Role of Histaminergic System in Blood-Brain Barrier Dysfunction Associated with Neurological Disorders
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Role of Histaminergic System in Blood-Brain Barrier Dysfunction Associated with Neurological Disorders. / Bañuelos-Cabrera, Ivette; Valle-Dorado, María Guadalupe; Aldana, Blanca Irene; Orozco-Suárez, Sandra Adela; Rocha, Luisa.
In: Archives of Medical Research, Vol. 45, No. 8, 01.11.2014, p. 677-686.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Role of Histaminergic System in Blood-Brain Barrier Dysfunction Associated with Neurological Disorders
AU - Bañuelos-Cabrera, Ivette
AU - Valle-Dorado, María Guadalupe
AU - Aldana, Blanca Irene
AU - Orozco-Suárez, Sandra Adela
AU - Rocha, Luisa
N1 - Funding Information: We thank Francia Carmona for technical assistance. This study received funding from Consejo Nacional de Ciencia y Tecnología (Grant 220365 and Scholarships 380140 and 232762). Publisher Copyright: © 2015 IMSS.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outside elements from blood to the central nervous system (CNS) that may trigger a cascade of events that leads to neuroinflammation. In this review, evidence that mast cells and the release of factors such as histamine play an important role in the neuroinflammatory process associated with brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy is presented.
AB - Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outside elements from blood to the central nervous system (CNS) that may trigger a cascade of events that leads to neuroinflammation. In this review, evidence that mast cells and the release of factors such as histamine play an important role in the neuroinflammatory process associated with brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy is presented.
KW - Blood-brain barrier
KW - Histamine
KW - Mast cells
KW - Neuroinflammation
KW - Neurological disorders
UR - http://www.scopus.com/inward/record.url?scp=84924812512&partnerID=8YFLogxK
U2 - 10.1016/j.arcmed.2014.11.010
DO - 10.1016/j.arcmed.2014.11.010
M3 - Review
C2 - 25446620
AN - SCOPUS:84924812512
VL - 45
SP - 677
EP - 686
JO - Archives of Medical Research
JF - Archives of Medical Research
SN - 0188-4409
IS - 8
ER -
ID: 346538791