Relative bioavailability in man of noscapine administered in lozenges and mixture
Research output: Contribution to journal › Journal article › Research › peer-review
The bioavailability of noscapine base administered in lozenges in a dose of 100 mg to twelve healthy volunteers, in a study using an open balanced cross-over design, was compared with that of 100 mg of noscapine hydrochloride given perorally as a mixture. The bioavailability of noscapine after administration in lozenges was significantly higher than that after administration of the drug as a mixture. It is concluded that the lozenges containing noscapine base may be a valuable alternative to the conventional noscapine hydrochloride mixture.
Original language | English |
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Journal | Acta Pharmaceutica Nordica |
Volume | 4 |
Issue number | 4 |
Pages (from-to) | 309-312 |
Number of pages | 4 |
ISSN | 1100-1801 |
Publication status | Published - 1 Jan 1992 |
ID: 46100967