Petrine Wellendorph
Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
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α4βδ GABA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)
Absalom, N., Karim, N., Eghorn, L. F., Villumsen, I. S., Bay, T., Bräuner, Hans, Frølund, Bente, Clausen, Rasmus Prætorius, Olsen, Jesper Velgaard, Knudsen, Gitte Moos, Chebib, M. & Wellendorph, Petrine, 14 Aug 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 33, p. 13404-13409 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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gamma-Aminobutyric Acid and Glycine Neurotransmitter Transporters
Wellendorph, Petrine, Jacobsen, Julie, Skovgaard-Petersen, J., Jurik, A., Vogensen, S. B., Ecker, G., Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2017, Transporters As Drug Targets.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Unraveling the Molecular Determinants for GABA Transporter Subtype Selectivity
Kickinger, S., Al-Khawaja, A., Haugaard, A. S., Lie, M. E. K., Bavo, Francesco, Loffler, R., Damgaard, M., Frølund, Bente, Ecker, G. F. & Wellendorph, Petrine, 2020, p. 130A-130A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers
Olsen, Christian Adam, Mellor, I. R., Wellendorph, Petrine, Usherwood, P. N. R., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2006, In: ChemMedChem. 1, 3, p. 303-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transmembrane transporter proteins: Capturing transport in motion
Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
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The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4
Thiesen, L., Belew, Zeinu Mussa, Griem-Krey, Nane, Pedersen, Stine Helene Falsig, Crocoll, C., Nour-Eldin, Hussam Hassan & Wellendorph, Petrine, 15 Feb 2020, In: European Journal of Pharmaceutical Sciences. 143, p. 1-9 105203.Research output: Contribution to journal › Journal article › Research › peer-review
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The rat GPRC6A: cloning and characterization
Wellendorph, Petrine, Burhenne, N., Christiansen, B., Walter, B., Schmale, H. & Bräuner, Hans, 15 Jul 2007, In: Gene. 396, 2, p. 257-267 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The emerging role of promiscuous 7TM receptors as chemosensors for food intake
Wellendorph, Petrine, Johansen, L. D. & Bräuner, Hans, 1 Jan 2010, Incretins and insulin secretion. Litwack, G. (ed.). Amsterdam: Elsevier Editora, Vol. 84. p. 151-184 (Vitamins & hormones, Vol. 84).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release
Smajilovic, S., Clemmensen, Christoffer, Johansen, L. D., Wellendorph, Petrine, Holst, Jens Juul, Thams, P. G., Ogo, E. & Bräuner, Hans, 2013, In: Amino Acids. 44, 2, p. 383-390 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα
Griem-Krey, Nane, Klein, A. B., Clausen, B. H., Namini, M. R. J., Nielsen, P. V., Bhuiyan, M., Nagaraja, R. Y., De Silva, T. M., Sobey, C. G., Cheng, H. C., Orset, C., Vivien, D., Lambertsen, K. L., Clarkson, A. N. & Wellendorph, Petrine, 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 8, p. 1419-1434Research output: Contribution to journal › Journal article › Research › peer-review
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The G protein-coupled receptor, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function
Clemmensen, Christoffer, Smajilovic, S., Wellendorph, Petrine & Bräuner, Hans, 2014, In: British Journal of Pharmacology. 171, 5, p. 1129-1141Research output: Contribution to journal › Journal article › Research › peer-review
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The CaMKIIα hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction
Griem-Krey, Nane, Gauger, Stine Juul, Gowing, E. K., Thiesen, L., Frølund, Bente, Clarkson, A. N. & Wellendorph, Petrine, 2022, In: Biomedicine and Pharmacotherapy. 156, 10 p., 113895.Research output: Contribution to journal › Journal article › Research › peer-review
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The Binding of Alpinia galanga Oil and Its Nanoemulsion to Mammal GABA(A) Receptors Using Rat Cortical Membranes and an In Silico Modeling Platform
Khumpirapang, N., Suknuntha, K., Wongrattanakamon, P., Jiranusornkul, S., Anuchapreeda, S., Wellendorph, Petrine, Mullertz, Anette , Rades, Thomas & Okonogi, S., 2022, In: Pharmaceutics. 14, 3, 15 p., 650.Research output: Contribution to journal › Journal article › Research › peer-review
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TREATMENT OF CNS DISORDERS WITH SLEEP DISTURBANCES
Wellendorph, Petrine, Kornum, Birgitte Rahbek & Frølund, Bente, 2020, Patent No. WO2020259787 , 30 Dec 2020, Priority date 28 Jun 2019, Priority No. DK2019PA70415 20190628Research output: Patent
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Synthesis, pharmacological activity and molecular modeling studies of a series of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogues as betaine/GABA transporter 1 (BGT1) substrate-inhibitors
Kickinger, S., Al-Khawaja, A., Haugaard, A. S., Loeffler, R., Damgaard, M., Eckert, G., Frølund, Bente & Wellendorph, Petrine, 19 Aug 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Synthesis of gamma-Aminobutyric Acid (GABA) Analogues Conformationally Restricted by Bicyclo[3.1.0]hexane/hexene or [4.1.0]Heptane/heptene Backbones as Potent Betaine/GABA Transporter Inhibitors
Mitsui, K., Lie, M. E. K., Saito, N., Fujiwara, K., Watanabe, M., Wellendorph, Petrine & Shuto, S., 2022, In: Organic Letters. 24, 23, p. 4151-4154Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and Pharmacological Evaluation of [C-11]4-Methoxy-N-[2-(thiophen-2-yl) imidazo[1,2-a] pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the delta-Subunit-Containing gamma-Aminobutyric Acid Type A Receptors
L'Estrade, E. T., Hansen, H. D., Falk-Petersen, C., Haugaard, A., Griem-Krey, Nane, Jung, S., Lueddens, H., Schirmeister, T., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, May 2019, In: ACS Omega. 4, 5, p. 8846-8851Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based ?-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect
Bavo, Francesco, De-Jong, H., Petersen, Jonas Odgaard, Falk-Petersen, C. B., Löffler, R., Sparrow, E., Rostrup, F., Eliasen, Jannik Nicklas, Wilhelmsen, K. S., Barslund, K., Bundgaard, C., Nielsen, Birgitte, Kristiansen, Uffe, Wellendorph, Petrine, Bogdanov, Y. & Frølund, Bente, 2021, In: Journal of Medicinal Chemistry. 64, 24, p. 17795-17812Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1)
Jørgensen, L., Al-Khawaja, A., Kickinger, S., Vogensen, S. B., Skovgaard-Petersen, J., Rosenthal, E., Borkar, N., Löffler, R., Madsen, K. K., Bräuner, Hans, Schousboe, Arne, Ecker, G. F., Wellendorph, Petrine & Clausen, Rasmus Prætorius, 9 Oct 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 8834-8846Research output: Contribution to journal › Journal article › Research › peer-review
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Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors
Bräuner, Hans, Wellendorph, Petrine & Jensen, Anders A., 2007, In: Current Drug Targets. 8, 1, p. 169-184Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserine
Bavo, Francesco, Kickinger, Stefanie, Lie, M. E. K., Avgerinos, Christos, Wilhelmsen, Kristine Sloth, Wellendorph, Petrine & Frølund, Bente, 2023, In: Medicinal Chemistry Research. 32, p. 2299–2324Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function
Kickinger, S., Hellsberg, E., Frølund, Bente, Schousboe, Arne, Ecker, G. F. & Wellendorph, Petrine, 2019, In: Neuropharmacology. 161, 14 p., 107644.Research output: Contribution to journal › Review › Research › peer-review
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Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors
Rostrup, F., Falk-petersen, C. B., Harpsøe, Kasper, Buchleithner, S., Conforti, I., Jung, S., Gloriam, David E., Schirmeister, T., Wellendorph, Petrine & Frølund, Bente, 22 Apr 2021, In: Journal of Medicinal Chemistry. 64, 8, p. 4730-4743 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA-B1-deficient mice
Kaupmann, K., Cryan, J. F., Wellendorph, Petrine, Mombereau, C., Sansig, G., Klebs, K., Schmutz, M., Froestl, W., van der Putten, H., Mosbacher, J., Bräuner, Hans, Waldmeier, P. & Bettler, B., Nov 2003, In: European Journal of Neuroscience. 18, 10, p. 2722-30Research output: Contribution to journal › Journal article › Research › peer-review
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Silencing of spontaneous activity at α4β1/3δ GABAA receptors in hippocampal granule cells reveals different ligand pharmacology
Dalby, N. O., Falk-Petersen, C. B., Leurs, U., Scholze, P., Krall, J., Frølund, Bente & Wellendorph, Petrine, 2020, In: British Journal of Pharmacology. 177, 17, p. 3975-3990Research output: Contribution to journal › Journal article › Research › peer-review
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Selective mGAT2 (BGT-1) GABA Uptake Inhibitor: Design, synthesis and pharmacological characterization
Vogensen, S. B., Jørgensen, L., Madsen, K. K., Borkar, N. N., Wellendorph, Petrine, Skovgaard-Petersen, J., Schousboe, Arne, White, H. S., Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 11 Feb 2013, In: Journal of Medicinal Chemistry. 56, 5, p. 2160-2164 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand
Kuhne, S., Nøhr, A. C., Marek, A., Elbert, T., Klein, A. B., Bräuner, Hans, Wellendorph, Petrine & Pedersen, D. S., 2016, In: RSC Advances. 6, 2, p. 947-952 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites
Jensen, C. H., Hansen, H. D., Bay, T., Vogensen, S. B., Lehel, S., Thiesen, L., Bundgaard, C., Clausen, Rasmus Prætorius, Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, 18 Jan 2017, In: A C S Chemical Neuroscience. 8, 1, p. 22-27 6 p.Research output: Contribution to journal › Letter › Research › peer-review
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Radiolabeled HOCPCA as a highly useful tool in drug discovery and pharmacology
Griem-Krey, Nane, Frølund, Bente, Marek, A. & Wellendorph, Petrine, 2021, In: Journal of Labelled Compounds and Radiopharmaceuticals. 64, 2, 77 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Radioiododestannyllation of novel GHB neuroreceptor ligands
Pedersen, M. H. F., Høg, S., Wellendorph, Petrine & Martiny, L., 2010, In: Journal of Labelled Compounds and Radiopharmaceuticals. 5-6, p. 318-320Research output: Contribution to journal › Conference article › Research › peer-review
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Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids
Smajilovic, S., Wellendorph, Petrine & Bräuner, Hans, 2014, In: Current Pharmaceutical Design. 20, p. 2693-702 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin
Eghorn, L. F., Høstgaard-Jensen, K., Kongstad, Kenneth Thermann, Bay, T., Higgins, D., Frølund, Bente & Wellendorph, Petrine, 5 Oct 2014, In: European Journal of Pharmacology. 740, p. 570-577 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain
Wellendorph, Petrine, Høg, S., Skonberg, C. & Bräuner, Hans, 2009, In: Fundamental and Clinical Pharmacology. 23, 2, p. 207-213 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations
Christiansen, B., Hansen, K. B., Wellendorph, Petrine & Bräuner, Hans, 2007, In: British Journal of Pharmacology. 150, 6, p. 798-807Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes
Villumsen, I. S., Wellendorph, Petrine & Smart, T. G., 2015, In: BMC Neuroscience. 16, 8, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological Identification of a Guanidine-Containing β-Alanine Analogue with Low Micromolar Potency and Selectivity for the Betaine/GABA Transporter 1 (BGT1)
Al-Khawaja, A. M. A., Petersen, J. G., Damgaard, M., Jensen, M. H., Vogensen, S. B., Lie, M. E. K., Kragholm, B., Bräuner, Hans, Clausen, Rasmus Prætorius, Frølund, Bente & Wellendorph, Petrine, 23 May 2014, In: Neurochemical Research. 39, 10, p. 1988-1996 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects
Lie, M. E. K., Kickinger, S., Skovgaard-Petersen, J., Ecker, G. F., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Wellendorph, Petrine, 2020, In: Neurochemical Research. 45, p. 1551–1565Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological Characterization of [3H]ATPCA as a Substrate for Studying the Functional Role of the Betaine/GABA Transporter 1 and the Creatine Transporter
Al-Khawaja, A., Haugaard, A. S., Marek, A., Löffler, R., Thiesen, L., Santiveri, M., Damgaard, M., Bundgaard, C., Frølund, Bente & Wellendorph, Petrine, 21 Mar 2018, In: A C S Chemical Neuroscience. 9, 3, p. 545–554Research output: Contribution to journal › Journal article › Research › peer-review
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Novel radioiodinated γ-hydroxybutyric acid analogues for radiolabeling and photolinking of high-affinity γ-hydroxybutyric acid binding sites
Wellendorph, Petrine, Høg, S., Sabbatini, P., Pedersen, M. H. F., Martiny, L., Knudsen, Gitte Moos, Frølund, Bente, Clausen, Rasmus Prætorius & Bräuner, Hans, 2010, In: Journal of Pharmacology and Experimental Therapeutics. 335, 2, p. 458-464Research output: Contribution to journal › Journal article › Research › peer-review
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Novel high-affinity and selective biaromatic 4-substituted ¿-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies
Høg, S., Wellendorph, Petrine, Nielsen, Birgitte, Frydenvang, Karla Andrea, Dahl, I. F., Bräuner, Hans, Brehm, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2008, In: Journal of Medicinal Chemistry. 51, 24, p. 8088-8095Research output: Contribution to journal › Journal article › Research › peer-review
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Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain
Wellendorph, Petrine, Høg, S., Greenwood, J. R., de Lichtenberg, A., Nielsen, Birgitte, Frølund, Bente, Brehm, L., Clausen, Rasmus Prætorius & Bräuner, Hans, Oct 2005, In: Journal of Pharmacology and Experimental Therapeutics. 315, 1, p. 346-51Research output: Contribution to journal › Journal article › Research › peer-review
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Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model
Petersen, Louise Piilgaard, Rose, Laura, Justinussen, Jessica, Hviid, C. G., Lemcke, René, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2023, In: Sleep. 46, 9, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions
Wellendorph, Petrine, Johansen, L. D., Jensen, Anders A., Casanova, E., Gassmann, M., Deprez, P., Clément-Lacroix, P., Bettler, B. & Bräuner, Hans, 2009, In: Journal of Molecular Endocrinology. 42, 3, p. 215-223Research output: Contribution to journal › Journal article › Research › peer-review
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New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites
Vogensen, S. B., Marek, A., Bay, T., Wellendorph, Petrine, Kehler, J., Bundgaard, C., Frølund, Bente, Pedersen, M. H. F. & Clausen, Rasmus Prætorius, 2013, In: Journal of Medicinal Chemistry. 56, 20, p. 8201–8205Research output: Contribution to journal › Journal article › Research › peer-review
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N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection
Ameen, S. S., Griem-Krey, N., Dufour, A., Hossain, M. I., Hoque, A., Sturgeon, S., Nandurkar, H., Draxler, D. F., Medcalf, R. L., Kamaruddin, M. A., Lucet, I. S., Leeming, M. G., Liu, D., Dhillon, A., Lim, J. P., Basheer, F., Zhu, H. J., Bokhari, L., Roulston, C. L., Paradkar, P. N. & 7 others, , 2023, In: Molecular & cellular proteomics : MCP. 22, 5, 100543.Research output: Contribution to journal › Journal article › Research › peer-review
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Målrettet fisketur i hjernen giver ny viden om Fantasy’s virkningssted
Villumsen, I. S., Vogensen, S. B., Frølund, Bente, Clausen, Rasmus Prætorius & Wellendorph, Petrine, 2011, In: Lægemiddelforskning. 2011, p. 26-28Research output: Contribution to journal › Journal article › Communication
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Målrettet fisketur i hjernen giver ny viden om Fantasys virkningssted
Villumsen, I. S., Vogensen, S. B., Frølund, Bente, Clausen, Rasmus Prætorius & Wellendorph, Petrine, Dec 2011, In: Lægemiddelforskning. 2011, p. 26-28Research output: Contribution to journal › Journal article › Communication
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Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α1β2δ GABAA receptors
Damgaard, M., Al-Khawaja, A., Nittegaard-Nielsen, M., Petersen, R. F., Wellendorph, Petrine & Frølund, Bente, 15 Jun 2017, In: European Journal of Medicinal Chemistry. 138, p. 300-312 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients
Wellendorph, Petrine, Johansen, L. D. & Bräuner, Hans, 2009, In: Molecular Pharmacology. 76, 3, p. 453-465Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor
Wellendorph, Petrine & Bräuner, Hans, 23 Jun 2004, In: Gene. 335, p. 37-46Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1301791
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Kemogenomik: Receptoren set fra lægemiddelstoffets synspunkt
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Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor
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Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method
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