Ligands for the GABAA receptor complex
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Ligands for the GABAA receptor complex. / Krogsgaard-Larsen, Povl; Frølund, Bente; Kristiansen, Uffe; Ebert, Bjarke.
Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. CRC Press, 2001. p. 236-274.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Ligands for the GABAA receptor complex
AU - Krogsgaard-Larsen, Povl
AU - Frølund, Bente
AU - Kristiansen, Uffe
AU - Ebert, Bjarke
N1 - Publisher Copyright: © 2001 by Taylor & Francis Group, LLC.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The neutral amino acid, 4-aminobutanoic acid (GABA), is an inhibitory transmitter in the central nervous system (CNS). Furthermore, GABA is involved as a neurotransmitter and/or a paracrine effector in the regulation of a variety of physiological mechanisms in the periphery. Some of these latter functions may be under central GABA control, whereas others are managed by local GABA neurons. A large percentage, perhaps the majority, of central neurons are under GABA control. The complex mechanisms underlying the GABA-mediated neurotransmission have been extensively studied using a broad spectrum of electrophysiological, neurochemical, pharmacological, and, in recent years, molecular biological techniques (Curtis and Johnston, 1974; Krnjevic, 1974; Olsen and Venter, 1986; Redburn and Schousboe, 1987; Bowery and Nistico, 1989; Biggio and Costa, 1990; Bowery et al., 1990; Schousboe et al., 1992a; Doble and Martin, 1996; Krogsgaard-Larsen et al., 1997).
AB - The neutral amino acid, 4-aminobutanoic acid (GABA), is an inhibitory transmitter in the central nervous system (CNS). Furthermore, GABA is involved as a neurotransmitter and/or a paracrine effector in the regulation of a variety of physiological mechanisms in the periphery. Some of these latter functions may be under central GABA control, whereas others are managed by local GABA neurons. A large percentage, perhaps the majority, of central neurons are under GABA control. The complex mechanisms underlying the GABA-mediated neurotransmission have been extensively studied using a broad spectrum of electrophysiological, neurochemical, pharmacological, and, in recent years, molecular biological techniques (Curtis and Johnston, 1974; Krnjevic, 1974; Olsen and Venter, 1986; Redburn and Schousboe, 1987; Bowery and Nistico, 1989; Biggio and Costa, 1990; Bowery et al., 1990; Schousboe et al., 1992a; Doble and Martin, 1996; Krogsgaard-Larsen et al., 1997).
UR - http://www.scopus.com/inward/record.url?scp=84862431049&partnerID=8YFLogxK
M3 - Book chapter
AN - SCOPUS:84862431049
SN - 9780748408818
SP - 236
EP - 274
BT - Glutamate and GABA Receptors and Transporters
PB - CRC Press
ER -
ID: 312029340