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The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation. / Schaller, Sophie; Henriksen, Kim Steen; Sveigaard, Christina; Heegaard, Anne-Marie; Hélix, Nathalie; Stahlhut, Martin; Ovejero, Maria C; Johansen, Jens V; Solberg, Helene; Andersen, Thomas L; Hougaard, Dorit; Berryman, Mark; Shiødt, Christine B; Sørensen, Tobias Bjørn; Lichtenberg, Jens; Christophersen, Palle; Foged, Niels; Delaissé, Jean-Marie; Engsig, Michael T; Karsdal, Morten A.
In:
Journal of Bone and Mineral Research, Vol. 19, No. 7, 2004, p. 1144-53.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Schaller, S, Henriksen, KS, Sveigaard, C
, Heegaard, A-M, Hélix, N, Stahlhut, M, Ovejero, MC, Johansen, JV, Solberg, H, Andersen, TL, Hougaard, D, Berryman, M, Shiødt, CB, Sørensen, TB, Lichtenberg, J, Christophersen, P, Foged, N, Delaissé, J-M, Engsig, MT & Karsdal, MA 2004, '
The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation',
Journal of Bone and Mineral Research, vol. 19, no. 7, pp. 1144-53.
https://doi.org/10.1359/JBMR.040302APA
Schaller, S., Henriksen, K. S., Sveigaard, C.
, Heegaard, A-M., Hélix, N., Stahlhut, M., Ovejero, M. C., Johansen, J. V., Solberg, H., Andersen, T. L., Hougaard, D., Berryman, M., Shiødt, C. B., Sørensen, T. B., Lichtenberg, J., Christophersen, P., Foged, N., Delaissé, J-M., Engsig, M. T., & Karsdal, M. A. (2004).
The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation.
Journal of Bone and Mineral Research,
19(7), 1144-53.
https://doi.org/10.1359/JBMR.040302Vancouver
Schaller S, Henriksen KS, Sveigaard C
, Heegaard A-M, Hélix N, Stahlhut M et al.
The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation.
Journal of Bone and Mineral Research. 2004;19(7):1144-53.
https://doi.org/10.1359/JBMR.040302Author
Schaller, Sophie ; Henriksen, Kim Steen ; Sveigaard, Christina ; Heegaard, Anne-Marie ; Hélix, Nathalie ; Stahlhut, Martin ; Ovejero, Maria C ; Johansen, Jens V ; Solberg, Helene ; Andersen, Thomas L ; Hougaard, Dorit ; Berryman, Mark ; Shiødt, Christine B ; Sørensen, Tobias Bjørn ; Lichtenberg, Jens ; Christophersen, Palle ; Foged, Niels ; Delaissé, Jean-Marie ; Engsig, Michael T ; Karsdal, Morten A. / The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation. In: Journal of Bone and Mineral Research. 2004 ; Vol. 19, No. 7. pp. 1144-53.
Bibtex
@article{a17a624b93374da080288d875deabe85,
title = "The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation",
abstract = "Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption without affecting bone formation. This study indicates that chloride channel inhibitors are highly promising for treatment of osteoporosis.",
keywords = "Animals, Bone Resorption, Cells, Cultured, Chloride Channels, Coated Pits, Cell-Membrane, Female, Gene Expression Profiling, Humans, Osteoclasts, Osteogenesis, Ovariectomy, Rats, Rats, Sprague-Dawley, Tetrazoles, Tissue Distribution",
author = "Sophie Schaller and Henriksen, {Kim Steen} and Christina Sveigaard and Anne-Marie Heegaard and Nathalie H{\'e}lix and Martin Stahlhut and Ovejero, {Maria C} and Johansen, {Jens V} and Helene Solberg and Andersen, {Thomas L} and Dorit Hougaard and Mark Berryman and Shi{\o}dt, {Christine B} and S{\o}rensen, {Tobias Bj{\o}rn} and Jens Lichtenberg and Palle Christophersen and Niels Foged and Jean-Marie Delaiss{\'e} and Engsig, {Michael T} and Karsdal, {Morten A}",
year = "2004",
doi = "10.1359/JBMR.040302",
language = "English",
volume = "19",
pages = "1144--53",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "7",
}
RIS
TY - JOUR
T1 - The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation
AU - Schaller, Sophie
AU - Henriksen, Kim Steen
AU - Sveigaard, Christina
AU - Heegaard, Anne-Marie
AU - Hélix, Nathalie
AU - Stahlhut, Martin
AU - Ovejero, Maria C
AU - Johansen, Jens V
AU - Solberg, Helene
AU - Andersen, Thomas L
AU - Hougaard, Dorit
AU - Berryman, Mark
AU - Shiødt, Christine B
AU - Sørensen, Tobias Bjørn
AU - Lichtenberg, Jens
AU - Christophersen, Palle
AU - Foged, Niels
AU - Delaissé, Jean-Marie
AU - Engsig, Michael T
AU - Karsdal, Morten A
PY - 2004
Y1 - 2004
N2 - Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption without affecting bone formation. This study indicates that chloride channel inhibitors are highly promising for treatment of osteoporosis.
AB - Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption without affecting bone formation. This study indicates that chloride channel inhibitors are highly promising for treatment of osteoporosis.
KW - Animals
KW - Bone Resorption
KW - Cells, Cultured
KW - Chloride Channels
KW - Coated Pits, Cell-Membrane
KW - Female
KW - Gene Expression Profiling
KW - Humans
KW - Osteoclasts
KW - Osteogenesis
KW - Ovariectomy
KW - Rats
KW - Rats, Sprague-Dawley
KW - Tetrazoles
KW - Tissue Distribution
U2 - 10.1359/JBMR.040302
DO - 10.1359/JBMR.040302
M3 - Journal article
C2 - 15176998
VL - 19
SP - 1144
EP - 1153
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 7
ER -
