Søren Brøgger Christensen

Søren Brøgger Christensen

Professor emeritus, Professor, emeritus

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    ORCID: 0000-0002-5773-6874

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    1. Published

      Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase

      Paulsen, E. S., Villadsen, J., Tenori, E., Liu, Huizhen, Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C. L., Autzen, Henriette Elisabeth, Dach, I., Sehgal, P., Nissen, P., Møller, J., Schiøtt, B. & Christensen, Søren Brøgger, 9 May 2013, In: Journal of Medicinal Chemistry. 56, 9, p. 3609-19 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Validation of anti-malarial leads from natural products and traditional medicine for treatment of malaria

      Christensen, Søren Brøgger, 2022, In Evidence-Based validation of herbal medicine. Mukherjee, P. K. (ed.). 2 ed. Amsterdam: Elsevier, p. 389-407

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    3. Published

      Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx

      Oketch-Rabah, H. A., Lemmich, E., Dossaji, S. F., Theander, Thor Grundtvig, Olsen, C. E., Cornett, Claus, Kharazmi, A. & Christensen, Søren Brøgger, 1997, In: Journal of Natural Products. 60, 5, p. 458-61 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Toxicodynamics of tumour promoters of mouse skin III. Specific binding of the tumour promoter thapsigargin as measured by the cold-acetone filter assay

      Christensen, Søren Brøgger, Hergenhahn, M., Roeser, H. & Hecker, E., 1 May 1992, In: Journal of Cancer Research and Clinical Oncology. 118, 5, p. 344-348 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      The potencies of thapsigargin and analogues as activators of rat peritoneal mast cells

      Norup, E., Smitt, U. W. & Christensen, Søren Brøgger, 1 Jan 1986, In: Planta Medica. NO. 4, p. 251-255 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      The pharmacophore of thapsigargin

      Christensen, Søren Brøgger, Skytte, D. M., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M. & Møller, J. V., Aug 2010, In: Planta Medica. 76, 12, p. 1187

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    7. Published

      The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo

      Chen, M., Christensen, Søren Brøgger, Zhai, L., Rasmussen, M. H., Theander, Thor Grundtvig, Frøkjær, Sven, Steffansen, B., Davidsen, J. & Kharazmi, A., 1997, In: Journal of Infectious Diseases. 176, 5, p. 1327-33 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol

      Kady, M. M., Brimer, L., Furu, Peter, Lemmich, E., Nielsen, H. M., Thiilborg, S. T., Thastrup, Ole & Christensen, Søren Brøgger, 1992, In: Planta Medica. 58, 4, p. 334-7 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations

      Thastrup, Ole, Linnebjerg, H., Bjerrum, P. J., Knudsen, J. B. & Christensen, Søren Brøgger, 1987, In: BBA General Subjects. 927, 1, p. 65-73 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed

      Ziegler, H. L., Hansen, Harald S., Stærk, Dan, Christensen, Søren Brøgger, Hägerstrand, H. & Jaroszewski, J. W., 2004, In: Antimicrobial Agents and Chemotherapy. 48, p. 4067-4071

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria

      Zhai, L., Blom, J., Chen, M., Christensen, Søren Brøgger & Kharazmi, A., 1995, In: Antimicrobial Agents and Chemotherapy. 39, 12, p. 2742-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      The antileishmanial activity of novel oxygenated chalcones and their mechanism of action

      Zhai, L., Chen, M., Blom, J., Theander, Thor Grundtvig, Christensen, Søren Brøgger & Kharazmi, A., 1999, In: Journal of Antimicrobial Chemotherapy. 43, 6, p. 793-803 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response

      Ali, H., Christensen, Søren Brøgger, Foreman, J. C., Pearce, F. L., Piotrowski, W. & Thastrup, Ole, 1985, In: British Journal of Pharmacology. 85, 3, p. 705-12 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L

      Rasmussen, U., Christensen, Søren Brøgger & Sandberg, F., 1 Jan 1978, In: Acta Pharmaceutica Suecica. 15, 2, p. 133-140 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Thapsigargin-induced increase in cytoplasmic Ca2+concentration and aldosterone production in rat adrenal glomerulosa cells: Interaction with potassium and angiotensin-II

      Hajnóczky, G., Várnai, P., Holló, Z., Christensen, Søren Brøgger, Balla, T., Enyedi, P. & Spät, A., 1 May 1991, In: Endocrinology. 128, 5, p. 2639-2644 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development.

      Doan, T. Q. N. & Christensen, Søren Brøgger, Oct 2015, In: Current Pharmaceutical Design. 21, 38, p. 5505-5517 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    17. Published

      Thapsigargin, constitution of a sesquiterpene lactone histamine liberator from thapsia garganica

      Christensen, Søren Brøgger, Rasmussen, U. & Christophersen, C., 1980, In: Tetrahedron Letters. 21, 39, p. 3829-3830 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis

      Hakii, H., Fujiki, H., Suganuma, M., Nakayasu, M., Tahira, T., Sugimura, T., Scheuer, P. J. & Christensen, Søren Brøgger, 1 Jun 1986, In: Journal of Cancer Research and Clinical Oncology. 111, 3, p. 177-181 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Thapsigargin affinity purification of intracellular P2A-type Ca2+ ATPases

      Vandecaetsbeek, I., Christensen, Søren Brøgger, Liu, Huizhen, van Veldhoven, P. P., Waelkens, E., Eggermont, J., Raeymaekers, L., Møller, J. V., Nissen, P., Wuytack, F. & Vangheluwe, P., 1 May 2011, In: BBA General Subjects. 1813, 5, p. 1118-1127

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Thapsigargin: a novel molecular probe for studying intracellular calcium release and storage

      Thastrup, Ole, Dawson, A. P., Scharff, O., Foder, B., Cullen, P. J., Drøbak, B. K., Bjerrum, P. J., Christensen, Søren Brøgger & Hanley, M. R., 1994, In: Agents and Actions. 43, 3-4, p. 187-93 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Targeting thapsigargin towards tumors

      Christensen, Søren Brøgger, Doan, T. Q. N., Paulsen, E. S., Sehgal, P., Møller, J. V., Nissen, P., Denmeade, S. R., Isaacs, J. T. & Dionne, C. A., 2015, In: Steroids. 97, p. 2-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Targeting Toxins toward Tumors

      Franzyk, Henrik & Christensen, Søren Brøgger, 2021, In: Molecules. 26, 5, 23 p., 1292.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Synthesis, isolation and identification of glucuronides and mercapturic acids of a novel antiparasitic agent, licochalcone A

      Nadelmann, L., Tjornelund, J., Hansen, S. H., Cornett, Claus, Sidelmann, U. G., Braumann, U., Christensen, E. & Christensen, Søren Brøgger, 1997, In: Xenobiotica. 27, 7, p. 667-680 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Synthesis of the thapsigargins

      Ley, S. V., Antonello, A., Balskus, E. P., Booth, D. T., Christensen, Søren Brøgger, Cleator, E., Gold, H., Högenauer, K., Hünger, U., Myers, R. M., Oliver, S. F., Simic, O., Smith, M. D., Søhoel, H. & Woolford, A. J. A., 17 Aug 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 33, p. 12073-12078 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Synthesis of antiparasitic licorice chalcones

      Nielsen, S. F., Chen, M., Theander, Thor Grundtvig, Kharazmi, A. & Christensen, Søren Brøgger, 1995, In: Bioorganic & Medicinal Chemistry Letters. 5, p. 449-452 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Syntheses of 11-hydroxylated guaianolides

      Lauridsen, A., Cornett, Claus, Vulpius, T., Moldt, P. & Christensen, Søren Brøgger, 1996, In: Acta Chemica Scandinavica. Supplementum. 50, 2, p. 150-157 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Synergistic stimulation of histamine release from rat peritoneal mast cells by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters

      Ohuchi, K., Hirasawa, N., Takahashi, C., Watanabe, M., Tsurufuji, S., Fujiki, H., Suganuma, M., Hakii, H., Sugimura, T. & Christensen, Søren Brøgger, 16 Jun 1986, In: BBA - Molecular Cell Research. 887, 1, p. 94-99 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+-Transport ATPase (SPCA1a)

      Jialin, C., de Raeymaecker, J., Hovgaard, J. B., Smaardijk, S., Vandecaetsbeek, I., Wuytack, F., Møller, J. V., Eggermont, J., de Meyer, M., Christensen, Søren Brøgger & Vangheluwe, P., 2017, In: Journal of Biological Chemistry. 292, 17, p. 6938-6951 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida

      Sittie, A. A., Lemmich, E., Olsen, C. E., Hviid, Lars, Kharazmi, A., Nkrumah, F. K. & Christensen, Søren Brøgger, 1999, In: Planta Medica. 65, 3, p. 259-61 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Structure-activity relationships of thapsigargin

      Nielsen, S. F., Andersen, A., Olsen, C. E., Treimann, M., Thastrup, Ole & Christensen, Søren Brøgger, 1 Dec 1993, In: Planta Medica. 59, 7 SUPPL., p. A678-A679

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Structure-activity relationships of analogues of thapsigargin modified at O-11 and O-12

      Nielsen, S. F., Thastrup, Ole, Pedersen, R., Olsen, C. E. & Christensen, Søren Brøgger, 1995, In: Journal of Medicinal Chemistry. 38, 2, p. 272-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

      Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Structure of histamine releasing guaianolides from Thapsia species

      Christensen, Søren Brøgger, Norup, E., Rasmussen, U. & Øgaard Madsen, J., 1984, In: Phytochemistry. 23, 8, p. 1659-1663 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Structure and biological activity of sesquiterpene lactones from Thapsia species and of analogue derivatives

      Rasmussen, U., Christensen, Søren Brøgger & Patkar, S. A., 1 Jan 1982, In: Planta Medica. 45, 3, p. P23

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Structural elucidation and partial synthesis of 3-hydroxyheterodendrin, a cyanogenic glucoside from Acacia sieberiana var. woodii

      Brimer, L., Christensen, Søren Brøgger, Jaroszewski, J. W. & Nartey, F., 1981, In: Phytochemistry. 20, 9, p. 2221-2223 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Stimulation of arachidonic acid metabolism in rat peritoneal macrophages by thapsigargin, a non-(12-O-tetradecanoylphorbol-13-acetate) (TPA)-type tumor promoter

      Ohuchi, K., Sugawara, T., Watanabe, M., Hirasawa, N., Tsurufuji, S., Fujiki, H., Sugimura, T. & Christensen, Søren Brøgger, 1 Jun 1987, In: Journal of Cancer Research and Clinical Oncology. 113, 4, p. 319-324 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Sesquiterpenoids from Thapsia species and medicinal chemistry of the thapsigargins.

      Christensen, Søren Brøgger, Andersen, A. & Smitt, U. W., 1997, In: Fortschritte der Chemie organischer Naturstoffe. Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles. 71, p. 129-167 39 p.

      Research output: Contribution to journal › Review › Research › peer-review

    38. Published

      Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

      Rubal, J. J., Guerra, F. M., Moreno-Dorado, F. J., Jorge, Z. D., Massanet, G. M., Søhoel, H., Smitt, U. W., Frydenvang, Karla Andrea, Christensen, Søren Brøgger, Nielsen, C. & Eriksson, M., 2006, In: Journal of Natural Products. 69, 11, p. 1566-71 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)

      Stafford, G. I., Birer, C., Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H., Jäger, A. & Rønsted, Nina, Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer

      Janssen, S., Jakobsen, C. M., Rosen, D. M., Ricklis, R. M., Reineke, U., Christensen, Søren Brøgger, Lilja, H. & Denmeade, S. R., 1 Nov 2004, In: Molecular Cancer Therapeutics. 3, 11, p. 1439-1450 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN

      Andersen, A., Cornett, Claus, Lauridsen, A., Olsen, C. E. & Christensen, Søren Brøgger, 1994, In: Acta Chemica Scandinavica. Supplementum. 48, 4, p. 340-346 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis

      Sheykhzade, Majid, Smajilovic, S., Issa, A., Haunsø, Stig, Christensen, Søren Brøgger & Tfelt-Hansen, J., 28 Sep 2008, In: European Journal of Pharmacology. 593, 1-3, p. 79-86

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Psychotropic constituents of Mentha aquatica L.

      Van Staden, J., Stafford, G. ,. I., Almqvist, J. P., Vangsoe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A. & Jäger, A., Aug 2007, In: Planta Medica. 73, 9, p. 928-929

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Psychotropic constituents of Mentha aquatica L.

      van Staden, J., Stafford, G. I., Almqvist, J. P., Vangsøe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A. & Jäger, A. K., 2007.

      Research output: Contribution to conference › Poster › Research

    45. Published

      Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer

      Denmeade, S. R., Jakobsen, C. M., Janssen, S., Khan, S. R., Garrett, E. S., Lilja, H., Christensen, Søren Brøgger & Isaacs, J. T., 2 Jul 2003, In: National Cancer Institute. Journal (Online). 95, 13, p. 990-1000 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Proacaciberin, A cyanogenic glycoside from Acacia sieberiana var. Woodii

      Nartey, F., Brimer, L. & Christensen, Søren Brøgger, 1981, In: Phytochemistry. 20, 6, p. 1311-1314 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Preparations of deuterium labelled guvacine and isoguvacine

      Christensen, Søren Brøgger & Krogsgaard-Larsen, Povl, 1 Jan 1980, In: Journal of Labelled Compounds and Radiopharmaceuticals. 17, 2, p. 191-202 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

      Zimmermann, T., Christensen, Søren Brøgger & Franzyk, Henrik, 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Prenylated acetophenones from Melicope obscura and Melicope obtusifolia ssp. obtusifolia var. arborea and their distribution in Rutaceae

      Adsersen, A., Smitt, U. W., Simonsen, H. T., Christensen, Søren Brøgger & Jaroszewski, J. W., 2007, In: Biochemical Systematics and Ecology. 35, 7, p. 447-453

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Planternes slægtskab som skattekort til nye lægemidler

      Rønsted, Nina, Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H. & Jäger, A. K., Dec 2010, In: Lægemiddelforskning. 2010, p. 19-21

      Research output: Contribution to journal › Journal article › Communication

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