Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes
Research output: Contribution to journal › Journal article › Research › peer-review
A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA(1)) has been discovered and explored. The preferred compound 20 (TUG-424, EC(50) = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA(1) in metabolic diseases such as diabetes or obesity.
| Original language | English |
|---|---|
| Journal | Journal of Medicinal Chemistry |
| Volume | 51 |
| Issue number | 22 |
| Pages (from-to) | 7061-4 |
| Number of pages | 4 |
| ISSN | 0022-2623 |
| DOIs | |
| Publication status | Published - 27 Nov 2008 |
ID: 46275205