Trond Ulven

Trond Ulven

Professor

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    ORCID: 0000-0002-8135-1755

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    1. Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy

      Hansen, S. V. F., Ulven, Elisabeth Rexen, Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G. & Ulven, Trond, 1 Mar 2016, In: Journal of Medicinal Chemistry. 59, 6, p. 2841-2846 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties

      Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2018, In: Journal of Medicinal Chemistry. 61, 21, p. 9534-9550 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Discovery of a potent and selective GPR120 agonist

      Shimpukade, B., Hudson, B. D., Hovgaard, C. K., Milligan, G. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 9, p. 4511-4515 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schmidt, J., Hansen, S. V. F., Hudson, B. D., Zaibi, M., Markussen, S. B., Hagesaether, E., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 982-992 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes

      Ulven, Elisabeth Rexen, Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A. D., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 27 Nov 2008, In: Journal of Medicinal Chemistry. 51, 22, p. 7061-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120

      Prihandoko, R., Alvarez-Curto, E., Hudson, B. D., Butcher, A. J., Ulven, Trond, Miller, A. M., Tobin, A. B. & Milligan, G., 2016, In: Molecular Pharmacology. 89, 5, p. 505-520 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Drug Repurposing in Crohn's Disease Using Danish Real-World Data

      Shakibfar, Saeed, Allin, K. H., Jess, T., Barbieri, M. A., Battini, V., Simoncic, E., Kirchgesner, J., Ulven, Trond & Sessa, Maurizio, 2024, In: Pragmatic and observational research. 15, p. 17-29

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Effects of delayed-release olive oil and hydrolyzed pine nut oil on glucose tolerance, incretin secretion and appetite in humans

      Sørensen, K. V., Kaspersen, M. H., Ekberg, J. H., Bauer-Brandl, A., Ulven, Trond & Højlund, K., 2021, In: Nutrients. 13, 10, 13 p., 3407.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Efficient Synthesis of 4,7-Diamino Substituted 1,10-Phenanthroline-2,9-dicarboxamides

      Larsen, A. F. & Ulven, Trond, 2011, In: Organic Letters. 13, 13, p. 3546-3548 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Emerging roles of DP and CRTH2 in allergic inflammation

      Kostenis, E. & Ulven, Trond, 2006, In: Trends in Molecular Medicine. 12, 4, p. 148-158 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Ethyl 2-(1,2,3,4-tetrahydrospiro[carbazole-3,2'- [1,3]dioxolan]-9-yl)acetate

      Loffler, P., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, Section E, p. o685

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3

      Hudson, B. D., Tikhonova, I. G., Pandey, S. K., Ulven, Trond & Milligan, G., 2012, In: Journal of Biological Chemistry. 287, 49, p. 41195-41209 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Extracellular loop 2 of the free Fatty Acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator

      Smith, N. J., Ward, R. J., Stoddart, L. A., Hudson, B. D., Kostenis, E., Ulven, Trond, Morris, J. C., Tränkle, C., Tikhonova, I. G., Adams, D. R. & Milligan, G., 2011, In: Molecular Pharmacology. 80, 1, p. 163-173 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Extraction of G-quadruplex ligands from disulfide-based dynamic combinatorial libraries

      Nielsen, Mads & Ulven, Trond, 2009, p. ORGN-345.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    15. Published

      FFA1/Gq - Gi interaction determines glucose-induced insulin secretion of neonatal beta cells

      Gerst, F., Lorza-Gil, E., Kaiser, G., Ulven, Trond, Kostenis, E., Haring, H. -., Birkenfeld, A. L. & Ullrich, S., 2022, In: Diabetologia. 65, Suppl 1, p. S109-S109

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    16. Published

      FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

      Lorza-Gil, E., Kaiser, G., Ulven, Elisabeth Rexen, Koenig, G. M., Gerst, F., Oquendo, M. B., Birkenfeld, A. L., Haering, H., Kostenis, E., Ulven, Trond & Ullrich, S., 2020, In: Scientific Reports. 10, 1, 11 p., 16497.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance

      Houthuijzen, J. M., Oosterom, I., Hudson, B. D., Hirasawa, A., Daenen, L. G. M., McLean, C. M., Hansen, S. V. F., van Jaarsveld, M. T. M., Peeper, D. S., Jafari Sadatmand, S., Roodhart, J. M. L., van de Lest, C. H. A., Ulven, Trond, Ishihara, K., Milligan, G. & Voest, E., 2017, In: F A S E B Journal. 31, 5, p. 2195-2209 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Flow chemistry methods for the synthesis chemokine receptor ligands

      Petersen, T. P., Ritzén, A. & Ulven, Trond, 2009, p. ORGN-570.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    19. Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schröder, R., Hudson, B. D., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 14, p. 6624-6628 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Functional-Group-Tolerant Pd-Catalyzed Carbonylative Negishi Coupling with Aryl Iodides

      Kalinin, D. V. & Ulven, Trond, 2023, In: Journal of Organic Chemistry. 88, 23, p. 16633-16638

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      G protein-coupled receptor modulators and a pharmaceutical composition

      Ulven, Trond & Ieremias, L., 2021, IPC No. A61K31/44, A61P25/00, A61P29/00, C07D213/69, C07D405/12, Patent No. WO 2021/123394 A1, 18 Dec 2020, Priority date 20 Dec 2019, Priority No. EP20150090A

      Research output: Patent

    22. G-protein-coupled receptors for free fatty acids

      Milligan, G., Ulven, Trond, Murdoch, H. & Hudson, B. D., 2 Jan 2014, In: British Journal of Nutrition. 111, Supplement S1, p. S3-S7

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      GPR120 receptor modulators

      Ulven, Trond & Shimpukade, B., 26 Sep 2013, Patent No. WO 2013/139341 A1

      Research output: Patent

    24. Published

      GPR120 receptor modulators

      Ulven, Trond & Shimpukade, B., 19 Dec 2013, Patent No. WO 2013/185766 A1

      Research output: Patent

    25. Published

      Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets

      Lorza-Gil, E., Kaiser, G., Carlein, C., Hoffmann, M. D. A., König, G. M., Haug, S., Prates Roma, L., Ulven, Elisabeth Rexen, Ulven, Trond, Kostenis, E., Birkenfeld, A. L., Häring, H. U., Ullrich, S. & Gerst, F., 2023, In: Diabetologia. 66, p. 1501–1515

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

      Sencio, V., Barthelemy, A., Tavares, L. P., Machado, M. G., Soulard, D., Cuinat, C., Queiroz-Junior, C. M., Noordine, M. L., Salomé-Desnoulez, S., Deryuter, L., Foligné, B., Wahl, C., Frisch, B., Vieira, A. T., Paget, C., Milligan, G., Ulven, T., Wolowczuk, I., Faveeuw, C., Le Goffic, R. & 4 others, Thomas, M., Ferreira, S., Teixeira, M. M. & Trottein, F., 3 Mar 2020, In: Cell Reports. 30, 9, p. 2934-2947.e6

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance

      Dragano, N. R. V., Milbank, E., Haddad-Tóvolli, R., Garrido-Gil, P., Nóvoa, E., Fondevilla, M. F., Capelli, V., Zanesco, A. M., Solon, C., Morari, J., Pires, L., Estevez-Salguero, Á., Beiroa, D., González-García, I., Barca-Mayo, O., Diéguez, C., Nogueiras, R., Labandeira-García, J. L., Rexen Ulven, E., Ulven, T. & 3 others, Claret, M., Velloso, L. A. & López, M., 2024, In: Molecular Metabolism. 79, 13 p., 101840.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library

      Yao, R., Jensen, Anders A., Bryce-Rogers, H. P., Schultz-Knudsen, Katrine, Zhou, L., Hovendal, N. P., Pedersen, H., Kubus, M., Ulven, Trond & Laraia, L., 2023, In: Journal of Medicinal Chemistry. 66, 16, p. 11536-11554

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties

      Ulven, Elisabeth Rexen, Urban, C., Grundmann, M., Due-Hansen, M. E., Hagesaether, E., Schmidt, J., Pardo, L., Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2011, In: Journal of Medicinal Chemistry. 54, 19, p. 6691-6703 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Identification of galectin-1 and other cellular targets of alpha,beta-unsaturated carbonyl compounds, including dimethylfumarate, by use of click-chemistry probes

      Sauerland, Max Benjamin, Helm, C., Lorentzen, Lasse Gøbel, Manandhar, Asmita, Ulven, Trond, Gamon, Luke Francis & Davies, Michael J., 2023, In: Redox Biology. 59, 15 p., 102560.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2

      Mathiesen, Jesper M., Ulven, Trond, Martin, L., Gerlach, L., Heinemann, A. & Kostenis, E., 2005, In: Molecular Pharmacology. 68, 2, p. 393-402 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469

      Urban, C., Hamacher, A., Partke, H. J., Roden, M., Schinner, S., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Ulven, Trond, Gohlke, H. & Kassack, M. U., 17 Jul 2013, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 386, 12, p. 1021-2030 1010 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Macrocyclic G-quadruplex ligands

      Nielsen, M. C. & Ulven, Trond, 1 Jan 2010, In: Current Medicinal Chemistry. 17, 29, p. 3438-3448 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Method of synthesizing a 5-oxo-conjugated fatty acid

      Ulven, Trond & Tyagi, R., 27 Oct 2011, Patent No. WO 2011/131619 A1

      Research output: Patent

    35. Published

      Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization

      Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Minor Structural Modifications Convert the Dual TP/CRTH2 Antagonist Ramatroban into a Highly Selective and Potent CRTH2 Antagonist

      Ulven, Trond & Kostenis, E., 2005, In: Journal of Medicinal Chemistry. 48, 4, p. 897-900 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors

      Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)

      Karlshøj, S., Amarandi, R. M., Larsen, Olav, Daugvilaite, V., Steen, A., Brvar, M., Pui, A., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 23 Dec 2016, In: Journal of Biological Chemistry. 291, 52, p. 26860-26874

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Mucus can change the permeation rank order of drug candidates

      Hagesaether, E., Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 2013, In: International Journal of Pharmaceutics. 452, 1-2, p. 276-282 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Multistep Continuous-Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure-Activity Relationships of CCR8 Ligands

      Petersen, T. P., Mirsharghi, S., Rummel, P. C., Thiele, S., Rosenkilde, Mette, Ritzén, A. & Ulven, Trond, 8 Jul 2013, In: Chemistry: A European Journal. 19, 28, p. 9343-50 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

      Goncalves de Azavedo, C. M. B. P., Watterson, K. R., Wargent, E. T., Hansen, S. V. F., Hudson, B. D., Kępczyńska, M. A., Dunlop, J., Shimpukade, B., Ulven, Elisabeth Rexen, Milligan, G., Stocker, C. J. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8868-8878 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands

      Sergeev, E., Hojgaard Hansen, A., Pandey, S. K., Mackenzie, A. E., Hudson, B. D., Ulven, Trond & Milligan, G., 2016, In: Journal of Biological Chemistry. 291, p. 303-317 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Novel CRTH2 antagonists: a review of patents from 2006 to 2009

      Ulven, Trond & Kostenis, E., 1 Nov 2010, In: Expert Opinion on Therapeutic Patents. 20, 11, p. 1505-1530 26 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice

      Murtaza, B., Hichami, A., Khan, A. S., Shimpukade, B., Ulven, Trond, Ozdener, M. H. & Khan, N. A., 2020, In: Journal of Lipid Research. 61, 2, p. 133-142 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Novel benzamide compounds for use in MCH receptor related disorders

      Högberg, T., Bjurling, A. E., Receveur, J., Ulven, Trond, Elling, C. E. & Nørregaard, P. K., 2004, Patent No. WO 2004/048319

      Research output: Patent

    46. Published

      Novel chemistry of alpha-tosyloxy ketones: applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries

      Nicolaou, K. C., Montagnon, T., Ulven, Trond, Baran, P. S., Zhong, Y. & Sarabia, F., 22 May 2002, In: American Chemical Society. Journal. 124, 20, p. 5718-5728 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits

      Ulven, Trond, Receveur, J., Grimstrup, M., Rist, Ø., Frimurer, Thomas Michael, Gerlach, L., Mathiesen, Jesper M., Kostenis, E., Uller, L. & Högberg, T., 2006, In: Journal of Medicinal Chemistry. 49, 23, p. 6638-6641 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1

      Rist, O., Grimstrup, M., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Kostenis, E. & Högberg, T., 4 Dec 2009, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1177-1180 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2

      Grimstrup, M., Rist, Ø., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Mathiesen, Jesper M., Kostenis, E. & Högberg, T., 1 Feb 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1181-1185 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      On the mechanism of interaction of potent, surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

      Mathiesen, Jesper M., Christopoulos, A., Ulven, Trond, Royer, J. F., Campillo, M., Heinemann, A., Pardo, L. & Kostenis, E., 2006, In: Molecular Pharmacology. 69, 4, p. 1441-1453 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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