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Fragment-based labeling using condensation reactions of six potential 5-HT7R PET tracers. / Tampio L'Estrade, Elina; Shalgunov, Vladimir; Lehel, Szabolcs; Nymann Petersen, Ida; Poulie, Christian Bernard Matthijs; Edgar, Fraser G.; Volk, Balazs; Ohlsson, Tomas; Erlandsson, Maria; Knudsen, Gitte M.; Herth, Matthias M.
In:
Journal of Radioanalytical and Nuclear Chemistry, Vol. 326, 2020, p. 1749-1762.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Tampio L'Estrade, E
, Shalgunov, V, Lehel, S, Nymann Petersen, I
, Poulie, CBM, Edgar, FG, Volk, B, Ohlsson, T, Erlandsson, M
, Knudsen, GM & Herth, MM 2020, '
Fragment-based labeling using condensation reactions of six potential 5-HT7R PET tracers',
Journal of Radioanalytical and Nuclear Chemistry, vol. 326, pp. 1749-1762.
https://doi.org/10.1007/s10967-020-07475-0APA
Tampio L'Estrade, E.
, Shalgunov, V., Lehel, S., Nymann Petersen, I.
, Poulie, C. B. M., Edgar, F. G., Volk, B., Ohlsson, T., Erlandsson, M.
, Knudsen, G. M., & Herth, M. M. (2020).
Fragment-based labeling using condensation reactions of six potential 5-HT7R PET tracers.
Journal of Radioanalytical and Nuclear Chemistry,
326, 1749-1762.
https://doi.org/10.1007/s10967-020-07475-0Vancouver
Tampio L'Estrade E
, Shalgunov V, Lehel S, Nymann Petersen I
, Poulie CBM, Edgar FG et al.
Fragment-based labeling using condensation reactions of six potential 5-HT7R PET tracers.
Journal of Radioanalytical and Nuclear Chemistry. 2020;326:1749-1762.
https://doi.org/10.1007/s10967-020-07475-0Author
Tampio L'Estrade, Elina ; Shalgunov, Vladimir ; Lehel, Szabolcs ; Nymann Petersen, Ida ; Poulie, Christian Bernard Matthijs ; Edgar, Fraser G. ; Volk, Balazs ; Ohlsson, Tomas ; Erlandsson, Maria ; Knudsen, Gitte M. ; Herth, Matthias M. / Fragment-based labeling using condensation reactions of six potential 5-HT7R PET tracers. In: Journal of Radioanalytical and Nuclear Chemistry. 2020 ; Vol. 326. pp. 1749-1762.
Bibtex
@article{e84aca5951734bae83f506daed70bcde,
title = "Fragment-based labeling using condensation reactions of six potential 5-HT7R PET tracers",
abstract = "In this work, a fragment-based labeling procedure was developed based on condensation reactions. Six F-18-labeled (arylpiperazinyl-butyl)oxindole derivatives were synthesized. These structures are interesting lead compounds with respect to development of a 5-HT7R PET tracer. They were radiolabeled in sufficient radiochemical yields, purities and molar activities for future in vivo evaluation in rodents.",
keywords = "Arylpiperazines, Alkylation, Fluorine-18, Carbon-11, Screening, Positron emission tomography, POSITRON-EMISSION-TOMOGRAPHY, IN-VITRO EVALUATION, NO-CARRIER, MEDIATED F-18-FLUORINATION, RECEPTOR ANTAGONIST, F-18, RADIOFLUORINATION, DERIVATIVES, DISCOVERY, LIGANDS",
author = "{Tampio L'Estrade}, Elina and Vladimir Shalgunov and Szabolcs Lehel and {Nymann Petersen}, Ida and Poulie, {Christian Bernard Matthijs} and Edgar, {Fraser G.} and Balazs Volk and Tomas Ohlsson and Maria Erlandsson and Knudsen, {Gitte M.} and Herth, {Matthias M.}",
year = "2020",
doi = "10.1007/s10967-020-07475-0",
language = "English",
volume = "326",
pages = "1749--1762",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
issn = "0236-5731",
publisher = "Akad{\'e}miai Kiad{\'o}",
}
RIS
TY - JOUR
T1 - Fragment-based labeling using condensation reactions of six potential 5-HT7R PET tracers
AU - Tampio L'Estrade, Elina
AU - Shalgunov, Vladimir
AU - Lehel, Szabolcs
AU - Nymann Petersen, Ida
AU - Poulie, Christian Bernard Matthijs
AU - Edgar, Fraser G.
AU - Volk, Balazs
AU - Ohlsson, Tomas
AU - Erlandsson, Maria
AU - Knudsen, Gitte M.
AU - Herth, Matthias M.
PY - 2020
Y1 - 2020
N2 - In this work, a fragment-based labeling procedure was developed based on condensation reactions. Six F-18-labeled (arylpiperazinyl-butyl)oxindole derivatives were synthesized. These structures are interesting lead compounds with respect to development of a 5-HT7R PET tracer. They were radiolabeled in sufficient radiochemical yields, purities and molar activities for future in vivo evaluation in rodents.
AB - In this work, a fragment-based labeling procedure was developed based on condensation reactions. Six F-18-labeled (arylpiperazinyl-butyl)oxindole derivatives were synthesized. These structures are interesting lead compounds with respect to development of a 5-HT7R PET tracer. They were radiolabeled in sufficient radiochemical yields, purities and molar activities for future in vivo evaluation in rodents.
KW - Arylpiperazines
KW - Alkylation
KW - Fluorine-18
KW - Carbon-11
KW - Screening
KW - Positron emission tomography
KW - POSITRON-EMISSION-TOMOGRAPHY
KW - IN-VITRO EVALUATION
KW - NO-CARRIER
KW - MEDIATED F-18-FLUORINATION
KW - RECEPTOR ANTAGONIST
KW - F-18
KW - RADIOFLUORINATION
KW - DERIVATIVES
KW - DISCOVERY
KW - LIGANDS
U2 - 10.1007/s10967-020-07475-0
DO - 10.1007/s10967-020-07475-0
M3 - Journal article
VL - 326
SP - 1749
EP - 1762
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
SN - 0236-5731
ER -
