Søren Brøgger Christensen

Søren Brøgger Christensen

Professor emeritus, Professor, emeritus

Member of:

    ORCID: 0000-0002-5773-6874

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    1. Published

      Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection

      Chen, M., Theander, Thor Grundtvig, Christensen, Søren Brøgger, Hviid, Lars, Zhai, L. & Kharazmi, A., 1994, In: Antimicrobial Agents and Chemotherapy. 38, 7, p. 1470-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania

      Chen, M., Christensen, Søren Brøgger, Blom, J., Lemmich, E., Nadelmann, L., Fich, K., Theander, Thor Grundtvig & Kharazmi, A., 1993, In: Antimicrobial Agents and Chemotherapy. 37, 12, p. 2550-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Limonoids from Khaya senegalensis

      Khalid, S., Friedrichsen, G., Kharazmi, A., Theander, Thor Grundtvig, Olsen, C. & Christensen, Søren Brøgger, 1998, In: Phytochemistry. 49, 6, p. 1769-1772 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Localization and in-vivo characterization of Thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

      Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, Kirsten, Andersen-Ranberg, Johan, Nyberg, N., Christensen, Søren Brøgger & Simonsen, H. T., 2017, In: Plant Physiology. 174, 1, p. 56-72 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Localization of the acyl groups in proazulene guaianolides from Thapsia transtagana and Thapsia garganica

      Avato, P., Cornett, Claus, Andersen, A., Smitt, U. W. & Christensen, Søren Brøgger, 1993, In: Journal of Natural Products. 56, 3, p. 411-415 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Lægemidler fra naturstoffer: fortid eller fremtid?

      Jaroszewski, J. W., Christensen, Søren Brøgger, Franzyk, Henrik, Stærk, Dan & Ziegler, H., 2008, In: Lægemiddelforskning. p. 4-6

      Research output: Contribution to journal › Journal article › Communication

    7. Published

      Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

      Hassan, A. R., El-Kousy, S. M., El-Toumy, S. A., Frydenvang, Karla Andrea, Tung, T. T., Olsen, J., Nielsen, J. & Christensen, Søren Brøgger, 27 Oct 2017, In: Journal of Natural Products. 80, p. 2830-2834 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Mild psychoactive constituents of Mentha aquatica L.

      Stafford, G. I., Almqvist, J. P., Vangsøe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A., Jäger, A. K. & van Staden, J., 2008, In: South African Journal of Botany. 2, p. 389

      Research output: Contribution to journal › Conference abstract in journal › Research

    9. Published

      Mipsagargin: The Beginning—Not the End—of Thapsigargin Prodrug-Based Cancer Therapeutics

      Isaacs, J. T., Brennen, W. N., Christensen, Søren Brøgger & Denmeade, S. R., 2021, In: Molecules. 26, 24, 7469.

      Research output: Contribution to journal › Review › Research › peer-review

    10. Published

      Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

      Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M. H., Yli-Kauhaluoma, J., Talman, V., Franzyk, Henrik, Tuominen, R. K. & Christensen, Søren Brøgger, 2020, In: A C S Medicinal Chemistry Letters. 11, 5, p. 671-677 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities

      Nielsen, S. F., Kharazmi, A. & Christensen, Søren Brøgger, 1998, In: Bioorganic & Medicinal Chemistry. 6, 7, p. 937-45 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Molluscicidal saponins from Phytolacca dodecandra

      Thiilborg, S. T., Christensen, Søren Brøgger, Cornett, Claus, Olsen, C. E. & Lemmich, E., 1993, In: Phytochemistry. 32, 5, p. 1167-1171 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Molluscicidal saponins from a Zimbabwean strain of Phytolacca dodecandra

      Thiilborg, S. T., Christensen, Søren Brøgger, Cornett, Claus, Olsen, C. E. & Lemmich, E., 1994, In: Phytochemistry. 36, 3, p. 753-759 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Muscimol analogues. I. Syntheses of 4- and 8-aminocycloheptenol[1,2 d]isoxazol-3-ols and 4-(3-aminopropyl)-5-methyl-3-isoxazolol

      Krogsgaard-Larsen, Povl, Natova, L. & Christensen, Søren Brøgger, 1 Jan 1977, In: ACTA CHEM. SCAND.. B31, 7, p. 577-583 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      NEW PROAZULENE GUAIANOLIDES FROM THAPSIA-VILLOSA

      Smitt, U. W., Cornett, Claus, Andersen, A., Christensen, Søren Brøgger & Avato, P., 1990, In: Journal of Natural Products. 53, 6, p. 1479-1484 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Natural Products that Changed Society

      Christensen, Søren Brøgger, 2021, In: Biomedicines. 9, 5, 31 p., 472.

      Research output: Contribution to journal › Review › Research › peer-review

    17. Published

      Neglected diseases

      Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 347-368 22 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    18. Published

      Neglected diseases

      Christensen, Søren Brøgger, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 341-358

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

    19. Published

      Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death

      Szalai, P., Parys, J. B., Bultynckb, G., Christensen, Søren Brøgger, Nissen, P., Møller, J. V. & Engedal, N., Dec 2018, In: Cell Calcium. 76, p. 48-61 14 p., https://doi.org/10.1016/j.ceca.2018.09.005.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Nortrilobolide, a new potent guaianolide secretagogue from Thapsia garganica

      Smitt, U. W. & Christensen, Søren Brøgger, 25 Apr 1991, In: Planta Medica. 57, 2, p. 196-197 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Noter til bioorganisk kemi M23-1

      Franzyk, Henrik, Christensen, Søren Brøgger & Jaroszewski, J. W., 2007, København: Københavns Universitet, Det Farmaceutiske Fakultet, Institut for Medicinalkemi.

      Research output: Book/Report › Compendium/lecture notes › Education

    22. Published

      Novel Guaiane Esters from Thapsia villosa

      Lemmich, E., Smitt, U. W., Kastrup, Jette Sandholm Jensen & Christensen, Søren Brøgger, 1991, In: Phytochemistry. 30, p. 2987-2990 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Novel inhibitory activity of the Staphylococcus aureus NorA efflux pump by a kaempferol rhamnoside isolated from Persea lingue Nees

      Holler, J. G., Christensen, Søren Brøgger, Slotved, H., Rasmussen, H. B., Guzman, A., Olsen, C. E., Petersen, B. & Mølgaard, Per, 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1138 - 1144 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Novel thapsigargin analogues and methods of preparing them

      Doan, T. Q. N., Christensen, Søren Brøgger & Crestey, F. L. J., 30 Dec 2015, Patent No. WO2015197860 A2, Priority date 27 Jun 2014, Priority No. DK20140070395 20140627

      Research output: Patent

    25. Published

      Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E2P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump

      Mahmmoud, Y. A. & Christensen, Søren Brøgger, Oct 2011, In: BBA General Subjects. 1808, 10, p. 2413-2420

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Organic hydroxylamine derivatives. VII. Isoxazolin 5 ones. An investigation of a reaction sequence previously stated to give 3 hydroxyisoxazoles

      Krogsgaard-Larsen, Povl, Christensen, Søren Brøgger & Hjeds, H., 1 Jan 1973, In: Acta Chemica Scandinavica. 27, 8, p. 2802-2812 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Organic hydroxylamine derivatives. VIII. Structural analogues of GABA of the isoxazole enol betaine type. Synthesis of 5,6,7,8 tetrahydro 4H isoxazolo[3,4 d]azepin 3 ol zwitterion and some derivatives

      Krogsgaard-Larsen, Povl, Hjeds, H. & Christensen, Søren Brøgger, 1 Jan 1973, In: Acta Chemica Scandinavica. 27, 9, p. 3251-3258 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Perturbing dissimilar biomolecular targets from natural product scaffolds and focused chemical decoration.

      Nielsen, J., Tung, T. T., Tim, H. J., Trong Tuan, D., Anja T., F., Michael, G. & Christensen, Søren Brøgger, 2 Apr 2017. 1 p.

      Research output: Contribution to conference › Poster › Research › peer-review

    29. Published

      Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug

      Janssen, S., Rosen, D. M., Ricklis, R. M., Dionne, C. A., Lilja, H., Christensen, Søren Brøgger, Isaacs, J. T. & Denmeade, S. R., 1 Mar 2006, In: Prostate. 66, 4, p. 358-368 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Phorbol Rearrangements

      Zimmermann, T., Franzyk, Henrik & Christensen, Søren Brøgger, 28 Sep 2018, In: Journal of Natural Products. 81, 9, p. 2134-2137 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Phytochemical and pharmacological investigations of the genus Thapsia (Apiaceae)

      Rasmussen, U., Christensen, Søren Brøgger & Sandberg, F., 1 Jan 1978, In: PLANTA MED.. 33, 3, p. 301-302 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Phytochemistry of the genus Thapsia

      Rasmussen, U., Christensen, Søren Brøgger & Sandberg, F., 1 Jan 1981, In: Planta Medica. 43, 4, p. 336-341 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Planternes slægtskab som skattekort til nye lægemidler

      Rønsted, Nina, Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H. & Jäger, A. K., Dec 2010, In: Lægemiddelforskning. 2010, p. 19-21

      Research output: Contribution to journal › Journal article › Communication

    34. Published

      Prenylated acetophenones from Melicope obscura and Melicope obtusifolia ssp. obtusifolia var. arborea and their distribution in Rutaceae

      Adsersen, A., Smitt, U. W., Simonsen, H. T., Christensen, Søren Brøgger & Jaroszewski, J. W., 2007, In: Biochemical Systematics and Ecology. 35, 7, p. 447-453

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

      Zimmermann, T., Christensen, Søren Brøgger & Franzyk, Henrik, 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Preparations of deuterium labelled guvacine and isoguvacine

      Christensen, Søren Brøgger & Krogsgaard-Larsen, Povl, 1 Jan 1980, In: Journal of Labelled Compounds and Radiopharmaceuticals. 17, 2, p. 191-202 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Proacaciberin, A cyanogenic glycoside from Acacia sieberiana var. Woodii

      Nartey, F., Brimer, L. & Christensen, Søren Brøgger, 1981, In: Phytochemistry. 20, 6, p. 1311-1314 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer

      Denmeade, S. R., Jakobsen, C. M., Janssen, S., Khan, S. R., Garrett, E. S., Lilja, H., Christensen, Søren Brøgger & Isaacs, J. T., 2 Jul 2003, In: National Cancer Institute. Journal (Online). 95, 13, p. 990-1000 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Psychotropic constituents of Mentha aquatica L.

      Van Staden, J., Stafford, G. ,. I., Almqvist, J. P., Vangsoe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A. & Jäger, A., Aug 2007, In: Planta Medica. 73, 9, p. 928-929

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Psychotropic constituents of Mentha aquatica L.

      van Staden, J., Stafford, G. I., Almqvist, J. P., Vangsøe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A. & Jäger, A. K., 2007.

      Research output: Contribution to conference › Poster › Research

    41. Published

      S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis

      Sheykhzade, Majid, Smajilovic, S., Issa, A., Haunsø, Stig, Christensen, Søren Brøgger & Tfelt-Hansen, J., 28 Sep 2008, In: European Journal of Pharmacology. 593, 1-3, p. 79-86

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN

      Andersen, A., Cornett, Claus, Lauridsen, A., Olsen, C. E. & Christensen, Søren Brøgger, 1994, In: Acta Chemica Scandinavica. Supplementum. 48, 4, p. 340-346 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer

      Janssen, S., Jakobsen, C. M., Rosen, D. M., Ricklis, R. M., Reineke, U., Christensen, Søren Brøgger, Lilja, H. & Denmeade, S. R., 1 Nov 2004, In: Molecular Cancer Therapeutics. 3, 11, p. 1439-1450 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)

      Stafford, G. I., Birer, C., Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H., Jäger, A. & Rønsted, Nina, Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

      Rubal, J. J., Guerra, F. M., Moreno-Dorado, F. J., Jorge, Z. D., Massanet, G. M., Søhoel, H., Smitt, U. W., Frydenvang, Karla Andrea, Christensen, Søren Brøgger, Nielsen, C. & Eriksson, M., 2006, In: Journal of Natural Products. 69, 11, p. 1566-71 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Sesquiterpenoids from Thapsia species and medicinal chemistry of the thapsigargins.

      Christensen, Søren Brøgger, Andersen, A. & Smitt, U. W., 1997, In: Fortschritte der Chemie organischer Naturstoffe. Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles. 71, p. 129-167 39 p.

      Research output: Contribution to journal › Review › Research › peer-review

    47. Published

      Stimulation of arachidonic acid metabolism in rat peritoneal macrophages by thapsigargin, a non-(12-O-tetradecanoylphorbol-13-acetate) (TPA)-type tumor promoter

      Ohuchi, K., Sugawara, T., Watanabe, M., Hirasawa, N., Tsurufuji, S., Fujiki, H., Sugimura, T. & Christensen, Søren Brøgger, 1 Jun 1987, In: Journal of Cancer Research and Clinical Oncology. 113, 4, p. 319-324 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Structural elucidation and partial synthesis of 3-hydroxyheterodendrin, a cyanogenic glucoside from Acacia sieberiana var. woodii

      Brimer, L., Christensen, Søren Brøgger, Jaroszewski, J. W. & Nartey, F., 1981, In: Phytochemistry. 20, 9, p. 2221-2223 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Structure and biological activity of sesquiterpene lactones from Thapsia species and of analogue derivatives

      Rasmussen, U., Christensen, Søren Brøgger & Patkar, S. A., 1 Jan 1982, In: Planta Medica. 45, 3, p. P23

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Structure of histamine releasing guaianolides from Thapsia species

      Christensen, Søren Brøgger, Norup, E., Rasmussen, U. & Øgaard Madsen, J., 1984, In: Phytochemistry. 23, 8, p. 1659-1663 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

      Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Structure-activity relationships of analogues of thapsigargin modified at O-11 and O-12

      Nielsen, S. F., Thastrup, Ole, Pedersen, R., Olsen, C. E. & Christensen, Søren Brøgger, 1995, In: Journal of Medicinal Chemistry. 38, 2, p. 272-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Structure-activity relationships of thapsigargin

      Nielsen, S. F., Andersen, A., Olsen, C. E., Treimann, M., Thastrup, Ole & Christensen, Søren Brøgger, 1 Dec 1993, In: Planta Medica. 59, 7 SUPPL., p. A678-A679

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida

      Sittie, A. A., Lemmich, E., Olsen, C. E., Hviid, Lars, Kharazmi, A., Nkrumah, F. K. & Christensen, Søren Brøgger, 1999, In: Planta Medica. 65, 3, p. 259-61 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+-Transport ATPase (SPCA1a)

      Jialin, C., de Raeymaecker, J., Hovgaard, J. B., Smaardijk, S., Vandecaetsbeek, I., Wuytack, F., Møller, J. V., Eggermont, J., de Meyer, M., Christensen, Søren Brøgger & Vangheluwe, P., 2017, In: Journal of Biological Chemistry. 292, 17, p. 6938-6951 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Synergistic stimulation of histamine release from rat peritoneal mast cells by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters

      Ohuchi, K., Hirasawa, N., Takahashi, C., Watanabe, M., Tsurufuji, S., Fujiki, H., Suganuma, M., Hakii, H., Sugimura, T. & Christensen, Søren Brøgger, 16 Jun 1986, In: BBA - Molecular Cell Research. 887, 1, p. 94-99 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Syntheses of 11-hydroxylated guaianolides

      Lauridsen, A., Cornett, Claus, Vulpius, T., Moldt, P. & Christensen, Søren Brøgger, 1996, In: Acta Chemica Scandinavica. Supplementum. 50, 2, p. 150-157 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Synthesis of antiparasitic licorice chalcones

      Nielsen, S. F., Chen, M., Theander, Thor Grundtvig, Kharazmi, A. & Christensen, Søren Brøgger, 1995, In: Bioorganic & Medicinal Chemistry Letters. 5, p. 449-452 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Synthesis of the thapsigargins

      Ley, S. V., Antonello, A., Balskus, E. P., Booth, D. T., Christensen, Søren Brøgger, Cleator, E., Gold, H., Högenauer, K., Hünger, U., Myers, R. M., Oliver, S. F., Simic, O., Smith, M. D., Søhoel, H. & Woolford, A. J. A., 17 Aug 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 33, p. 12073-12078 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Synthesis, isolation and identification of glucuronides and mercapturic acids of a novel antiparasitic agent, licochalcone A

      Nadelmann, L., Tjornelund, J., Hansen, S. H., Cornett, Claus, Sidelmann, U. G., Braumann, U., Christensen, E. & Christensen, Søren Brøgger, 1997, In: Xenobiotica. 27, 7, p. 667-680 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Targeting Toxins toward Tumors

      Franzyk, Henrik & Christensen, Søren Brøgger, 2021, In: Molecules. 26, 5, 23 p., 1292.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Targeting thapsigargin towards tumors

      Christensen, Søren Brøgger, Doan, T. Q. N., Paulsen, E. S., Sehgal, P., Møller, J. V., Nissen, P., Denmeade, S. R., Isaacs, J. T. & Dionne, C. A., 2015, In: Steroids. 97, p. 2-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Thapsigargin: a novel molecular probe for studying intracellular calcium release and storage

      Thastrup, Ole, Dawson, A. P., Scharff, O., Foder, B., Cullen, P. J., Drøbak, B. K., Bjerrum, P. J., Christensen, Søren Brøgger & Hanley, M. R., 1994, In: Agents and Actions. 43, 3-4, p. 187-93 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Thapsigargin affinity purification of intracellular P2A-type Ca2+ ATPases

      Vandecaetsbeek, I., Christensen, Søren Brøgger, Liu, Huizhen, van Veldhoven, P. P., Waelkens, E., Eggermont, J., Raeymaekers, L., Møller, J. V., Nissen, P., Wuytack, F. & Vangheluwe, P., 1 May 2011, In: BBA General Subjects. 1813, 5, p. 1118-1127

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Published

      Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis

      Hakii, H., Fujiki, H., Suganuma, M., Nakayasu, M., Tahira, T., Sugimura, T., Scheuer, P. J. & Christensen, Søren Brøgger, 1 Jun 1986, In: Journal of Cancer Research and Clinical Oncology. 111, 3, p. 177-181 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Published

      Thapsigargin, constitution of a sesquiterpene lactone histamine liberator from thapsia garganica

      Christensen, Søren Brøgger, Rasmussen, U. & Christophersen, C., 1980, In: Tetrahedron Letters. 21, 39, p. 3829-3830 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development.

      Doan, T. Q. N. & Christensen, Søren Brøgger, Oct 2015, In: Current Pharmaceutical Design. 21, 38, p. 5505-5517 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    68. Published

      Thapsigargin-induced increase in cytoplasmic Ca2+concentration and aldosterone production in rat adrenal glomerulosa cells: Interaction with potassium and angiotensin-II

      Hajnóczky, G., Várnai, P., Holló, Z., Christensen, Søren Brøgger, Balla, T., Enyedi, P. & Spät, A., 1 May 1991, In: Endocrinology. 128, 5, p. 2639-2644 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L

      Rasmussen, U., Christensen, Søren Brøgger & Sandberg, F., 1 Jan 1978, In: Acta Pharmaceutica Suecica. 15, 2, p. 133-140 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response

      Ali, H., Christensen, Søren Brøgger, Foreman, J. C., Pearce, F. L., Piotrowski, W. & Thastrup, Ole, 1985, In: British Journal of Pharmacology. 85, 3, p. 705-12 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      The antileishmanial activity of novel oxygenated chalcones and their mechanism of action

      Zhai, L., Chen, M., Blom, J., Theander, Thor Grundtvig, Christensen, Søren Brøgger & Kharazmi, A., 1999, In: Journal of Antimicrobial Chemotherapy. 43, 6, p. 793-803 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria

      Zhai, L., Blom, J., Chen, M., Christensen, Søren Brøgger & Kharazmi, A., 1995, In: Antimicrobial Agents and Chemotherapy. 39, 12, p. 2742-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed

      Ziegler, H. L., Hansen, Harald S., Stærk, Dan, Christensen, Søren Brøgger, Hägerstrand, H. & Jaroszewski, J. W., 2004, In: Antimicrobial Agents and Chemotherapy. 48, p. 4067-4071

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Published

      The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations

      Thastrup, Ole, Linnebjerg, H., Bjerrum, P. J., Knudsen, J. B. & Christensen, Søren Brøgger, 1987, In: BBA General Subjects. 927, 1, p. 65-73 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol

      Kady, M. M., Brimer, L., Furu, Peter, Lemmich, E., Nielsen, H. M., Thiilborg, S. T., Thastrup, Ole & Christensen, Søren Brøgger, 1992, In: Planta Medica. 58, 4, p. 334-7 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Published

      The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo

      Chen, M., Christensen, Søren Brøgger, Zhai, L., Rasmussen, M. H., Theander, Thor Grundtvig, Frøkjær, Sven, Steffansen, B., Davidsen, J. & Kharazmi, A., 1997, In: Journal of Infectious Diseases. 176, 5, p. 1327-33 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Published

      The pharmacophore of thapsigargin

      Christensen, Søren Brøgger, Skytte, D. M., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M. & Møller, J. V., Aug 2010, In: Planta Medica. 76, 12, p. 1187

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    78. Published

      The potencies of thapsigargin and analogues as activators of rat peritoneal mast cells

      Norup, E., Smitt, U. W. & Christensen, Søren Brøgger, 1 Jan 1986, In: Planta Medica. NO. 4, p. 251-255 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      Toxicodynamics of tumour promoters of mouse skin III. Specific binding of the tumour promoter thapsigargin as measured by the cold-acetone filter assay

      Christensen, Søren Brøgger, Hergenhahn, M., Roeser, H. & Hecker, E., 1 May 1992, In: Journal of Cancer Research and Clinical Oncology. 118, 5, p. 344-348 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Published

      Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx

      Oketch-Rabah, H. A., Lemmich, E., Dossaji, S. F., Theander, Thor Grundtvig, Olsen, C. E., Cornett, Claus, Kharazmi, A. & Christensen, Søren Brøgger, 1997, In: Journal of Natural Products. 60, 5, p. 458-61 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Published

      Validation of anti-malarial leads from natural products and traditional medicine for treatment of malaria

      Christensen, Søren Brøgger, 2022, In Evidence-Based validation of herbal medicine. Mukherjee, P. K. (ed.). 2 ed. Amsterdam: Elsevier, p. 389-407

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    82. Published

      Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase

      Paulsen, E. S., Villadsen, J., Tenori, E., Liu, Huizhen, Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C. L., Autzen, Henriette Elisabeth, Dach, I., Sehgal, P., Nissen, P., Møller, J., Schiøtt, B. & Christensen, Søren Brøgger, 9 May 2013, In: Journal of Medicinal Chemistry. 56, 9, p. 3609-19 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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