Role of Histaminergic System in Blood-Brain Barrier Dysfunction Associated with Neurological Disorders
Research output: Contribution to journal › Review › Research › peer-review
Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outside elements from blood to the central nervous system (CNS) that may trigger a cascade of events that leads to neuroinflammation. In this review, evidence that mast cells and the release of factors such as histamine play an important role in the neuroinflammatory process associated with brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy is presented.
Original language | English |
---|---|
Journal | Archives of Medical Research |
Volume | 45 |
Issue number | 8 |
Pages (from-to) | 677-686 |
Number of pages | 10 |
ISSN | 0188-4409 |
DOIs | |
Publication status | Published - 1 Nov 2014 |
Bibliographical note
Funding Information:
We thank Francia Carmona for technical assistance. This study received funding from Consejo Nacional de Ciencia y Tecnología (Grant 220365 and Scholarships 380140 and 232762).
Publisher Copyright:
© 2015 IMSS.
- Blood-brain barrier, Histamine, Mast cells, Neuroinflammation, Neurological disorders
Research areas
ID: 346538791