Søren Brøgger Christensen

Søren Brøgger Christensen

Professor emeritus, Professor, emeritus

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    ORCID: 0000-0002-5773-6874

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    1. Published

      Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection

      Jensen, H. D., Struve, C., Christensen, Søren Brøgger & Krogfelt, K. A., 4 Apr 2017, In: Frontiers in Microbiology. 8, 6 p., 542.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs

      Winther, A. L., Liu, Huizhen, Sonntag, Y., Olesen, C., le Maire, M., Søhoel, H., Olsen, C. E., Christensen, Søren Brøgger, Nissen, P. & Møller, J. V., 2010, In: Journal of Biological Chemistry. 285, 37, p. 28883-28892

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Cyclic AMP- and inositol phosphate-independent inhibition of Ca2+ influx by cholera toxin in CDS-stimulated jurkat T cells: A study with a cholera toxin-resistant cell variant and the Ca2+ endoplasmic reticulum-ATPase inhibitor thapsigargin

      Gouy, H., Cefai, D., Christensen, Søren Brøgger, Debre, P. & Bismuth, G., 1 Aug 1991, In: Journal of Immunology. 147, 3, p. 757-766 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Cytotoxic kurubasch aldehyde from Trichilia emetica

      Traore, M., Zhai, L., Chen, M., Olsen, C. E., Odile, N., Pierres, G. I., Bosco, O. J., Robert, G. T. & Christensen, Søren Brøgger, 2007, In: Natural Product Reports. 21, 1, p. 13-17

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

      Liu, Huizhen, Jensen, K. G., Tran, L. M., Chen, M., Zhai, L., Olsen, C. E., Søhoel, H., Denmeade, S. R., Issacs, J. T. & Christensen, Søren Brøgger, 2006, In: Phytochemistry. 67, 24, p. 2651-2658 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life

      Dao, T. T., Sehgal, P., Thanh Tung, T., Møller, J. V., Nielsen, J., Palmgren, Michael, Christensen, Søren Brøgger & Fuglsang, Anja Thoe, 2016, In: P L o S One. 11, 9, 19 p., e0163260.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Derivatives of thapsigargin as probes of its binding site on endoplasmic reticulum Ca2+ ATPase. Stereoselectivity and important functional groups

      Christensen, Søren Brøgger, Andersen, A., Poulsen, J. C. J. & Treiman, M., 13 Dec 1993, In: FEBS Letters. 335, 3, p. 345-348 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium

      Christensen, Søren Brøgger, Dubois, C., Abeele, F. V., Sehgal, P., Olesen, C., Junker, S., Prevarskaya, N. & Møller, J. V., 2013, In: F E B S Journal. 280, 21, p. 5430-5440 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds

      Thanh Tung, T., Christensen, Søren Brøgger & Nielsen, J., 11 Oct 2017, In: Chemistry: A European Journal. 23, p. 18125-18128

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds - Scope, Limitations and Perspectives

      Nielsen, J., Christensen, Søren Brøgger & Tung, T. T., Dec 2018, In: Synthesis. 50, 23, p. A193-A196 4 p.

      Research output: Contribution to journal › Conference article › Research › peer-review

    11. Published

      Dimethyl sulfoxide decreases the fluorescence yield of the reaction between histamine and ortho-phthalaldehyde and may influence histamine release

      Moldt, P., Andersen, W. K. & Christensen, Søren Brøgger, 1 Jun 1988, In: Agents and Actions. 24, 1-2, p. 35-39 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Direct difluoromethylation of heterocycles using difluoroacetic acid

      Nielsen, J., Truong Thanh Tung & Christensen, Søren Brøgger, 19 Aug 2018.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    13. Published

      Discovery of oxygenated chalcoes as novel antimalarial agents

      Kharazmi, A., Chen, M., Theander, Thor Grundtvig & Christensen, Søren Brøgger, 1997, In: Annals of Tropical Medicine and Parasitology. 91, p. S91-S95 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Discovery of oxygentade chalcones as novel antimalarial agents

      Kharazmi, A., Chen, M., Theander, Thor Grundtvig & Christensen, Søren Brøgger, 1997, In: Annals of Tropical Medicine and Parasitology. 91, SUPPL. 1, p. S91-S95

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides

      Christensen, Søren Brøgger, 2022, In: Molecules. 27, 17, 29 p., 5648.

      Research output: Contribution to journal › Review › Research › peer-review

    16. Published

      Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams

      Christensen, Søren Brøgger, 2021, In: Molecules. 26, 19, 31 p., 6057.

      Research output: Contribution to journal › Review › Research › peer-review

    17. Published

      Drugs and drug leads based on natural products for treatment and prophylaxis of malaria

      Christensen, Søren Brøgger, 25 Feb 2015, Evidence-based validation of herbal medicine: Elsevier. Amsterdam, p. 307-319

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    18. Published

      Drugs for the neglected disease malaria based on natural products

      Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 1 Jan 2011, Bioactive Compounds from Natural Sources: Natural Products as Lead Compounds in Drug Discovery, Second Edition. CRC Press, p. 525-550 26 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    19. Published

      Drugs for the neglected disease malaria based on natural products

      Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2012, Bioactive compounds from natural sources: natural products as lead compounds in drug discovery. Tringali, C. (ed.). 2 ed. Boca Raton: CRC Press, p. 525-550

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    20. Published

      Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relation to AIDS

      Scharff, O., Foder, B., Thastrup, Ole, Hofmann, B., Møller, J., Ryder, L. P., Jacobsen, K. D., Langhoff, E., Dickmeiss, E. & Christensen, Søren Brøgger, 1988, In: BBA General Subjects. 972, 3, p. 257-64 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Effects of thapsigargin in isolated rat thoracic aorta

      Mikkelsen, E. O., Thastrup, Ole & Christensen, Søren Brøgger, 1988, In: Pharmacology & Toxicology. 62, 1, p. 7-11 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase

      Skytte, D. M., Møller, J. V., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M., Olsen, C. E. & Christensen, Søren Brøgger, 2010, In: Bioorganic & Medicinal Chemistry. 18, 15, p. 5634-5646 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy

      Denmeade, S. R., Mhaka, A. M., Rosen, D. M., Brennen, W. N., Dalrymple, S., Dach, I., Olesen, C., Gurel, B., DeMarzo, A. M., Wilding, G., Carducci, M. A., Dionne, C. A., Møller, J. V., Nissen, P., Christensen, Søren Brøgger & Isaacs, J. T., 27 Jun 2012, In: Science Translational Medicine. 4, 140, p. 140ra86

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy (Science Translational Medicine)

      Denmeade, S. R., Mhaka, A. M., Rosen, D. M., Brennen, W. N., Dalrymple, S., Dach, I., Olesen, C., Gurel, B., DeMarzo, A. M., Wilding, G., Carducci, M. A., Dionne, C. A., Møller, J. V., Nissen, Poul, Christensen, Søren Brøgger & Isaacs, J. T., 18 Jul 2012, In: Science Translational Medicine. 4, 143, 143er4.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    25. Published

      Evaluation of Medicinal Plants from Chile

      Simonsen, H. T., Guzman, A., Adsersen, A., Christensen, Søren Brøgger & Mølgaard, Per, 2008.

      Research output: Contribution to conference › Conference abstract for conference › Research

    26. Published

      Exciton Coupling in Circular Dichroic Spectroscopy as a Tool for Establishing the Absolute Configuration of alpha,beta-Unsaturated Esters of Allylic Alcohols

      Lauridsen, A., Cornett, Claus & Christensen, Søren Brøgger, 1991, In: Acta Chemica Scandinavica. Supplementum. 45, 1, p. 56-62 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development

      Christensen, Søren Brøgger, Simonsen, H. T., Engedal, N., Nissen, P., Møller, J. V., Denmeade, S. R. & Isaacs, J. T., 2021, In: Progress in the chemistry of organic natural products. 115, p. 59-114

      Research output: Contribution to journal › Review › Research › peer-review

    28. Published

      Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors

      Thanh Tung, T., Jakobsen, Tim Holm, Dao, T. T., Fuglsang, Anja Thoe, Givskov, Michael, Christensen, Søren Brøgger & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis

      Simonsen, H. T., Weitzel, C. & Christensen, Søren Brøgger, 2013, Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. Ramawat, K. G. & Mérillon, J-M. (eds.). Springer, p. 3069-3098 30 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    30. Published

      HYDROINDENE SESQUITERPENES FROM THAPSIA-VILLOSA

      Smitt, U. W., Cornett, Claus, Norup, E. & Christensen, Søren Brøgger, 1990, In: Phytochemistry. 29, 3, p. 873-875 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Hydrophilic carboxylic acids and iridoid glycosides in the juice of American and European cranberries (Vaccinium macrocarpon and V. oxycoccos), lingonberries (V. vitis-idaea), and blueberries (V. myrtillus)

      Jensen, H. D., Krogfelt, K. A., Cornett, Claus, Hansen, S. H. & Christensen, Søren Brøgger, 2002, In: Journal of Agricultural and Food Chemistry. 50, 23, p. 6871-4 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis

      Kvist, L. P., Christensen, Søren Brøgger, Rasmussen, H. B., Mejia, K. & Gonzalez, Ana Valeria, 19 Jul 2006, In: Journal of Ethnopharmacology. 106, 3, p. 390-402 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Identification of natural products using HPLC-SPE combined with CapNMR

      Lambert, M., Wolfender, J., Stærk, Dan, Christensen, Søren Brøgger, Hostettmann, K. & Jaroszewski, J. W., 2007, In: Analytical Chemistry. 79, 2, p. 727-735

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

      Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Iminolactones from Schizophyllum commune

      Liu, X., Frydenvang, Karla Andrea, Liu, H., Zhai, L., Chen, M., Olsen, C. E. & Christensen, Søren Brøgger, 2015, In: Journal of Natural Products. 78, 5, p. 1165-1168 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Incorporation of the Cross Fire Beilstein database in the organic chemistry curriculum at the Royal Danish School of Pharmacy

      Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 2002, In: Journal of Chemical Education. 79, p. 765-768

      Research output: Contribution to journal › Journal article › Research

    37. Published

      Incorporation of the crossfire Beilstein database into the organic chemistry curriculum at the Royal Danish School of Pharmacy

      Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 1 Jun 2002, In: Journal of Chemical Education. 79, 6, 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones

      Chen, M., Zhai, L., Christensen, Søren Brøgger, Theander, Thor Grundtvig & Kharazmi, A., 2001, In: Antimicrobial Agents and Chemotherapy. 45, 7, p. 2023-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response

      Sehgal, P., Szalai, P., Praetorius, H. A., Nissen, Poul, Christensen, Søren Brøgger, Engedal, N. & Møller, J. V., 2 Oct 2017, In: Journal of Biological Chemistry. 292, 48, p. 19656-19673

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain

      Verma, A., Hirsch, D. J., Hanley, M. R., Thastrup, O., Christensen, Søren Brøgger & Snyder, S. H., 1990, In: Biochemical and Biophysical Research Communications. 172, 2, p. 811-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam.) Exell.

      Khalid, S. A., Friedrichsen, G. M., Christensen, Søren Brøgger, El Tahir, A. & Satti, G. M., 2007, In: Arkivoc. ix, p. 129-134

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam.) Exell.

      Khalid, S. A., Friedrichsen, G. M., Christensen, Søren Brøgger, El Tahir, A. & Satti, G. M., 29 Jan 2007, In: ARKIVOC. 2007, 9, p. 129-134 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

      Saaby, Lasse, Jäger, A. K., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Feb 2011, In: Phytotherapy Research. 25, 2, p. 195-201

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip

      Jäger, A., Petersen, K. N., Thomasen, G. & Christensen, Søren Brøgger, 2008, In: Phytotherapy Research. 22, 7, p. 982-984 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Isolation of the MAO-inhibitor naringenin from Mentha aquatica L

      Olsen, H. T., Stafford, G. I., van Staden, J., Christensen, Søren Brøgger & Jäger, A. K., 2008, In: Journal of Ethnopharmacology. 117, 3, p. 500-502

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Isolation of tow high-polar fractions from 'Banlangen', root of isatis tinctoria L. and its activity

      Qin, Q., He, H. P., Christensen, Søren Brøgger, Rasmussen, H. B., Kharazmi, A. & Chen, M., 1 Jan 2001, In: Chinese Pharmacological Bulletin. 17, 6, p. 714-715 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Isorhamnetin3-(2,6-dirhamnosylgalactoside)-7-rhamnoside and 3-(6-rhamnosylgalactoside)-7-rhamnoside from Rhazya stricta

      Andersen, W. K., Omar, A. A. & Christensen, Søren Brøgger, 23 Dec 1986, In: Phytochemistry. 26, 1, p. 291-294 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      LEGO-inspired drug design: unveiling a class of Benzo[d]thiazoles containing a 3,4-Dihydroxyphenyl moiety as plasma membrane H+-ATPase inhibitors

      Thanh Tung, T., Dao, T. T., Grifell Junyent, M., Palmgren, Michael, Pomorski, Thomas Guenther, Fuglsang, Anja Thoe, Christensen, Søren Brøgger & Nielsen, J., 2018, In: ChemMedChem. 13, 1, 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      LEGO-inspired drug design: Discovery of novel fungal Plasma membrane H+-ATPase (Pma1) inhibitors from small molecule libraries: An introduction of HFSA-SBS_DOS-RD strategy in drug discovery.

      Tung, T. T., Dao, T. T., Palmgren, M. B., Fuglsang, A. T., Christensen, Søren Brøgger & Nielsen, J., 2 Apr 2017.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    50. Published

      Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-O-(12-Aminododecanoyl)- 8-O-Debutanoylthapsigargin

      Zimmermann, T., Drasar, P., Rempelova, S., Christensen, Søren Brøgger, Khripach, V. & Jurasek, M., 2020, In: Biomolecules. 10, 11 p., 1640.

      Research output: Contribution to journal › Journal article › Research › peer-review

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