether Rubia tibetica possess anti-histamine effect. Materials and methods: Water and ethanol extracts of roots of Rubia tibetica were tested for anti-histamine effect on the H 1-receptor in the guinea pig ileum assay. Fixed concentrations of plant extract with increasing concentrations of histamine were examined. Mepyramine was used as control. Results and conclusion: The ethanol extract of Rubia tibetica showed dose-dependent anti-histamine effect, whereas the water extract had little activity. The chewing of Rubia tibetica roots may alleviate the fatal swelling of the tongue during anaphylaxis.
KW - Anaphylaxis
KW - Guinea pig ileum
KW - Histamine
KW - Ornithodoros lahorensis
KW - Pamir
KW - Rubia tibetica
KW - Tick
KW - Wakhan
UR - http://www.scopus.com/inward/record.url?scp=84861334214&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2012.03.035
DO - 10.1016/j.jep.2012.03.035
M3 - Letter
AN - SCOPUS:84861334214
VL - 141
SP - 1077
EP - 1079
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
SN - 0378-8741
IS - 3
ER -
ID: 182509796