Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan

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Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan. / Jeppesen, Anne S.; Kristiansen, Uffe; Soelberg, Jens; Jäger, Anna K.

In: Journal of Ethnopharmacology, Vol. 141, No. 3, 14.06.2012, p. 1077-1079.

Research output: Contribution to journal › Letter › Research › peer-review

Harvard

Jeppesen, AS, Kristiansen, U, Soelberg, J & Jäger, AK 2012, 'Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan', Journal of Ethnopharmacology, vol. 141, no. 3, pp. 1077-1079. https://doi.org/10.1016/j.jep.2012.03.035

APA

Jeppesen, A. S., Kristiansen, U., Soelberg, J., & Jäger, A. K. (2012). Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan. Journal of Ethnopharmacology, 141(3), 1077-1079. https://doi.org/10.1016/j.jep.2012.03.035

Vancouver

Jeppesen AS, Kristiansen U, Soelberg J, Jäger AK. Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan. Journal of Ethnopharmacology. 2012 Jun 14;141(3):1077-1079. https://doi.org/10.1016/j.jep.2012.03.035

Author

Jeppesen, Anne S. ; Kristiansen, Uffe ; Soelberg, Jens ; Jäger, Anna K. / Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan. In: Journal of Ethnopharmacology. 2012 ; Vol. 141, No. 3. pp. 1077-1079.

Bibtex

@article{da8448e1b1bf48178fd9da06faceb766,
title = "Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan",
abstract = "Ethnopharmacological relevance: The roots of Rubia tibetica are chewed as an antidote to anaphylaxis caused by bites of the tick Ornithodoros lahorensis by the Wakhi people in Afghanistan. Aims of the study: To test whether Rubia tibetica possess anti-histamine effect. Materials and methods: Water and ethanol extracts of roots of Rubia tibetica were tested for anti-histamine effect on the H 1-receptor in the guinea pig ileum assay. Fixed concentrations of plant extract with increasing concentrations of histamine were examined. Mepyramine was used as control. Results and conclusion: The ethanol extract of Rubia tibetica showed dose-dependent anti-histamine effect, whereas the water extract had little activity. The chewing of Rubia tibetica roots may alleviate the fatal swelling of the tongue during anaphylaxis.",
keywords = "Anaphylaxis, Guinea pig ileum, Histamine, Ornithodoros lahorensis, Pamir, Rubia tibetica, Tick, Wakhan",
author = "Jeppesen, {Anne S.} and Uffe Kristiansen and Jens Soelberg and J{\"a}ger, {Anna K.}",
year = "2012",
month = jun,
day = "14",
doi = "10.1016/j.jep.2012.03.035",
language = "English",
volume = "141",
pages = "1077--1079",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan

AU - Jeppesen, Anne S.

AU - Kristiansen, Uffe

AU - Soelberg, Jens

AU - Jäger, Anna K.

PY - 2012/6/14

Y1 - 2012/6/14

N2 - Ethnopharmacological relevance: The roots of Rubia tibetica are chewed as an antidote to anaphylaxis caused by bites of the tick Ornithodoros lahorensis by the Wakhi people in Afghanistan. Aims of the study: To test whether Rubia tibetica possess anti-histamine effect. Materials and methods: Water and ethanol extracts of roots of Rubia tibetica were tested for anti-histamine effect on the H 1-receptor in the guinea pig ileum assay. Fixed concentrations of plant extract with increasing concentrations of histamine were examined. Mepyramine was used as control. Results and conclusion: The ethanol extract of Rubia tibetica showed dose-dependent anti-histamine effect, whereas the water extract had little activity. The chewing of Rubia tibetica roots may alleviate the fatal swelling of the tongue during anaphylaxis.

AB - Ethnopharmacological relevance: The roots of Rubia tibetica are chewed as an antidote to anaphylaxis caused by bites of the tick Ornithodoros lahorensis by the Wakhi people in Afghanistan. Aims of the study: To test whether Rubia tibetica possess anti-histamine effect. Materials and methods: Water and ethanol extracts of roots of Rubia tibetica were tested for anti-histamine effect on the H 1-receptor in the guinea pig ileum assay. Fixed concentrations of plant extract with increasing concentrations of histamine were examined. Mepyramine was used as control. Results and conclusion: The ethanol extract of Rubia tibetica showed dose-dependent anti-histamine effect, whereas the water extract had little activity. The chewing of Rubia tibetica roots may alleviate the fatal swelling of the tongue during anaphylaxis.

KW - Anaphylaxis

KW - Guinea pig ileum

KW - Histamine

KW - Ornithodoros lahorensis

KW - Pamir

KW - Rubia tibetica

KW - Tick

KW - Wakhan

UR - http://www.scopus.com/inward/record.url?scp=84861334214&partnerID=8YFLogxK

U2 - 10.1016/j.jep.2012.03.035

DO - 10.1016/j.jep.2012.03.035

M3 - Letter

AN - SCOPUS:84861334214

VL - 141

SP - 1077

EP - 1079

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 3

ER -

ID: 182509796