The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation
Research output: Contribution to journal › Journal article › Research › peer-review
Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption without affecting bone formation. This study indicates that chloride channel inhibitors are highly promising for treatment of osteoporosis.
| Original language | English |
|---|---|
| Journal | Journal of Bone and Mineral Research |
| Volume | 19 |
| Issue number | 7 |
| Pages (from-to) | 1144-53 |
| Number of pages | 10 |
| ISSN | 0884-0431 |
| DOIs | |
| Publication status | Published - 2004 |
| Externally published | Yes |
- Animals, Bone Resorption, Cells, Cultured, Chloride Channels, Coated Pits, Cell-Membrane, Female, Gene Expression Profiling, Humans, Osteoclasts, Osteogenesis, Ovariectomy, Rats, Rats, Sprague-Dawley, Tetrazoles, Tissue Distribution
Research areas
ID: 38426309