Elisabeth Rexen Ulven

Elisabeth Rexen Ulven

Associate Professor

ORCID: 0000-0003-1243-7587

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  1. Published

    Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

    Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, Trond, Hudson, B. D., Ulven, Elisabeth Rexen, Dekker, N., Tobin, A. B. & Milligan, G., 2022, In: eLife. 11, 23 p., e73777.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Structure-activity study of dihydrocinnamic acids and discovery of the potent FFA1 (GPR40) agonist TUG-469

    Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Merten, N., Pfleiderer, M., Karlsen, K. K., Rasmussen, S. S., Steensgaard, M., Hamacher, A., Schmidt, J., Drewke, C., Petersen, R. K., Kristiansen, Karsten, Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2010, In: ACS Medicinal Chemistry Letters. 1, 7, p. 345-349 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  3. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties

    Ulven, Elisabeth Rexen, Urban, C., Grundmann, M., Due-Hansen, M. E., Hagesaether, E., Schmidt, J., Pardo, L., Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2011, In: Journal of Medicinal Chemistry. 54, 19, p. 6691-6703 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Discovery of TUG-770

    Ulven, Elisabeth Rexen, Hansen, S. V. F., Urban, C., Hudson, B. D., Wargent, E. T., Grundmann, M., Jenkins, L., Zaibi, M., Stocker, C. J., Ullrich, S., Kostenis, E., Kassack, M. U., Milligan, G., Cawthorne, M. A. & Ulven, Trond, 9 May 2013, In: A C S Medicinal Chemistry Letters. 4, 5, p. 441-445 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

    Ulven, Elisabeth Rexen, Hudson, B. D., Hansen, A. H., Milligan, G. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 10, p. 4849-4858 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes

    Ulven, Elisabeth Rexen, Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A. D., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 27 Nov 2008, In: Journal of Medicinal Chemistry. 51, 22, p. 7061-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists

    Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 19 Feb 2010, In: Journal of Organic Chemistry. 75, 4, p. 1301-1304 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

    Ulven, Elisabeth Rexen, Watterson, K. R., Stocker, C. J., Sokol, E., Jenkins, L., Simon, K., Grundmann, M., Petersen, R. K., Wargent, E. T., Hudson, B. D., Kostenis, E., Ejsing, C. S., Cawthorne, M. A., Milligan, G. & Ulven, T., 2015, In: British Journal of Nutrition. 113, 11, p. 1677-1688 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability

    Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schmidt, J., Hansen, S. V. F., Hudson, B. D., Zaibi, M., Markussen, S. B., Hagesaether, E., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 982-992 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists

    Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schröder, R., Hudson, B. D., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 14, p. 6624-6628 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Development and Characterization of Potent Succinate Receptor Fluorescent Tracers

    Ciba, Marija, Dibnah, B., Hudson, B. D. & Ulven, Elisabeth Rexen, 2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8951–8974

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum

    Domljanovic, I., Ulven, Elisabeth Rexen, Ulven, Trond, Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K., 31 Jul 2018, In: ACS Omega. 3, 7, p. 7580-7586 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

    Dragano, N. R. V., Solon, C., Ramalho, A. F., de Moura, R. F., Razolli, D. S., Ulven, Elisabeth Rexen, Goncalves de Azavedo, C. M. B. P., Ulven, Trond & Velloso, L. A., 2017, In: Journal of Neuroinflammation. 14, 91, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance

    Dragano, N. R. V., Milbank, E., Haddad-Tóvolli, R., Garrido-Gil, P., Nóvoa, E., Fondevilla, M. F., Capelli, V., Zanesco, A. M., Solon, C., Morari, J., Pires, L., Estevez-Salguero, Á., Beiroa, D., González-García, I., Barca-Mayo, O., Diéguez, C., Nogueiras, R., Labandeira-García, J. L., Rexen Ulven, E., Ulven, T. & 3 others, Claret, M., Velloso, L. A. & López, M., 2024, In: Molecular Metabolism. 79, 13 p., 101840.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

    Due-Hansen, M. E., Pandey, S. K., Ulven, Elisabeth Rexen, Andersen, R., Hansen, S. V. F. & Ulven, Trond, 2016, In: Organic & Biomolecular Chemistry. 14, 2, p. 430-433 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

    Goncalves de Azavedo, C. M. B. P., Watterson, K. R., Wargent, E. T., Hansen, S. V. F., Hudson, B. D., Kępczyńska, M. A., Dunlop, J., Shimpukade, B., Ulven, Elisabeth Rexen, Milligan, G., Stocker, C. J. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8868-8878 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Mucus can change the permeation rank order of drug candidates

    Hagesaether, E., Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 2013, In: International Journal of Pharmaceutics. 452, 1-2, p. 276-282 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2

    Hansen, A. H., Christensen, H. B., Pandey, S. K., Sergeev, E., Valentini, Alice, Dunlop, J., Dedeo, D., Fratta, S., Hudson, B. D., Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2021, In: ChemMedChem. 16, 21, p. 3326-3341

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties

    Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2018, In: Journal of Medicinal Chemistry. 61, 21, p. 9534-9550 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)

    Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2017, In: Journal of Medicinal Chemistry. 60, 13, p. 5638-5645 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy

    Hansen, S. V. F., Ulven, Elisabeth Rexen, Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G. & Ulven, Trond, 1 Mar 2016, In: Journal of Medicinal Chemistry. 59, 6, p. 2841-2846 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

    Hudson, B. D., Due-Hansen, M. E., Ulven, Elisabeth Rexen, Hansen, A., Mackenzie, A. E., Murdoch, H., Pandey, S. K., Ward, R. J., Marquez, R., Tikhonova, I. G., Ulven, Trond & Milligan, G., 14 Jun 2013, In: Journal of Biological Chemistry. 288, p. 17296-17312 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

    Hudson, B. D., Shimpukade, B., Mackenzie, A. E., Butcher, A. J., Pediani, J. D., Ulven, Elisabeth Rexen, Heathcote, H., Tobin, A. B., Ulven, Trond & Milligan, G., 2013, In: Molecular Pharmacology. 84, 5, p. 710-725 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

    Hudson, B. D., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, Trond & Milligan, G., 2012, In: F A S E B Journal. 26, 12, p. 4951-4965 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

    Hudson, B. D., Ulven, Elisabeth Rexen, Murdoch, H., Jenkins, L., Hansen, A. H., Madsen, O., Ulven, Trond & Milligan, G., Aug 2014, In: Molecular Pharmacology. 86, 2, p. 200-210 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 201719978