Trond Ulven
Professor
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1,2-Dihydrospiro[carbazole-3(4H),2'-[1,3]dioxolane]
Bjerrum, J. V., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, p. o579Research output: Contribution to journal › Journal article › Research › peer-review
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4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists
Receveur, J., Bjurling, E., Ulven, Trond, Little, P. B., Nørregaard, P. K. & Högberg, T., 18 Oct 2004, In: Bioorganic & Medicinal Chemistry Letters. 14, 20, p. 5075-5080 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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4-Fluoro-N-methyl-N-(1,2,3,4-tetrahydrocarbazol-3-yl)benzenesulfonamide
Rasmussen, K. G., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, p. o742Research output: Contribution to journal › Journal article › Research › peer-review
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6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists
Ulven, Trond, Little, P. B., Receveur, J., Frimurer, Thomas Michael, Rist, Ø., Nørregaard, P. K., Mathiesen, Jesper M. & Högberg, T., 2006, In: Bioorganic & Medicinal Chemistry Letters. 16, 4, p. 1070-1075 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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6-Acylamino-2-aminoquinolines as Potent Melanin-Concentrating Hormone 1 Receptor Antagonists
Ulven, Trond, Frimurer, Thomas Michael, Receveur, J., Little, P. B., Rist, Ø., Nørregaard, P. K. & Högberg, T., 2005, In: Journal of Medicinal Chemistry. 48, 18, p. 5684-5697 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor
Grundmann, M., Tikhonova, I. G., Hudson, B. D., Smith, N. J., Mohr, K., Ulven, Trond, Milligan, G., Kenakin, T. & Kostenis, E., 17 Mar 2016, In: Cell Chemical Biology. 23, 3, p. 392-403 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists
Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 19 Feb 2010, In: Journal of Organic Chemistry. 75, 4, p. 1301-1304 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer
Blättermann, S., Peters, L., Ottersbach, P. A., Bock, A., Konya, V., Weaver, C. D., Gonzalez, A., Schröder, R., Tyagi, R., Luschnig, P., Gäb, J., Hennen, S., Ulven, Trond, Pardo, L., Mohr, K., Gütschow, M., Heinemann, A. & Kostenis, E., 2012, In: Nature Chemical Biology. 8, 7, p. 631-638 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A concise synthesis of the potent inflammatory mediator 5-oxo-ETE
Tyagi, R., Shimpukade, B., Blättermann, S., Kostenis, E. & Ulven, Trond, 2012, In: MedChemComm. 3, p. 195-198 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A method for the selective hydrolysis of ketone hydrazones in the presence of acetals
Ulven, Trond & Carlsen, P. H. J., 2000, In: European Journal of Organic Chemistry. 2000, 21, p. 3971-3972 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands
Petersen, T. P., Ritzén, A. & Ulven, Trond, 19 Nov 2009, In: Organic Letters. 11, 22, p. 5134-5137 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst
Royer, J. F., Schratl, P., Lorenz, S., Kostenis, E., Ulven, Trond, Schuligoi, R., Peskar, B. A. & Heinemann, A., 1 Dec 2007, In: Allergy. 62, 12, p. 1401-1409 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A physicogenetic method to assign ligand-binding relationships between 7TM receptors
Frimurer, Thomas Michael, Ulven, Trond, Elling, T. C. E., Gerlach, L. O., Kostenis, E. & Högberg, T., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 16, p. 3707-3712 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
A protocol for amide bond formation with electron deficient amines and sterically hindered substrates
Due-Hansen, M. E., Pandey, S. K., Ulven, Elisabeth Rexen, Andersen, R., Hansen, S. V. F. & Ulven, Trond, 2016, In: Organic & Biomolecular Chemistry. 14, 2, p. 430-433 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A pseudo-sequence method for comparing 7TM receptors with respect to the physicochemical properties of their binding sites
Frimurer, Thomas Michael, Ulven, Trond, Högberg, T. & Elling, C. E., 2004, Patent No. WO 2004/079625Research output: Patent
A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias
Sergeev, E., Hansen, A. H., Bolognini, D., Kawakami, K., Kishi, T., Aoki, J., Ulven, Trond, Inoue, A., Hudson, B. D. & Milligan, G., 2017, In: Scientific Reports. 7, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Activation of GPR40 induces hypothalamic neurogenesis through p38-and BDNF-dependent mechanisms
Engel, D. F., Bobbo, V. C. D., Solon, C. S., Nogueira, G. A., Moura-Assis, A., Mendes, N. F., Zanesco, A. M., Papangelis, A., Ulven, Trond & Velloso, L. A., 2020, In: Scientific Reports. 10, 1, 12 p., 11047.Research output: Contribution to journal › Journal article › Research › peer-review
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Acute effects of delayed-release hydrolyzed pine nut oil on glucose tolerance, incretins, ghrelin and appetite in healthy humans
Sørensen, K. V., Korfitzen, S. S., Kaspersen, M. H., Ulven, Elisabeth Rexen, Ekberg, J. H., Bauer-Brandl, A., Ulven, Trond & Højlund, K., 2021, In: Clinical Nutrition. 40, 4, p. 2169-2179Research output: Contribution to journal › Journal article › Research › peer-review
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An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights
Köse, M., Pillaiyar, T., Namasivayam, V., De Filippo, E., Sylvester, K., Ulven, Trond, Von Kügelgen, I. & Müller, C. E., 12 Mar 2020, In: Journal of Medicinal Chemistry. 63, 5, p. 2391-2410 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
Uller, L., Mathiesen, Jesper M., Alenmyr, L., Korsgren, M., Ulven, Trond, Högberg, T., Andersson, G., Persson, C. G. A. & Kostenis, E., 1 Feb 2007, In: Respiratory Research. 8, 16Research output: Contribution to journal › Journal article › Research › peer-review
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Antidiabetic enolic glucoside of phenylpyruvic acid.
Joubert, E., Fey, S. J., Louw, J., Ulven, Trond & Tyagi, R., 12 Apr 2012, Patent No. WO 2012/045363A1Research output: Patent
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Autocrine negative feed-back regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT
Husted, Anna Sofie, Ekberg, J. H., Tripp, E., Nissen, T. A. D., Meijnikman, S., O'Brien, S. L., Ulven, Trond, Acherman, Y., Bruin, S. C., Nieuwdorp, M., Gerhart-Hines, Zach, Calebiro, D., Dragsted, Lars Ove & Schwartz, Thue W., 2020, In: Molecular Metabolism. 42, 10 p., 101103.Research output: Contribution to journal › Journal article › Research › peer-review
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Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival
Theiler, A., Bärnthaler, T., Platzer, W., Richtig, G., Peinhaupt, M., Rittchen, S., Kargl, J., Ulven, Trond, Marsh, L. M., Marsche, G., Schuligoi, R., Sturm, E. M. & Heinemann, A., 2019, In: The Journal of allergy and clinical immunology. 144, 3, p. 764-776Research output: Contribution to journal › Journal article › Research › peer-review
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CRTH2 receptor ligands for therapeutic use
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/115382 A1Research output: Patent
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CRTH2 receptor ligands for therapeutic use - B-series
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E. & Högberg, T., 2005, Patent No. WO 2005/115374 A1Research output: Patent
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Characterising pharmacological ligands to study the long chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4
Milligan, G., Alvarez-Curto, E., Watterson, K. R., Ulven, Trond & Hudson, B. D., 2015, In: British Journal of Pharmacology. 172, 13, p. 3254-3265 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues
Nicolaou, K. C., Namoto, K., Ritzén, A., Ulven, Trond, Shoji, M., Li, J., D'Amico, G., Liotta, D., French, C. T., Wartmann, M., Altmann, K. H. & Giannakakou, P., 26 Sep 2001, In: American Chemical Society. Journal. 123, 38, p. 9313-9323 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs
Hudson, B. D., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, Trond & Milligan, G., 2012, In: F A S E B Journal. 26, 12, p. 4951-4965 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemogenetics defines a short-chain fatty acid receptor gut-brain axis
Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, Trond, Hudson, B. D., Ulven, Elisabeth Rexen, Dekker, N., Tobin, A. B. & Milligan, G., 2022, In: eLife. 11, 23 p., e73777.Research output: Contribution to journal › Journal article › Research › peer-review
Complex Pharmacology of Free Fatty Acid Receptors
Milligan, G., Shimpukade, B., Ulven, Trond & Hudson, B. D., 11 Jan 2017, In: Chemical Reviews. 117, 1, p. 67-110 44 p.Research output: Contribution to journal › Journal article › Research › peer-review
Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands
Hudson, B. D., Ulven, Elisabeth Rexen, Murdoch, H., Jenkins, L., Hansen, A. H., Madsen, O., Ulven, Trond & Milligan, G., Aug 2014, In: Molecular Pharmacology. 86, 2, p. 200-210 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Compounds for the treatment of metabolic diseases
Ulven, Trond & Christiansen, E., 4 Feb 2010, Patent No. WO 2010/012650Research output: Patent
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Comprehensive and quantitative profiling of lipid species in human milk, cow milk and a phospholipid-enriched milk formula by GC and MS/MSALL
Sokol, O., Ulven, Trond, Færgeman, N. J. & Ejsing, C. S., 2015, In: European Journal of Lipid Science and Technology. 117, 6, p. 751-759 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4
Butcher, A. J., Hudson, B. D., Shimpukade, B., Alvarez-Curto, E., Prihandoko, R., Ulven, Trond, Milligan, G. & Tobin, A. B., 27 Jun 2014, In: Journal of Biological Chemistry. 289, 26, p. 18451-18465 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40
Schmidt, J., Liebscher, K., Merten, N., Grundmann, M., Mielenz, M., Sauerwein, H., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Ulven, Trond, Ullrich, S., Gomeza, J., Drewke, C. & Kostenis, E., 2011, In: Journal of Biological Chemistry. 286, 14, p. 11890-11894 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF
Petersen, T. P., Larsen, A. F., Ritzén, A. & Ulven, Trond, 2013, In: Journal of Organic Chemistry. 78, 8, p. 4190-4195 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Controlled generation and use of CO in flow
Hansen, S. V. F., Wilson, Z. E., Ulven, Trond & Ley, S. V., 2016, In: Reaction Chemistry & Engineering. 1, 3, p. 280-287 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cyclic Quinoline compounds for use in MCH receptor related disorders
Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052371Research output: Patent
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Cyclopropyl and cyclobutyl epothilone analogs
Nicolaou, K. C., Namoto, K., Ritzén, A., Ulven, Trond, Shoji, M. & Altmann, K., 2009, Patent No. EP 1,420,780 B1Research output: Patent
Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor
Hudson, B. D., Due-Hansen, M. E., Ulven, Elisabeth Rexen, Hansen, A., Mackenzie, A. E., Murdoch, H., Pandey, S. K., Ward, R. J., Marquez, R., Tikhonova, I. G., Ulven, Trond & Milligan, G., 14 Jun 2013, In: Journal of Biological Chemistry. 288, p. 17296-17312 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Design, synthesis and evaluation of 4,7-diamino-1,10-phenanthroline G-quadruplex ligands
Nielsen, M. C., Borch, J. & Ulven, Trond, 15 Dec 2009, In: Bioorganic & Medicinal Chemistry. 17, 24, p. 8241-8246 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)
Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2017, In: Journal of Medicinal Chemistry. 60, 13, p. 5638-5645 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer
Ulven, Elisabeth Rexen, Hudson, B. D., Hansen, A. H., Milligan, G. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 10, p. 4849-4858 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120
Ulven, Trond & Ulven, Elisabeth Rexen, 17 Jul 2015, In: Annual Review of Nutrition. 35, p. 239-263 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum
Domljanovic, I., Ulven, Elisabeth Rexen, Ulven, Trond, Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K., 31 Jul 2018, In: ACS Omega. 3, 7, p. 7580-7586 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Direct N9-arylation of purines with aryl halides
Larsen, A. F. & Ulven, Trond, 21 May 2014, In: Chemical Communications. 50, 39, p. 4997-4999 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery and structure-activity relationship investigations of 4-arylethynyldihydrocinnamic acid agonists of the antidiabetic target free fatty acid receptor 1
Christiansen, E., Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 2009.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Discovery of GPR183 Agonists Based on an Antagonist Scaffold
Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists
Valentini, Alice, Schultz-Knudsen, Katrine, Hansen, A. H., Tsakoumagkou, A., Jenkins, L., Christensen, H. B., Manandhar, Asmita, Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2023, In: Journal of Medicinal Chemistry. 66, 9, p. 6105–6121Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of TUG-770
Ulven, Elisabeth Rexen, Hansen, S. V. F., Urban, C., Hudson, B. D., Wargent, E. T., Grundmann, M., Jenkins, L., Zaibi, M., Stocker, C. J., Ullrich, S., Kostenis, E., Kassack, M. U., Milligan, G., Cawthorne, M. A. & Ulven, Trond, 9 May 2013, In: A C S Medicinal Chemistry Letters. 4, 5, p. 441-445 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy
Hansen, S. V. F., Ulven, Elisabeth Rexen, Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G. & Ulven, Trond, 1 Mar 2016, In: Journal of Medicinal Chemistry. 59, 6, p. 2841-2846 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties
Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2018, In: Journal of Medicinal Chemistry. 61, 21, p. 9534-9550 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of a potent and selective GPR120 agonist
Shimpukade, B., Hudson, B. D., Hovgaard, C. K., Milligan, G. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 9, p. 4511-4515 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability
Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schmidt, J., Hansen, S. V. F., Hudson, B. D., Zaibi, M., Markussen, S. B., Hagesaether, E., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 982-992 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes
Ulven, Elisabeth Rexen, Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A. D., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 27 Nov 2008, In: Journal of Medicinal Chemistry. 51, 22, p. 7061-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120
Prihandoko, R., Alvarez-Curto, E., Hudson, B. D., Butcher, A. J., Ulven, Trond, Miller, A. M., Tobin, A. B. & Milligan, G., 2016, In: Molecular Pharmacology. 89, 5, p. 505-520 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Drug Repurposing in Crohn's Disease Using Danish Real-World Data
Shakibfar, Saeed, Allin, K. H., Jess, T., Barbieri, M. A., Battini, V., Simoncic, E., Kirchgesner, J., Ulven, Trond & Sessa, Maurizio, 2024, In: Pragmatic and observational research. 15, p. 17-29Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of delayed-release olive oil and hydrolyzed pine nut oil on glucose tolerance, incretin secretion and appetite in humans
Sørensen, K. V., Kaspersen, M. H., Ekberg, J. H., Bauer-Brandl, A., Ulven, Trond & Højlund, K., 2021, In: Nutrients. 13, 10, 13 p., 3407.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficient Synthesis of 4,7-Diamino Substituted 1,10-Phenanthroline-2,9-dicarboxamides
Larsen, A. F. & Ulven, Trond, 2011, In: Organic Letters. 13, 13, p. 3546-3548 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Emerging roles of DP and CRTH2 in allergic inflammation
Kostenis, E. & Ulven, Trond, 2006, In: Trends in Molecular Medicine. 12, 4, p. 148-158 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ethyl 2-(1,2,3,4-tetrahydrospiro[carbazole-3,2'- [1,3]dioxolan]-9-yl)acetate
Loffler, P., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, Section E, p. o685Research output: Contribution to journal › Journal article › Research › peer-review
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Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3
Hudson, B. D., Tikhonova, I. G., Pandey, S. K., Ulven, Trond & Milligan, G., 2012, In: Journal of Biological Chemistry. 287, 49, p. 41195-41209 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extracellular loop 2 of the free Fatty Acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator
Smith, N. J., Ward, R. J., Stoddart, L. A., Hudson, B. D., Kostenis, E., Ulven, Trond, Morris, J. C., Tränkle, C., Tikhonova, I. G., Adams, D. R. & Milligan, G., 2011, In: Molecular Pharmacology. 80, 1, p. 163-173 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extraction of G-quadruplex ligands from disulfide-based dynamic combinatorial libraries
Nielsen, Mads & Ulven, Trond, 2009, p. ORGN-345.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
FFA1/Gq - Gi interaction determines glucose-induced insulin secretion of neonatal beta cells
Gerst, F., Lorza-Gil, E., Kaiser, G., Ulven, Trond, Kostenis, E., Haring, H. -., Birkenfeld, A. L. & Ullrich, S., 2022, In: Diabetologia. 65, Suppl 1, p. S109-S109Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells
Lorza-Gil, E., Kaiser, G., Ulven, Elisabeth Rexen, Koenig, G. M., Gerst, F., Oquendo, M. B., Birkenfeld, A. L., Haering, H., Kostenis, E., Ulven, Trond & Ullrich, S., 2020, In: Scientific Reports. 10, 1, 11 p., 16497.Research output: Contribution to journal › Journal article › Research › peer-review
Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance
Houthuijzen, J. M., Oosterom, I., Hudson, B. D., Hirasawa, A., Daenen, L. G. M., McLean, C. M., Hansen, S. V. F., van Jaarsveld, M. T. M., Peeper, D. S., Jafari Sadatmand, S., Roodhart, J. M. L., van de Lest, C. H. A., Ulven, Trond, Ishihara, K., Milligan, G. & Voest, E., 2017, In: F A S E B Journal. 31, 5, p. 2195-2209 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Flow chemistry methods for the synthesis chemokine receptor ligands
Petersen, T. P., Ritzén, A. & Ulven, Trond, 2009, p. ORGN-570.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists
Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schröder, R., Hudson, B. D., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 14, p. 6624-6628 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional-Group-Tolerant Pd-Catalyzed Carbonylative Negishi Coupling with Aryl Iodides
Kalinin, D. V. & Ulven, Trond, 2023, In: Journal of Organic Chemistry. 88, 23, p. 16633-16638Research output: Contribution to journal › Journal article › Research › peer-review
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G protein-coupled receptor modulators and a pharmaceutical composition
Ulven, Trond & Ieremias, L., 2021, IPC No. A61K31/44, A61P25/00, A61P29/00, C07D213/69, C07D405/12, Patent No. WO 2021/123394 A1, 18 Dec 2020, Priority date 20 Dec 2019, Priority No. EP20150090AResearch output: Patent
G-protein-coupled receptors for free fatty acids
Milligan, G., Ulven, Trond, Murdoch, H. & Hudson, B. D., 2 Jan 2014, In: British Journal of Nutrition. 111, Supplement S1, p. S3-S7Research output: Contribution to journal › Journal article › Research › peer-review
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GPR120 receptor modulators
Ulven, Trond & Shimpukade, B., 26 Sep 2013, Patent No. WO 2013/139341 A1Research output: Patent
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GPR120 receptor modulators
Ulven, Trond & Shimpukade, B., 19 Dec 2013, Patent No. WO 2013/185766 A1Research output: Patent
- Published
Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets
Lorza-Gil, E., Kaiser, G., Carlein, C., Hoffmann, M. D. A., König, G. M., Haug, S., Prates Roma, L., Ulven, Elisabeth Rexen, Ulven, Trond, Kostenis, E., Birkenfeld, A. L., Häring, H. U., Ullrich, S. & Gerst, F., 2023, In: Diabetologia. 66, p. 1501–1515Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production
Sencio, V., Barthelemy, A., Tavares, L. P., Machado, M. G., Soulard, D., Cuinat, C., Queiroz-Junior, C. M., Noordine, M. L., Salomé-Desnoulez, S., Deryuter, L., Foligné, B., Wahl, C., Frisch, B., Vieira, A. T., Paget, C., Milligan, G., Ulven, T., Wolowczuk, I., Faveeuw, C., Le Goffic, R. & 4 others, , 3 Mar 2020, In: Cell Reports. 30, 9, p. 2934-2947.e6Research output: Contribution to journal › Journal article › Research › peer-review
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Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance
Dragano, N. R. V., Milbank, E., Haddad-Tóvolli, R., Garrido-Gil, P., Nóvoa, E., Fondevilla, M. F., Capelli, V., Zanesco, A. M., Solon, C., Morari, J., Pires, L., Estevez-Salguero, Á., Beiroa, D., González-García, I., Barca-Mayo, O., Diéguez, C., Nogueiras, R., Labandeira-García, J. L., Rexen Ulven, E., Ulven, T. & 3 others, , 2024, In: Molecular Metabolism. 79, 13 p., 101840.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library
Yao, R., Jensen, Anders A., Bryce-Rogers, H. P., Schultz-Knudsen, Katrine, Zhou, L., Hovendal, N. P., Pedersen, H., Kubus, M., Ulven, Trond & Laraia, L., 2023, In: Journal of Medicinal Chemistry. 66, 16, p. 11536-11554Research output: Contribution to journal › Journal article › Research › peer-review
Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties
Ulven, Elisabeth Rexen, Urban, C., Grundmann, M., Due-Hansen, M. E., Hagesaether, E., Schmidt, J., Pardo, L., Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2011, In: Journal of Medicinal Chemistry. 54, 19, p. 6691-6703 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of galectin-1 and other cellular targets of alpha,beta-unsaturated carbonyl compounds, including dimethylfumarate, by use of click-chemistry probes
Sauerland, Max Benjamin, Helm, C., Lorentzen, Lasse Gøbel, Manandhar, Asmita, Ulven, Trond, Gamon, Luke Francis & Davies, Michael J., 2023, In: Redox Biology. 59, 15 p., 102560.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2
Mathiesen, Jesper M., Ulven, Trond, Martin, L., Gerlach, L., Heinemann, A. & Kostenis, E., 2005, In: Molecular Pharmacology. 68, 2, p. 393-402 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469
Urban, C., Hamacher, A., Partke, H. J., Roden, M., Schinner, S., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Ulven, Trond, Gohlke, H. & Kassack, M. U., 17 Jul 2013, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 386, 12, p. 1021-2030 1010 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Macrocyclic G-quadruplex ligands
Nielsen, M. C. & Ulven, Trond, 1 Jan 2010, In: Current Medicinal Chemistry. 17, 29, p. 3438-3448 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Method of synthesizing a 5-oxo-conjugated fatty acid
Ulven, Trond & Tyagi, R., 27 Oct 2011, Patent No. WO 2011/131619 A1Research output: Patent
- Published
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization
Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.Research output: Contribution to journal › Journal article › Research › peer-review
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Minor Structural Modifications Convert the Dual TP/CRTH2 Antagonist Ramatroban into a Highly Selective and Potent CRTH2 Antagonist
Ulven, Trond & Kostenis, E., 2005, In: Journal of Medicinal Chemistry. 48, 4, p. 897-900 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors
Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)
Karlshøj, S., Amarandi, R. M., Larsen, Olav, Daugvilaite, V., Steen, A., Brvar, M., Pui, A., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 23 Dec 2016, In: Journal of Biological Chemistry. 291, 52, p. 26860-26874Research output: Contribution to journal › Journal article › Research › peer-review
Mucus can change the permeation rank order of drug candidates
Hagesaether, E., Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 2013, In: International Journal of Pharmaceutics. 452, 1-2, p. 276-282 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multistep Continuous-Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure-Activity Relationships of CCR8 Ligands
Petersen, T. P., Mirsharghi, S., Rummel, P. C., Thiele, S., Rosenkilde, Mette, Ritzén, A. & Ulven, Trond, 8 Jul 2013, In: Chemistry: A European Journal. 19, 28, p. 9343-50 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity
Goncalves de Azavedo, C. M. B. P., Watterson, K. R., Wargent, E. T., Hansen, S. V. F., Hudson, B. D., Kępczyńska, M. A., Dunlop, J., Shimpukade, B., Ulven, Elisabeth Rexen, Milligan, G., Stocker, C. J. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8868-8878 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands
Sergeev, E., Hojgaard Hansen, A., Pandey, S. K., Mackenzie, A. E., Hudson, B. D., Ulven, Trond & Milligan, G., 2016, In: Journal of Biological Chemistry. 291, p. 303-317 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel CRTH2 antagonists: a review of patents from 2006 to 2009
Ulven, Trond & Kostenis, E., 1 Nov 2010, In: Expert Opinion on Therapeutic Patents. 20, 11, p. 1505-1530 26 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice
Murtaza, B., Hichami, A., Khan, A. S., Shimpukade, B., Ulven, Trond, Ozdener, M. H. & Khan, N. A., 2020, In: Journal of Lipid Research. 61, 2, p. 133-142 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel benzamide compounds for use in MCH receptor related disorders
Högberg, T., Bjurling, A. E., Receveur, J., Ulven, Trond, Elling, C. E. & Nørregaard, P. K., 2004, Patent No. WO 2004/048319Research output: Patent
- Published
Novel chemistry of alpha-tosyloxy ketones: applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries
Nicolaou, K. C., Montagnon, T., Ulven, Trond, Baran, P. S., Zhong, Y. & Sarabia, F., 22 May 2002, In: American Chemical Society. Journal. 124, 20, p. 5718-5728 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits
Ulven, Trond, Receveur, J., Grimstrup, M., Rist, Ø., Frimurer, Thomas Michael, Gerlach, L., Mathiesen, Jesper M., Kostenis, E., Uller, L. & Högberg, T., 2006, In: Journal of Medicinal Chemistry. 49, 23, p. 6638-6641 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1
Rist, O., Grimstrup, M., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Kostenis, E. & Högberg, T., 4 Dec 2009, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1177-1180 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2
Grimstrup, M., Rist, Ø., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Mathiesen, Jesper M., Kostenis, E. & Högberg, T., 1 Feb 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1181-1185 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the mechanism of interaction of potent, surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2
Mathiesen, Jesper M., Christopoulos, A., Ulven, Trond, Royer, J. F., Campillo, M., Heinemann, A., Pardo, L. & Kostenis, E., 2006, In: Molecular Pharmacology. 69, 4, p. 1441-1453 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival
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Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum
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