Osman Asghar Mirza
Associate Professor
Biopharmaceuticals
Jagtvej 162, 2100 København Ø
- 2024
- Published
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer
Pippione, A. C., Kovachka, S., Vigato, C., Bertarini, L., Mannella, I., Sainas, S., Rolando, B., Denasio, E., Piercy-Mycock, H., Romalho, L., Salladini, E., Adinolfi, S., Zonari, D., Peraldo-Neia, C., Chiorino, G., Passoni, A., Mirza, O. A., Frydenvang, K., Pors, K., Lolli, M. L. & 3 others, , 2024, In: European Journal of Medicinal Chemistry. 268, 20 p., 116193.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Functional Characterization of the Putative POT from Clostridium perfringens
Gharabli, H., Rafiq, M., Iqbal, A., Yan, R., Aduri, N. G., Sharma, N., Prabhala, B. K. & Mirza, Osman Asghar, 2023, In: Biology. 12, 5, 11 p., 651.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of key amino acid residues in AtUMAMIT29 for transport of glucosinolates
Meyer, L., Crocoll, C., Halkier, Barbara Ann, Mirza, Osman Asghar & Xu, Deyang, 2023, In: Frontiers in Plant Science. 14, 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiological response in E. coli to YdgR overexpression depends on whether the protein has an intact function
Sajid, Salvia, Salas, L. H., Rafiq, M., Lund, T., Jørgensen, M. G., Honoré, B., Christensen, L. P., Hansen, Paul Robert, Franzyk, Henrik, Mirza, Osman Asghar & Prabhala, B. K., 2023, In: Biochemical and Biophysical Research Communications. 661, p. 42-49Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate space analysis of the bacterial proton-coupled oligopeptide transporter YdgR by cheminformatics
Sajid, Salvia, Nielsen, M. M. K., Khalil, R., Hansen, Paul Robert, Franzyk, Henrik, Jørgensen, M. G., Christensen, L. P., Mirza, Osman Asghar & Prabhala, B. K., 2023, In: FEMS Microbiology Letters. 370, 9 p., fnad052.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
The Y-ome Conundrum: Insights into Uncharacterized Genes and Approaches for Functional Annotation
Sajid, Salvia, Mashkoor, M., Jørgensen, M. G., Christensen, L. P., Hansen, Paul Robert, Franzyk, Henrik, Mirza, Osman Asghar & Prabhala, B. K., 2023, (Accepted/In press) In: Molecular and Cellular Biochemistry. 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Accepted/In press
Identification of additional mechanistically important residues in the multidrug transporter styMdtM of Salmonella Typhi
Shaheen, A., Tariq, A., Ismat, F., Naveed, H., De Zorzi, R., Iqbal, M., Storici, P., Mirza, Osman Asghar, Walz, T. & Rahman, M., 2023, (Accepted/In press) In: Journal of Biomolecular Structure and Dynamics.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism
Kobberø, S. D., Gajhede, Michael, Mirza, Osman Asghar, Kløverpris, S., Kjær, T. R., Mikkelsen, J. H., Boesen, T. & Oxvig, C., 2022, In: Nature Communications. 13, 1, 16 p., 6084.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural Insights into the Substrate Transport Mechanisms in GTR Transporters through Ensemble Docking
Peña‐Varas, C., Kanstrup, Christa, Vergara‐jaque, A., González‐avendaño, M., Crocoll, C., Mirza, Osman Asghar, Dreyer, I., Nour-Eldin, Hussam Hassan & Ramírez, D., 2022, In: International Journal of Molecular Sciences. 23, 3, 20 p., 1595.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1
Rafiq, M., Ernst, H. A., Aduri, N. G., Prabhala, B. K., Tufail, S., Rahman, M., Bloch, Magnus Borup, Mirza, N., Taylor, Nicholas M I, Boesen, T., Gajhede, Michael & Mirza, Osman Asghar, 2022, In: Protein Expression and Purification. 190, 7 p., 105990.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Highly soluble and stable ‘insertion domain’ of the capsid penton base protein provides complete protection against infections caused by fowl adenoviruses
Tufail, S., Shah, M. A., Asif, T. A., Ullah, R., Shehzad, A., Ismat, F., Shah, M. S., Habib, M., Calisto, B. M., Mirza, Osman Asghar, Iqbal, M. & Rahman, M., 2022, In: Microbial Pathogenesis. 173, Part A, 6 p., 105835.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2
Krintel, C., Dorosz, J., Larsen, A. H., Thorsen, T. S., Venskutonytė, R., Mirza, Osman Asghar, Gajhede, Michael, Boesen, T. & Kastrup, Jette Sandholm Jensen, 2021, In: The FEBS Journal. 288, p. 995-1007 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sulpiride Serves, a Substrate for the Gut Microbiome
Mukhtar, I., Anwar, H., Mirza, Osman Asghar, Ali, Q., Ijaz, M. U., Hume, M., Prabhala, B. K., Iftikhar, A., Hussain, G., Sohail, M. U. & Khan, K. U. R., 2021, In: Dose-Response. 19, 1, 7 p., 1559325820987943.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PTR2/POT/NPF transporters: what makes them tick?
Prabhala, B. K., Rahman, M., Nour-Eldin, Hussam Hassan, Jørgensen, Flemming Steen & Mirza, Osman Asghar, 2021, In: Advances in Protein Chemistry and Structural Biology. 123, p. 219-240 22 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Characterization of the multidrug efflux transporter styMdtMfrom Salmonella enterica serovar Typhi
Shaheen, A., Ismat, F., Iqbal, M., Haque, A., Ul-Haq, Z., Mirza, Osman Asghar, De Zorzi, R., Walz, T. & Rahman, M., 2021, In: Proteins: Structure, Function, and Bioinformatics. 89, 9, p. 1193-1204Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars
Shaheen, A., Tariq, A., Iqbal, M., Mirza, Osman Asghar, Haque, A., Walz, T. & Rahman, M., 2021, In: Antibiotics. 10, 12, 26 p., 1455.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family
Tufail, S., Shah, M. A., Zafar, M., Asif, T. A., Shehzad, A., Shah, M. S., Habib, M., Saleemi, M. K., Muddassar, M., Mirza, Osman Asghar, Iqbal, M. & Rahman, M., 2021, In: Vaccine. 39, 27, p. 3560-3564 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Expression of ESAT-6 antigen from Mycobacterium tuberculosis in broccoli: An edible plant
Saba, K., Sameeullah, M., Asghar, A., Gottschamel, J., Latif, S., Lössl, A. G., Mirza, B., Mirza, Osman Asghar & Waheed, M. T., 2020, In: Biotechnology and Applied Biochemistry. 67, 1, p. 148-157 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional regulation of drug resistance mechanisms in Salmonella: where we stand and what we need to know
Shaheen, A., Tariq, A., Shehzad, A., Iqbal, M., Mirza, Osman Asghar, Maslov, D. A. & Rahman, M., 2020, In: World journal of microbiology & biotechnology. 36, 6, 8 p., 85.Research output: Contribution to journal › Review › Research › peer-review
- 2019
- Published
Molecular Dynamics Simulations Reveal the Proton:Peptide Coupling Mechanism in the Bacterial Proton-Coupled Oligopeptide Transporter YbgH
Aduri, N. G., Montefiori, M., Khalil, R., Gajhede, Michael, Jørgensen, Flemming Steen & Mirza, Osman Asghar, 31 Jan 2019, In: ACS Omega. 4, 1, p. 2040-2046 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In silico Epitope Prediction and Immunogenic Analysis for Penton base Epitope-focused Vaccine against Hydropericardium syndrome in chicken
Aziz, F., Tufail, S., Shah, M. A., Salahuddin Shah, M., Habib, M., Mirza, Osman Asghar, Iqbal, M. & Rahman, M., 2019, In: Virus Research. 197750.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular architecture of the Jumonji C family histone demethylase KDM5B
Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In: Scientific Reports. 9, 13 p., 4019.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol
Frydenvang, Karla Andrea, Verkade-Vreeker, M. C. A., Dohmen, F., Commandeur, J. N. M., Rafiq, M., Mirza, Osman Asghar, Jørgensen, Flemming Steen & Geerke, D. P., 2019, In: PLoS ONE. 14, 5, 15 p., e0217292.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detection of Paracetamol as substrate of the gut microbiome
Mukhtar, I., Anwar, H., Hussain, G., Rasul, A., Naqvi, S. A. R., Faisal, M. N., Mustafa, I., Malik, S., Shaukat, A., Mirza, Osman Asghar & Sohail, M. U., Mar 2019, In: Pakistan Journal of Pharmaceutical Sciences. 32, 2 (Supplementary), p. 751-757 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis methylthioalkylmalate synthase1
Petersen, A., Gram Hansen, L., Mirza, N., Crocoll, C., Mirza, Osman Asghar & Halkier, Barbara Ann, Jul 2019, In: Bioscience Reports. 39, p. 1-15 BSR20190446.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reserpine Is the New Addition into the Repertoire of AcrB Efflux Pump Inhibitors
Shaheen, A., Afridi, W. A., Mahboob, S., Sana, M., Zeeshan, N., Ismat, F., Mirza, Osman Asghar, Iqbal, M. & Rahman, M., 10 Aug 2019, In: Molecular Biology. 53, 4, p. 674-684 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Restraining the multidrug efflux transporter STY4874 of Salmonella Typhi by reserpine and plant extracts
Tariq, A., Sana, M., Shaheen, A., Ismat, F., Mahboob, S., Rauf, W., Mirza, Osman Asghar, Iqbal, M. & Rahman, M., 2019, In: Letters in Applied Microbiology. 69, 3, p. 161-167Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An Optimized Screen Reduces the Number of GA Transporters and Provides Insights Into Nitrate Transporter 1/Peptide Transporter Family Substrate Determinants
Wulff, N., Ernst, H. A., Jørgensen, M. E., Lambertz, S., Maierhofer, T., Belew, Zeinu Mussa, Crocoll, C., Motawie, Mohammed Saddik, Geiger, D., Jørgensen, Flemming Steen, Mirza, Osman Asghar & Nour-Eldin, Hussam Hassan, 3 Oct 2019, In: Frontiers in Plant Science. 10, 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An Optimized Screen Reduces the Number of GA Transporters and provides Insights into NPF Substrate Determinants
Wulff, N., Ernst, H. A., Jørgensen, M. E., Lambertz, S., Maierhofer, T., Belew, Zeinu Mussa, Crocoll, C., Motawia, M. S., Geiger, D., Jørgensen, Flemming Steen, Mirza, Osman Asghar & Nour-Eldin, Hussam Hassan, 2019, bioRxiv.Research output: Working paper › Preprint › Research
- 2018
- Published
Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state
Aduri, N. G., Ernst, H. A., Prabhala, B. K., Bhatt, S., Boesen, T., Gajhede, Michael & Mirza, Osman Asghar, 2018, In: Biochemical and Biophysical Research Communications. 495, 2, p. 1738-1743 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells
Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In: The Journal of Biological Chemistry. 293, p. 1007-1017Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Expression, purification and characterization of the human MTA2-RBBP7 complex
Brasen, C., Dorosz, J., Wiuf, A., Boesen, T., Mirza, Osman Asghar & Gajhede, Michael, 4 Feb 2017, In: Biochimica et biophysica acta. 1865, 5, p. 531-538 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterization and crystal structure of thermostable amylase from Thermotoga petrophila, reveals high thermostability and an unusual form of dimerization
Hameed, U., Price, I., Ikram-Ul-Haq, Ke, A., Wilson, D. B. & Mirza, Osman Asghar, Oct 2017, In: B B A - Proteins and Proteomics. 1865, 10, p. 1237-1245 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Origin and evolution of transporter substrate specificity within the NPF family: [with Correction]
Jørgensen, M. E., Xu, Deyang, Crocoll, C., Ernst, H. A., Ramírez, D., Motawie, Mohammed Saddik, Olsen, C. E., Mirza, Osman Asghar, Nour-Eldin, Hussam Hassan & Halkier, Barbara Ann, 2017, In: eLife. 6, 30 p., e19466.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR
Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In: Research in Microbiology. 168, 5, p. 443-449Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural Biology Meets Drug Resistance: An Overview on Multidrug Resistance Transporters
Shaheen, A., Iqbal, M., Mirza, Osman Asghar & Rahman, M., 1 Jun 2017, In: Journal of the Indian Institute of Science. 97, 2, p. 165-175 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Anandamide and 2-AG Are Endogenously Present within the Laterodorsal Tegmental Nucleus: Functional Implications for a role of eCBs in arousal
Soni, N., Prabhala, B. K., Mehta, V., Mirza, Osman Asghar & Kohlmeier, Kristi Anne, Jun 2017, In: Brain Research. 1665, p. 74-79 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Peptide Selectivity of the Proton-Coupled Oligopeptide Transporter from Neisseria meningitidis
Sharma, N., Aduri, N. G., Iqbal, A., Prabhala, B. K. & Mirza, Osman Asghar, 2016, In: Journal of Molecular Microbiology and Biotechnology. 26, 5, p. 312-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activity of the Human Rhinovirus 3C Protease Studied in Various Buffers, Additives and Detergents Solutions for Recombinant Protein Production
Ullah, R., Shah, M. A., Tufail, S., Ismat, F., Imran, M., Iqbal, M., Mirza, Osman Asghar & Rhaman, M., 2016, In: PloS one. 11, 4, 13 p., e0153436.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Salt-bridge Swapping in the EXXERFXYY Motif of Proton Coupled Oligopeptide Transporters
Aduri, N. G., Prabhala, B. K., Ernst, H. A., Jørgensen, Flemming Steen, Olsen, L. & Mirza, Osman Asghar, 2015, In: The Journal of Biological Chemistry. 290, 50, p. 29931-29940 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Monitoring mammary tumor progression and effect of tamoxifen treatment in MMTV-PymT using MRI and magnetic resonance spectroscopy with hyperpolarized [1-(13) C]pyruvate
Asghar Butt, S., Søgaard, L. V., Ardenkjaer-Larsen, J. H., Lauritzen, M. H., Engelholm, L. H., Paulson, Olaf B., Mirza, Osman Asghar, Holck, S., Magnusson, P. & Akeson, P., 16 Jan 2015, In: Magnetic Resonance in Medicine. 73, p. 51-58 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A functional EXXEK motif is essential for proton coupling and active glucosinolate transport by NPF2.11
Jørgensen, M. E., Olsen, C. E., Geiger, D., Mirza, Osman Asghar, Halkier, Barbara Ann & Nour-Eldin, Hussam Hassan, 2015, In: Plant and Cell Physiology. 56, 12, p. 2340-2350 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of synthetic peptides by mass spectrometry
Prabhala, B. K., Mirza, Osman Asghar, Højrup, P. & Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibiodies. Springer, p. 77-82Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Investigation of the substrate specificity of the proton coupled peptide transporter PepTSo from Shewanella oneidensis
Prabhala, B. K., Aduri, N. G., Hald, H. & Mirza, Osman Asghar, 2015, In: International Journal of Peptide Research and Therapeutics. 15, 21, p. 1-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of putative multidrug resistance transporters of the major facilitator-superfamily expressed in Salmonella Typhi
Shaheen, A., Ismat, F., Iqbal, M., Haque, A., De Zorzi, R., Mirza, Osman Asghar, Walz, T. & Rahman, M., 2015, In: Journal of Infection and Chemotherapy. 21, 5, p. 357–362 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL
Jensen, J. M., Aduri, N. G., Prabhala, B. K., Jahnsen, R., Franzyk, Henrik & Mirza, Osman Asghar, 24 Sep 2014, In: International Journal of Biochemistry & Cell Biology. 55, p. 311-17 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New insights into the substrate specificities of proton-coupled oligopeptide transporters from E. coli by a pH sensitive assay
Prabhala, B. K., Aduri, N. G., Jensen, J. M., Ernst, H. A., Iram, N., Rahman, M. & Mirza, Osman Asghar, 16 Jan 2014, In: FEBS Letters. 588, 4, p. 560-565Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology
Skov, L. K., Pizzut-Serin, S., Remaud-Simeon, M., Ernst, H. A., Gajhede, Michael & Mirza, Osman Asghar, Sep 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, Pt 9, p. 973-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Functional investigation of conserved membrane-embedded glutamate residues in the proton-coupled peptide transporter YjdL
Jensen, J. M., Ernst, H. A., Wang, X., Hald, H., Ditta, A. C., Ismat, F., Rahman, M. & Mirza, Osman Asghar, Mar 2012, In: Protein and Peptide Letters. 19, 3, p. 282-287Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the proton-coupled oligopeptide transporter YjdL
Jensen, J. M., Simonsen, F. C., Mastali, A., Hald, H., Lillebro, I., Diness, Frederik, Olsen, L. & Mirza, Osman Asghar, Nov 2012, In: Peptides. 38, 1, p. 89-93 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302772
Most downloads
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289
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Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
275
downloads
Origin and evolution of transporter substrate specificity within the NPF family: [with Correction]
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
243
downloads
Activity of the Human Rhinovirus 3C Protease Studied in Various Buffers, Additives and Detergents Solutions for Recombinant Protein Production
Research output: Contribution to journal › Journal article › Research › peer-review
Published