Structural dynamics bridge the gap between the genetic and functional levels of GPCRs

Research output: Contribution to journal › Review › Research › peer-review

Standard

Structural dynamics bridge the gap between the genetic and functional levels of GPCRs. / Torrens-Fontanals, Mariona; Stepniewski, Tomasz M.; Gloriam, David E.; Selent, Jana.

In: Current Opinion in Structural Biology, Vol. 69, 2021, p. 150-159.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Torrens-Fontanals, M, Stepniewski, TM, Gloriam, DE & Selent, J 2021, 'Structural dynamics bridge the gap between the genetic and functional levels of GPCRs', Current Opinion in Structural Biology, vol. 69, pp. 150-159. https://doi.org/10.1016/j.sbi.2021.04.005

APA

Torrens-Fontanals, M., Stepniewski, T. M., Gloriam, D. E., & Selent, J. (2021). Structural dynamics bridge the gap between the genetic and functional levels of GPCRs. Current Opinion in Structural Biology, 69, 150-159. https://doi.org/10.1016/j.sbi.2021.04.005

Vancouver

Torrens-Fontanals M, Stepniewski TM, Gloriam DE, Selent J. Structural dynamics bridge the gap between the genetic and functional levels of GPCRs. Current Opinion in Structural Biology. 2021;69:150-159. https://doi.org/10.1016/j.sbi.2021.04.005

Author

Torrens-Fontanals, Mariona ; Stepniewski, Tomasz M. ; Gloriam, David E. ; Selent, Jana. / Structural dynamics bridge the gap between the genetic and functional levels of GPCRs. In: Current Opinion in Structural Biology. 2021 ; Vol. 69. pp. 150-159.

Bibtex

@article{677c5a8056614be1b352bdad566be5ac,
title = "Structural dynamics bridge the gap between the genetic and functional levels of GPCRs",
abstract = "G protein–coupled receptors (GPCRs) are implicated in nearly all physiological processes in the human body and represent an important drug targeting class. The genes encoding the different GPCR (sub)types determine their specific functionality, which can be altered by natural genetic variants and isoforms. Deciphering the molecular link between sequence diversity and its functional consequences is a current challenge and critical for the comprehension of the physiological response of GPCRs. It requires a global understanding of how protein sequence translates into protein structure, how this impacts the structural motions of the protein, and, finally, how all these factors determine the receptor functionality. Here, we discuss available resources and state-of-the-art computational approaches to address this question.",
keywords = "Computational biology, GPCRs, Receptor signaling, Structural dynamics, Web resources",
author = "Mariona Torrens-Fontanals and Stepniewski, {Tomasz M.} and Gloriam, {David E.} and Jana Selent",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2021",
doi = "10.1016/j.sbi.2021.04.005",
language = "English",
volume = "69",
pages = "150--159",
journal = "Current Opinion in Structural Biology",
issn = "0959-440X",
publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Structural dynamics bridge the gap between the genetic and functional levels of GPCRs

AU - Torrens-Fontanals, Mariona

AU - Stepniewski, Tomasz M.

AU - Gloriam, David E.

AU - Selent, Jana

N1 - Publisher Copyright: © 2021 Elsevier Ltd

PY - 2021

Y1 - 2021

N2 - G protein–coupled receptors (GPCRs) are implicated in nearly all physiological processes in the human body and represent an important drug targeting class. The genes encoding the different GPCR (sub)types determine their specific functionality, which can be altered by natural genetic variants and isoforms. Deciphering the molecular link between sequence diversity and its functional consequences is a current challenge and critical for the comprehension of the physiological response of GPCRs. It requires a global understanding of how protein sequence translates into protein structure, how this impacts the structural motions of the protein, and, finally, how all these factors determine the receptor functionality. Here, we discuss available resources and state-of-the-art computational approaches to address this question.

AB - G protein–coupled receptors (GPCRs) are implicated in nearly all physiological processes in the human body and represent an important drug targeting class. The genes encoding the different GPCR (sub)types determine their specific functionality, which can be altered by natural genetic variants and isoforms. Deciphering the molecular link between sequence diversity and its functional consequences is a current challenge and critical for the comprehension of the physiological response of GPCRs. It requires a global understanding of how protein sequence translates into protein structure, how this impacts the structural motions of the protein, and, finally, how all these factors determine the receptor functionality. Here, we discuss available resources and state-of-the-art computational approaches to address this question.

KW - Computational biology

KW - GPCRs

KW - Receptor signaling

KW - Structural dynamics

KW - Web resources

U2 - 10.1016/j.sbi.2021.04.005

DO - 10.1016/j.sbi.2021.04.005

M3 - Review

C2 - 34052782

AN - SCOPUS:85106901736

VL - 69

SP - 150

EP - 159

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

SN - 0959-440X

ER -

ID: 273636286