Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds. / Thanh Tung, Truong; Christensen, Søren Brøgger; Nielsen, John.

In: Chemistry: A European Journal, Vol. 23, 11.10.2017, p. 18125-18128.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thanh Tung, T, Christensen, SB & Nielsen, J 2017, 'Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds', Chemistry: A European Journal, vol. 23, pp. 18125-18128. https://doi.org/10.1002/chem.201704261

APA

Thanh Tung, T., Christensen, S. B., & Nielsen, J. (2017). Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds. Chemistry: A European Journal, 23, 18125-18128. https://doi.org/10.1002/chem.201704261

Vancouver

Thanh Tung T, Christensen SB, Nielsen J. Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds. Chemistry: A European Journal. 2017 Oct 11;23:18125-18128. https://doi.org/10.1002/chem.201704261

Author

Thanh Tung, Truong ; Christensen, Søren Brøgger ; Nielsen, John. / Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds. In: Chemistry: A European Journal. 2017 ; Vol. 23. pp. 18125-18128.

Bibtex

@article{2e8d8366aa3d4404bca6dbe7ba70a545,
title = "Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds",
abstract = "A technically simple procedure for direct C-H difluoromethylation of heteroaromatic compounds using off-the-shelf difluoroacetic acid as the difluoromethylating reagent has been developed. Mono-difluoromethylation versus bis-difluoromethylation is controlled as the result of the reaction temperature. The reactions described here enable access to the late-stage C-H mono- and bis-difluoromethylation for preparation of tool compounds for chemical biology and provide access to this hitherto untapped substituent for drug discovery.",
keywords = "Journal Article",
author = "{Thanh Tung}, Truong and Christensen, {S{\o}ren Br{\o}gger} and John Nielsen",
note = "{\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2017",
month = oct,
day = "11",
doi = "10.1002/chem.201704261",
language = "English",
volume = "23",
pages = "18125--18128",
journal = "Chemistry: A European Journal",
issn = "0947-6539",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",

}

RIS

TY - JOUR

T1 - Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds

AU - Thanh Tung, Truong

AU - Christensen, Søren Brøgger

AU - Nielsen, John

N1 - © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2017/10/11

Y1 - 2017/10/11

N2 - A technically simple procedure for direct C-H difluoromethylation of heteroaromatic compounds using off-the-shelf difluoroacetic acid as the difluoromethylating reagent has been developed. Mono-difluoromethylation versus bis-difluoromethylation is controlled as the result of the reaction temperature. The reactions described here enable access to the late-stage C-H mono- and bis-difluoromethylation for preparation of tool compounds for chemical biology and provide access to this hitherto untapped substituent for drug discovery.

AB - A technically simple procedure for direct C-H difluoromethylation of heteroaromatic compounds using off-the-shelf difluoroacetic acid as the difluoromethylating reagent has been developed. Mono-difluoromethylation versus bis-difluoromethylation is controlled as the result of the reaction temperature. The reactions described here enable access to the late-stage C-H mono- and bis-difluoromethylation for preparation of tool compounds for chemical biology and provide access to this hitherto untapped substituent for drug discovery.

KW - Journal Article

U2 - 10.1002/chem.201704261

DO - 10.1002/chem.201704261

M3 - Journal article

C2 - 28945302

VL - 23

SP - 18125

EP - 18128

JO - Chemistry: A European Journal

JF - Chemistry: A European Journal

SN - 0947-6539

ER -

ID: 183760324