Standard
Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists. / Christiansen, Elisabeth; Due-Hansen, Maria E; Urban, Christian; Grundmann, Manuel; Schröder, Ralf; Hudson, Brian D; Milligan, Graeme; Cawthorne, Michael A; Kostenis, Evi; Kassack, Matthias U; Ulven, Trond.
In:
Journal of Medicinal Chemistry, Vol. 55, No. 14, 2012, p. 6624-6628.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Christiansen, E, Due-Hansen, ME, Urban, C, Grundmann, M, Schröder, R, Hudson, BD, Milligan, G, Cawthorne, MA, Kostenis, E, Kassack, MU
& Ulven, T 2012, '
Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists',
Journal of Medicinal Chemistry, vol. 55, no. 14, pp. 6624-6628.
https://doi.org/10.1021/jm3002026
APA
Christiansen, E., Due-Hansen, M. E., Urban, C., Grundmann, M., Schröder, R., Hudson, B. D., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U.
, & Ulven, T. (2012).
Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists.
Journal of Medicinal Chemistry,
55(14), 6624-6628.
https://doi.org/10.1021/jm3002026
Vancouver
Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schröder R, Hudson BD et al.
Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists.
Journal of Medicinal Chemistry. 2012;55(14):6624-6628.
https://doi.org/10.1021/jm3002026
Author
Christiansen, Elisabeth ; Due-Hansen, Maria E ; Urban, Christian ; Grundmann, Manuel ; Schröder, Ralf ; Hudson, Brian D ; Milligan, Graeme ; Cawthorne, Michael A ; Kostenis, Evi ; Kassack, Matthias U ; Ulven, Trond. / Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists. In: Journal of Medicinal Chemistry. 2012 ; Vol. 55, No. 14. pp. 6624-6628.
Bibtex
@article{4ac1c40c403d41b69d98af3e50717325,
title = "Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists",
abstract = "FFA1 (GPR40) is a new target for treatment of type 2 diabetes. We recently identified the potent FFA1 agonist TUG-469 (5). Inspired by the structurally related TAK-875, we explored the effects of a mesylpropoxy appendage on 5. The appendage significantly lowers lipophilicity and improves metabolic stability while preserving potency, resulting in discovery of the potent FFA1 agonist 13.",
author = "Elisabeth Christiansen and Due-Hansen, {Maria E} and Christian Urban and Manuel Grundmann and Ralf Schr{\"o}der and Hudson, {Brian D} and Graeme Milligan and Cawthorne, {Michael A} and Evi Kostenis and Kassack, {Matthias U} and Trond Ulven",
year = "2012",
doi = "10.1021/jm3002026",
language = "English",
volume = "55",
pages = "6624--6628",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "14",
}
RIS
TY - JOUR
T1 - Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists
AU - Christiansen, Elisabeth
AU - Due-Hansen, Maria E
AU - Urban, Christian
AU - Grundmann, Manuel
AU - Schröder, Ralf
AU - Hudson, Brian D
AU - Milligan, Graeme
AU - Cawthorne, Michael A
AU - Kostenis, Evi
AU - Kassack, Matthias U
AU - Ulven, Trond
PY - 2012
Y1 - 2012
N2 - FFA1 (GPR40) is a new target for treatment of type 2 diabetes. We recently identified the potent FFA1 agonist TUG-469 (5). Inspired by the structurally related TAK-875, we explored the effects of a mesylpropoxy appendage on 5. The appendage significantly lowers lipophilicity and improves metabolic stability while preserving potency, resulting in discovery of the potent FFA1 agonist 13.
AB - FFA1 (GPR40) is a new target for treatment of type 2 diabetes. We recently identified the potent FFA1 agonist TUG-469 (5). Inspired by the structurally related TAK-875, we explored the effects of a mesylpropoxy appendage on 5. The appendage significantly lowers lipophilicity and improves metabolic stability while preserving potency, resulting in discovery of the potent FFA1 agonist 13.
U2 - 10.1021/jm3002026
DO - 10.1021/jm3002026
M3 - Journal article
VL - 55
SP - 6624
EP - 6628
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 14
ER -
