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Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes. / Christiansen, Elisabeth; Urban, Christian; Merten, Nicole; Liebscher, Kathrin; Karlsen, Kasper Kannegård; Hamacher, Alexandra; Spinrath, Andreas; Bond, Andrew D; Drewke, Christel; Ullrich, Susanne; Kassack, Matthias U; Kostenis, Evi; Ulven, Trond.
In:
Journal of Medicinal Chemistry, Vol. 51, No. 22, 27.11.2008, p. 7061-4.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Christiansen, E, Urban, C, Merten, N, Liebscher, K, Karlsen, KK, Hamacher, A, Spinrath, A, Bond, AD, Drewke, C, Ullrich, S, Kassack, MU, Kostenis, E
& Ulven, T 2008, '
Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes',
Journal of Medicinal Chemistry, vol. 51, no. 22, pp. 7061-4.
https://doi.org/10.1021/jm8010178
APA
Christiansen, E., Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A. D., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E.
, & Ulven, T. (2008).
Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.
Journal of Medicinal Chemistry,
51(22), 7061-4.
https://doi.org/10.1021/jm8010178
Vancouver
Christiansen E, Urban C, Merten N, Liebscher K, Karlsen KK, Hamacher A et al.
Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.
Journal of Medicinal Chemistry. 2008 Nov 27;51(22):7061-4.
https://doi.org/10.1021/jm8010178
Author
Christiansen, Elisabeth ; Urban, Christian ; Merten, Nicole ; Liebscher, Kathrin ; Karlsen, Kasper Kannegård ; Hamacher, Alexandra ; Spinrath, Andreas ; Bond, Andrew D ; Drewke, Christel ; Ullrich, Susanne ; Kassack, Matthias U ; Kostenis, Evi ; Ulven, Trond. / Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes. In: Journal of Medicinal Chemistry. 2008 ; Vol. 51, No. 22. pp. 7061-4.
Bibtex
@article{283778d42f494d009464c09c6106538f,
title = "Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes",
abstract = "A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA(1)) has been discovered and explored. The preferred compound 20 (TUG-424, EC(50) = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA(1) in metabolic diseases such as diabetes or obesity.",
author = "Elisabeth Christiansen and Christian Urban and Nicole Merten and Kathrin Liebscher and Karlsen, {Kasper Kanneg{\aa}rd} and Alexandra Hamacher and Andreas Spinrath and Bond, {Andrew D} and Christel Drewke and Susanne Ullrich and Kassack, {Matthias U} and Evi Kostenis and Trond Ulven",
year = "2008",
month = nov,
day = "27",
doi = "10.1021/jm8010178",
language = "English",
volume = "51",
pages = "7061--4",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "22",
}
RIS
TY - JOUR
T1 - Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes
AU - Christiansen, Elisabeth
AU - Urban, Christian
AU - Merten, Nicole
AU - Liebscher, Kathrin
AU - Karlsen, Kasper Kannegård
AU - Hamacher, Alexandra
AU - Spinrath, Andreas
AU - Bond, Andrew D
AU - Drewke, Christel
AU - Ullrich, Susanne
AU - Kassack, Matthias U
AU - Kostenis, Evi
AU - Ulven, Trond
PY - 2008/11/27
Y1 - 2008/11/27
N2 - A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA(1)) has been discovered and explored. The preferred compound 20 (TUG-424, EC(50) = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA(1) in metabolic diseases such as diabetes or obesity.
AB - A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA(1)) has been discovered and explored. The preferred compound 20 (TUG-424, EC(50) = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA(1) in metabolic diseases such as diabetes or obesity.
U2 - 10.1021/jm8010178
DO - 10.1021/jm8010178
M3 - Journal article
C2 - 18947221
VL - 51
SP - 7061
EP - 7064
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 22
ER -
